Limits...
Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats.

Gao X, Zeng Y, Liu S, Wang S - Lipids Health Dis (2013)

Bottom Line: The theory of Chinese medicine believes rage harms normal liver function, namely 'raged impairing liver' in short.Acute stressed rat's liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats.Acute stress had a direct influence on rat's liver lipid metabolism.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

ABSTRACT

Background: The theory of Chinese medicine believes rage harms normal liver function, namely 'raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats.

Methods and results: Comparison of liver function indicators, serum lipid level of rats under acute stress and normal rats, as well as detection of liver tissue in the SR - BI, ABCG5 and ABCG8 protein and gene expression changes. Acute stressed rats had shown a lower serum levels of albumin (P<0.01), HDL- cholesterol (P<0.01) than normal rats, with higher serum levels of globulin (P<0.01) and LDL-cholesterol (P<0.05). Acute stressed rat's liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats. Furthermore, liver gene expression of ABCG5 (P<0.01) and ABCG8 (P<0.05) were lower in acute stressed rats than in normal rats, while SR-BI was higher in acute stressed rats than in normal rats (P<0.01).

Conclusions: Acute stress had a direct influence on rat's liver lipid metabolism.

Show MeSH

Related in: MedlinePlus

Effects of a 14-day treat with tail clipping on 1% sucrose consumption. The results represent the mean ± SEM of values obtained from 8 rats in each group. The significance of differences from the normal group at ▲P<0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3733886&req=5

Figure 1: Effects of a 14-day treat with tail clipping on 1% sucrose consumption. The results represent the mean ± SEM of values obtained from 8 rats in each group. The significance of differences from the normal group at ▲P<0.05.

Mentions: Compared with the activity of sucrose consumption of normal group, 2.36 ± 0.15, the activity of sucrose consumption of model group, 2.06 ± 0.25, is much lower than compared with the activity of sucrose consumption the normal group, which states notable statistic difference (P<0.05) (Figure 1).


Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats.

Gao X, Zeng Y, Liu S, Wang S - Lipids Health Dis (2013)

Effects of a 14-day treat with tail clipping on 1% sucrose consumption. The results represent the mean ± SEM of values obtained from 8 rats in each group. The significance of differences from the normal group at ▲P<0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3733886&req=5

Figure 1: Effects of a 14-day treat with tail clipping on 1% sucrose consumption. The results represent the mean ± SEM of values obtained from 8 rats in each group. The significance of differences from the normal group at ▲P<0.05.
Mentions: Compared with the activity of sucrose consumption of normal group, 2.36 ± 0.15, the activity of sucrose consumption of model group, 2.06 ± 0.25, is much lower than compared with the activity of sucrose consumption the normal group, which states notable statistic difference (P<0.05) (Figure 1).

Bottom Line: The theory of Chinese medicine believes rage harms normal liver function, namely 'raged impairing liver' in short.Acute stressed rat's liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats.Acute stress had a direct influence on rat's liver lipid metabolism.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

ABSTRACT

Background: The theory of Chinese medicine believes rage harms normal liver function, namely 'raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats.

Methods and results: Comparison of liver function indicators, serum lipid level of rats under acute stress and normal rats, as well as detection of liver tissue in the SR - BI, ABCG5 and ABCG8 protein and gene expression changes. Acute stressed rats had shown a lower serum levels of albumin (P<0.01), HDL- cholesterol (P<0.01) than normal rats, with higher serum levels of globulin (P<0.01) and LDL-cholesterol (P<0.05). Acute stressed rat's liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats. Furthermore, liver gene expression of ABCG5 (P<0.01) and ABCG8 (P<0.05) were lower in acute stressed rats than in normal rats, while SR-BI was higher in acute stressed rats than in normal rats (P<0.01).

Conclusions: Acute stress had a direct influence on rat's liver lipid metabolism.

Show MeSH
Related in: MedlinePlus