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Effect of tomato consumption on high-density lipoprotein cholesterol level: a randomized, single-blinded, controlled clinical trial.

Cuevas-Ramos D, Almeda-Valdés P, Chávez-Manzanera E, Meza-Arana CE, Brito-Córdova G, Mehta R, Pérez-Méndez O, Gómez-Pérez FJ - Diabetes Metab Syndr Obes (2013)

Bottom Line: Epidemiologic evidence suggests that tomato-based products could reduce the risk of cardiovascular diseases.Twenty patients (40%) finished the study with levels >40 mg/dL.Raw tomato consumption produced a favorable effect on HDL-C levels in overweight women.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

ABSTRACT

Introduction: Epidemiologic evidence suggests that tomato-based products could reduce the risk of cardiovascular diseases. One of the main cardiovascular risk factors is low levels of high-density lipoprotein cholesterol (HDL-C). This study aimed to prospectively evaluate the effect of tomato consumption on HDL-C levels.

Subject and methods: We conducted a randomized, single-blinded, controlled clinical trial. We screened 432 subjects with a complete lipid profile. Those individuals with low HDL-C (men <40 mg/dL and women <50 mg/dL) but normal triglyceride levels (<150 mg/dL) were included. Selected participants completed a 2-week run-in period on an isocaloric diet and then were randomized to receive 300 g of cucumber (control group) or two uncooked Roma tomatoes a day for 4 weeks.

Results: A total of 50 individuals (women = 41; 82%) with a mean age of 42 ± 15.5 years and a mean body mass index of 27.6 ± 5.0 kg/m(2) completed the study. A significant increase in HDL-C levels was observed in the tomato group (from 36.5 ± 7.5 mg/dL to 41.6 ± 6.9 mg/dL, P < 0.0001 versus the control group). After stratification by gender, the difference in HDL-C levels was only significant in women. The mean HDL-C increase was 5.0 ± 2.8 mg/dL (range 1-12 mg/dL). Twenty patients (40%) finished the study with levels >40 mg/dL. A linear regression model that adjusted for those parameters that impact HDL-C levels (age, gender, waist-to-hip ratio, body mass index, fasting triglyceride concentration, simple sugars, alcohol, physical activity, and omega-3 consumption) showed an independent association between tomato consumption and the increase in HDL-C (r (2) = 0.69; P < 0.0001).

Conclusion: Raw tomato consumption produced a favorable effect on HDL-C levels in overweight women.

No MeSH data available.


Related in: MedlinePlus

Correlation between the change in HDL-C levels and the number of days reported with complete adherence to cucumber (control group) or tomato consumption.Note: Dotted lines represent a 95% confidence interval.Abbreviation: HDL-C, high-density lipoprotein cholesterol.
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f2-dmso-6-263: Correlation between the change in HDL-C levels and the number of days reported with complete adherence to cucumber (control group) or tomato consumption.Note: Dotted lines represent a 95% confidence interval.Abbreviation: HDL-C, high-density lipoprotein cholesterol.

Mentions: Baseline values of HDL-C (36.5 ± 7.5 mg/dL versus 36.8 ± 7.2 mg/dL, P = 0.83) and triglyceride levels (113.4 ± 46.4 mg/dL versus 108.5 ± 36.9 mg/dL, P = 0.54) were similar between groups. Additionally, at baseline, serum triglycerides (P = 0.77), total cholesterol (P = 0.82), and LDL-C (P = 0.37) were not different between groups (Table 2). After 1 month of intervention, a significant increment of HDL-C levels from 36.5 ± 7.5 mg/dL to 41.6 ± 6.96 mg/dL (P < 0.0001) was observed in the group assigned to tomato consumption (Table 2). The mean increment of HDL-C was 5.0 ± 2.8 mg/dL (range 1–12 mg/dL). Levels of triglycerides, LDL-C, and total cholesterol did not change significantly. Adherence correlated positively with the HDL-C increment in the tomato group (r = 0.34, P = 0.01). This association was not identified with cucumber consumption (r = 0.08, P = 0.71; Figure 2). Figure 3 shows the change in HDL-C levels according to days of adherence (Figure 3A) and in every case studied (Figure 3B).


