Limits...
MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

Show MeSH

Related in: MedlinePlus

Flow chart of study selection.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3750000&req=5

pone-0073367-g001: Flow chart of study selection.

Mentions: After comprehensive searching of 71 articles, we identified 10 relevant publications including 6101 cases and 10521 controls from 13 studies to assess the association between MNS16A and cancer risk (Figure 1): 2 studies focused on glioblastoma [15], [16], 2 studies focused on glioma [15], [16], 3 studies focused on non-small cell lung cancer [14], [17], [18], 2 studies focused on breast cancer[19], [20] and each was one for meningioma [15], colorectal carcinoma [21], nasopharyngeal carcinoma [22] and prostate cancer [23] (Table 1). All studies were case-control studies, of which the most frequently investigated was brain cancer (6451 subjects; 38.81%). Among these, 9 studies were conducted in Caucasians (10400 subjects; 62.57%) and 4 in Asians (6222 subjects; 37.43%).


MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.

Xia X, Rui R, Quan S, Zhong R, Zou L, Lou J, Lu X, Ke J, Zhang T, Zhang Y, Liu L, Yan J, Miao X - PLoS ONE (2013)

Flow chart of study selection.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3750000&req=5

pone-0073367-g001: Flow chart of study selection.
Mentions: After comprehensive searching of 71 articles, we identified 10 relevant publications including 6101 cases and 10521 controls from 13 studies to assess the association between MNS16A and cancer risk (Figure 1): 2 studies focused on glioblastoma [15], [16], 2 studies focused on glioma [15], [16], 3 studies focused on non-small cell lung cancer [14], [17], [18], 2 studies focused on breast cancer[19], [20] and each was one for meningioma [15], colorectal carcinoma [21], nasopharyngeal carcinoma [22] and prostate cancer [23] (Table 1). All studies were case-control studies, of which the most frequently investigated was brain cancer (6451 subjects; 38.81%). Among these, 9 studies were conducted in Caucasians (10400 subjects; 62.57%) and 4 in Asians (6222 subjects; 37.43%).

Bottom Line: The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility.Additional larger studies were warranted to validate our findings.

View Article: PubMed Central - PubMed

Affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

ABSTRACT

Background: Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.

Methods: A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.

Results: 10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.

Conclusions: The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.

Show MeSH
Related in: MedlinePlus