Limits...
Cortical florbetapir-PET amyloid load in prodromal Alzheimer's disease patients.

Saint-Aubert L, Barbeau EJ, Péran P, Nemmi F, Vervueren C, Mirabel H, Payoux P, Hitzel A, Bonneville F, Gramada R, Tafani M, Vincent C, Puel M, Dechaumont S, Chollet F, Pariente J - EJNMMI Res (2013)

Bottom Line: AV-45 uptake was compared between groups in the precuneus, posterior cingulate, anterior cingulate, and orbito-frontal regions.Twenty-two patients and 17 matched control subjects were included in the study.We report a significant increase of cortical AV-45 uptake in the patients compared to the control subjects in all regions of interest.

View Article: PubMed Central - HTML - PubMed

Affiliation: INSERM, Imagerie Cérébrale et Handicaps Neurologiques UMR 825, Centre Hospitalier Universitaire de Toulouse, Place Dr Baylac, Pavillon Baudot, Toulouse CEDEX 9 31059, France. laure.saint-aubert@inserm.fr.

ABSTRACT

Background: Florbetapir (AV-45) has been shown to be a reliable tool to assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 has the ability to bind amyloid in the early stages of AD. In this study, we investigated AV-45 binding and its relation with cognitive performance in a group of patients at the prodromal stage of Alzheimer's disease, recruited according to strict inclusion criteria.

Methods: We recruited patients at the prodromal stage of AD and matched control subjects. AV-45 binding was assessed using an innovative extraction method allowing quantifying uptake in the cortex only. AV-45 uptake was compared between groups in the precuneus, posterior cingulate, anterior cingulate, and orbito-frontal regions. Correlations between AV-45 uptake and cognitive performance were assessed.

Results: Twenty-two patients and 17 matched control subjects were included in the study. We report a significant increase of cortical AV-45 uptake in the patients compared to the control subjects in all regions of interest. Specific correlations were found within the patient group between mean global amyloid cortical load and cognitive performance in three different memory tests.

Conclusions: These findings suggest that at the prodromal stage of AD, memory decline is linked to an increase of cortical β-amyloid load.

No MeSH data available.


Related in: MedlinePlus

Correlation between mean global cortical AV-45 standardized uptake value ratio (SUVr) and memory performance. At (A) the delayed free recall of the FCSRT (max = 16), (B) the delayed total recall of the FCSRT (max = 16), and (C) the naming subtest of the TOP 12 semantic test (max = 12).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3733998&req=5

Figure 2: Correlation between mean global cortical AV-45 standardized uptake value ratio (SUVr) and memory performance. At (A) the delayed free recall of the FCSRT (max = 16), (B) the delayed total recall of the FCSRT (max = 16), and (C) the naming subtest of the TOP 12 semantic test (max = 12).

Mentions: Performance on the delayed free recall (r = -.504, p = .017) and delayed total recall (r = -.553, p = .008) subtests of the FCSRT as well as the naming score at the TOP 12 semantic test (r = -.616, p = .002) correlated negatively with global SUVr (Figure 2). Of note, AV-45 uptake did not correlate with age, and no correlations were found between AV-45 uptake and CSF concentrations in the patient group.


Cortical florbetapir-PET amyloid load in prodromal Alzheimer's disease patients.

Saint-Aubert L, Barbeau EJ, Péran P, Nemmi F, Vervueren C, Mirabel H, Payoux P, Hitzel A, Bonneville F, Gramada R, Tafani M, Vincent C, Puel M, Dechaumont S, Chollet F, Pariente J - EJNMMI Res (2013)

Correlation between mean global cortical AV-45 standardized uptake value ratio (SUVr) and memory performance. At (A) the delayed free recall of the FCSRT (max = 16), (B) the delayed total recall of the FCSRT (max = 16), and (C) the naming subtest of the TOP 12 semantic test (max = 12).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3733998&req=5

Figure 2: Correlation between mean global cortical AV-45 standardized uptake value ratio (SUVr) and memory performance. At (A) the delayed free recall of the FCSRT (max = 16), (B) the delayed total recall of the FCSRT (max = 16), and (C) the naming subtest of the TOP 12 semantic test (max = 12).
Mentions: Performance on the delayed free recall (r = -.504, p = .017) and delayed total recall (r = -.553, p = .008) subtests of the FCSRT as well as the naming score at the TOP 12 semantic test (r = -.616, p = .002) correlated negatively with global SUVr (Figure 2). Of note, AV-45 uptake did not correlate with age, and no correlations were found between AV-45 uptake and CSF concentrations in the patient group.

Bottom Line: AV-45 uptake was compared between groups in the precuneus, posterior cingulate, anterior cingulate, and orbito-frontal regions.Twenty-two patients and 17 matched control subjects were included in the study.We report a significant increase of cortical AV-45 uptake in the patients compared to the control subjects in all regions of interest.

View Article: PubMed Central - HTML - PubMed

Affiliation: INSERM, Imagerie Cérébrale et Handicaps Neurologiques UMR 825, Centre Hospitalier Universitaire de Toulouse, Place Dr Baylac, Pavillon Baudot, Toulouse CEDEX 9 31059, France. laure.saint-aubert@inserm.fr.

ABSTRACT

Background: Florbetapir (AV-45) has been shown to be a reliable tool to assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 has the ability to bind amyloid in the early stages of AD. In this study, we investigated AV-45 binding and its relation with cognitive performance in a group of patients at the prodromal stage of Alzheimer's disease, recruited according to strict inclusion criteria.

Methods: We recruited patients at the prodromal stage of AD and matched control subjects. AV-45 binding was assessed using an innovative extraction method allowing quantifying uptake in the cortex only. AV-45 uptake was compared between groups in the precuneus, posterior cingulate, anterior cingulate, and orbito-frontal regions. Correlations between AV-45 uptake and cognitive performance were assessed.

Results: Twenty-two patients and 17 matched control subjects were included in the study. We report a significant increase of cortical AV-45 uptake in the patients compared to the control subjects in all regions of interest. Specific correlations were found within the patient group between mean global amyloid cortical load and cognitive performance in three different memory tests.

Conclusions: These findings suggest that at the prodromal stage of AD, memory decline is linked to an increase of cortical β-amyloid load.

No MeSH data available.


Related in: MedlinePlus