Effect of tomato consumption on high-density lipoprotein cholesterol level: a randomized, single-blinded, controlled clinical trial.

Cuevas-Ramos D, Almeda-Valdés P, Chávez-Manzanera E, Meza-Arana CE, Brito-Córdova G, Mehta R, Pérez-Méndez O, Gómez-Pérez FJ - Diabetes Metab Syndr Obes (2013)

Correlation between the change in HDL-C levels and the number of days reported with complete adherence to cucumber (control group) or tomato consumption.Note: Dotted lines represent a 95% confidence interval.Abbreviation: HDL-C, high-density lipoprotein cholesterol.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3735277&req=5

f2-dmso-6-263: Correlation between the change in HDL-C levels and the number of days reported with complete adherence to cucumber (control group) or tomato consumption.Note: Dotted lines represent a 95% confidence interval.Abbreviation: HDL-C, high-density lipoprotein cholesterol.
Mentions: Baseline values of HDL-C (36.5 ± 7.5 mg/dL versus 36.8 ± 7.2 mg/dL, P = 0.83) and triglyceride levels (113.4 ± 46.4 mg/dL versus 108.5 ± 36.9 mg/dL, P = 0.54) were similar between groups. Additionally, at baseline, serum triglycerides (P = 0.77), total cholesterol (P = 0.82), and LDL-C (P = 0.37) were not different between groups (Table 2). After 1 month of intervention, a significant increment of HDL-C levels from 36.5 ± 7.5 mg/dL to 41.6 ± 6.96 mg/dL (P < 0.0001) was observed in the group assigned to tomato consumption (Table 2). The mean increment of HDL-C was 5.0 ± 2.8 mg/dL (range 1–12 mg/dL). Levels of triglycerides, LDL-C, and total cholesterol did not change significantly. Adherence correlated positively with the HDL-C increment in the tomato group (r = 0.34, P = 0.01). This association was not identified with cucumber consumption (r = 0.08, P = 0.71; Figure 2). Figure 3 shows the change in HDL-C levels according to days of adherence (Figure 3A) and in every case studied (Figure 3B).

Bottom Line: Epidemiologic evidence suggests that tomato-based products could reduce the risk of cardiovascular diseases.Twenty patients (40%) finished the study with levels >40 mg/dL.Raw tomato consumption produced a favorable effect on HDL-C levels in overweight women.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

ABSTRACT

Introduction: Epidemiologic evidence suggests that tomato-based products could reduce the risk of cardiovascular diseases. One of the main cardiovascular risk factors is low levels of high-density lipoprotein cholesterol (HDL-C). This study aimed to prospectively evaluate the effect of tomato consumption on HDL-C levels.

Subject and methods: We conducted a randomized, single-blinded, controlled clinical trial. We screened 432 subjects with a complete lipid profile. Those individuals with low HDL-C (men <40 mg/dL and women <50 mg/dL) but normal triglyceride levels (<150 mg/dL) were included. Selected participants completed a 2-week run-in period on an isocaloric diet and then were randomized to receive 300 g of cucumber (control group) or two uncooked Roma tomatoes a day for 4 weeks.

Results: A total of 50 individuals (women = 41; 82%) with a mean age of 42 ± 15.5 years and a mean body mass index of 27.6 ± 5.0 kg/m(2) completed the study. A significant increase in HDL-C levels was observed in the tomato group (from 36.5 ± 7.5 mg/dL to 41.6 ± 6.9 mg/dL, P < 0.0001 versus the control group). After stratification by gender, the difference in HDL-C levels was only significant in women. The mean HDL-C increase was 5.0 ± 2.8 mg/dL (range 1-12 mg/dL). Twenty patients (40%) finished the study with levels >40 mg/dL. A linear regression model that adjusted for those parameters that impact HDL-C levels (age, gender, waist-to-hip ratio, body mass index, fasting triglyceride concentration, simple sugars, alcohol, physical activity, and omega-3 consumption) showed an independent association between tomato consumption and the increase in HDL-C (r (2) = 0.69; P < 0.0001).

Conclusion: Raw tomato consumption produced a favorable effect on HDL-C levels in overweight women.

No MeSH data available.


Related in: MedlinePlus