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A decision analytic approach to exposure-based chemical prioritization.

Mitchell J, Pabon N, Collier ZA, Egeghy PP, Cohen-Hubal E, Linkov I, Vallero DA - PLoS ONE (2013)

Bottom Line: These criteria are assessed and integrated within a decision analytic framework, facilitating rapid assessment and prioritization for future targeted testing and systems modeling.A case study outlines the prioritization process using 51 chemicals.The strength of this approach is the ability to integrate relevant statistical and mechanistic data with expert judgment, allowing for an initial tier assessment that can further inform targeted testing and risk management strategies.

View Article: PubMed Central - PubMed

Affiliation: Biosystems & Agricultural Engineering, Michigan State University, East Lansing, Michigan, United States of America.

ABSTRACT
The manufacture of novel synthetic chemicals has increased in volume and variety, but often the environmental and health risks are not fully understood in terms of toxicity and, in particular, exposure. While efforts to assess risks have generally been effective when sufficient data are available, the hazard and exposure data necessary to assess risks adequately are unavailable for the vast majority of chemicals in commerce. The US Environmental Protection Agency has initiated the ExpoCast Program to develop tools for rapid chemical evaluation based on potential for exposure. In this context, a model is presented in which chemicals are evaluated based on inherent chemical properties and behaviorally-based usage characteristics over the chemical's life cycle. These criteria are assessed and integrated within a decision analytic framework, facilitating rapid assessment and prioritization for future targeted testing and systems modeling. A case study outlines the prioritization process using 51 chemicals. The results show a preliminary relative ranking of chemicals based on exposure potential. The strength of this approach is the ability to integrate relevant statistical and mechanistic data with expert judgment, allowing for an initial tier assessment that can further inform targeted testing and risk management strategies.

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Related in: MedlinePlus

Example Chemical Exposure Potential Risk Matrix.
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pone-0070911-g002: Example Chemical Exposure Potential Risk Matrix.

Mentions: In addition to this quantitative integration, chemical property and life cycle scores can be visualized using a risk-reporting matrix (Figure 2) for a more qualitative assessment of aggregate chemical exposure potential.


A decision analytic approach to exposure-based chemical prioritization.

Mitchell J, Pabon N, Collier ZA, Egeghy PP, Cohen-Hubal E, Linkov I, Vallero DA - PLoS ONE (2013)

Example Chemical Exposure Potential Risk Matrix.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3733911&req=5

pone-0070911-g002: Example Chemical Exposure Potential Risk Matrix.
Mentions: In addition to this quantitative integration, chemical property and life cycle scores can be visualized using a risk-reporting matrix (Figure 2) for a more qualitative assessment of aggregate chemical exposure potential.

Bottom Line: These criteria are assessed and integrated within a decision analytic framework, facilitating rapid assessment and prioritization for future targeted testing and systems modeling.A case study outlines the prioritization process using 51 chemicals.The strength of this approach is the ability to integrate relevant statistical and mechanistic data with expert judgment, allowing for an initial tier assessment that can further inform targeted testing and risk management strategies.

View Article: PubMed Central - PubMed

Affiliation: Biosystems & Agricultural Engineering, Michigan State University, East Lansing, Michigan, United States of America.

ABSTRACT
The manufacture of novel synthetic chemicals has increased in volume and variety, but often the environmental and health risks are not fully understood in terms of toxicity and, in particular, exposure. While efforts to assess risks have generally been effective when sufficient data are available, the hazard and exposure data necessary to assess risks adequately are unavailable for the vast majority of chemicals in commerce. The US Environmental Protection Agency has initiated the ExpoCast Program to develop tools for rapid chemical evaluation based on potential for exposure. In this context, a model is presented in which chemicals are evaluated based on inherent chemical properties and behaviorally-based usage characteristics over the chemical's life cycle. These criteria are assessed and integrated within a decision analytic framework, facilitating rapid assessment and prioritization for future targeted testing and systems modeling. A case study outlines the prioritization process using 51 chemicals. The results show a preliminary relative ranking of chemicals based on exposure potential. The strength of this approach is the ability to integrate relevant statistical and mechanistic data with expert judgment, allowing for an initial tier assessment that can further inform targeted testing and risk management strategies.

Show MeSH
Related in: MedlinePlus