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¹⁸F-FDG PET metabolic parameters and MRI perfusion and diffusion parameters in hepatocellular carcinoma: a preliminary study.

Ahn SJ, Park MS, Kim KA, Park JY, Kim I, Kang WJ, Lee SK, Kim MJ - PLoS ONE (2013)

Bottom Line: SUV(max) showed significant negative correlation with K(trans)(max) (ρ = -0.622, p = 0.002).However, variables of ADC showed no relationship with variables of K(trans) or SUV(max) (p>0.05).Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K(trans) (p>0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Yonsei Liver Cancer Special Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea.

ABSTRACT

Objectives: Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as ¹⁸F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).

Materials and methods: Twenty-one patients with advanced HCC underwent ¹⁸F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV(max)) from ¹⁸F-FDG-PET, variables of the volume transfer constant (K(trans)) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV(max) and variables of K(trans) and ADC was evaluated by Mann-Whitney test.

Results: SUV(max) showed significant negative correlation with K(trans)(max) (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K(trans) or SUV(max) (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K(trans) (p>0.05).

Conclusion: In this study, SUV was shown to be correlated with K(trans) in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.

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Related in: MedlinePlus

Advanced HCC in the Rt. lobe is well differentiated from normal liver parenchyma on delayed phase of DCE MRI(A), 7∼8 min after contrast injection.After ADC map (B) is coregistered to delayed phase of DCE MRI(A), ROI(red dotted line) was drawn along the tumor border on the coregistered image(C) and ADC value was calculated. Ktrans color coded map(D) is also achieved based on the delayed phase of DCE MRI.
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pone-0071571-g001: Advanced HCC in the Rt. lobe is well differentiated from normal liver parenchyma on delayed phase of DCE MRI(A), 7∼8 min after contrast injection.After ADC map (B) is coregistered to delayed phase of DCE MRI(A), ROI(red dotted line) was drawn along the tumor border on the coregistered image(C) and ADC value was calculated. Ktrans color coded map(D) is also achieved based on the delayed phase of DCE MRI.

Mentions: ADC maps were co-registered to the last phase on DCE MRI (7∼8 minutes after contrast injection) using commercial software (nordicICE, NordicNeuroLab), based on Digital Imaging and Communication in Medicine geometry parameters (Figure 1). Manual adjustment of image registration was performed if necessary. ROI for ADC was drawn along the tumor border on the same ROIs as co-registered Ktrans map. Maximum, minimum, median, and mean values of ADC (ADCmax, ADCmin, ADCmedian and ADCmean) for the covered tumor volume were calculated. Tumors were distinctly differentiated from the normal parenchyma on this co-registered image.


¹⁸F-FDG PET metabolic parameters and MRI perfusion and diffusion parameters in hepatocellular carcinoma: a preliminary study.

Ahn SJ, Park MS, Kim KA, Park JY, Kim I, Kang WJ, Lee SK, Kim MJ - PLoS ONE (2013)

Advanced HCC in the Rt. lobe is well differentiated from normal liver parenchyma on delayed phase of DCE MRI(A), 7∼8 min after contrast injection.After ADC map (B) is coregistered to delayed phase of DCE MRI(A), ROI(red dotted line) was drawn along the tumor border on the coregistered image(C) and ADC value was calculated. Ktrans color coded map(D) is also achieved based on the delayed phase of DCE MRI.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3733842&req=5

pone-0071571-g001: Advanced HCC in the Rt. lobe is well differentiated from normal liver parenchyma on delayed phase of DCE MRI(A), 7∼8 min after contrast injection.After ADC map (B) is coregistered to delayed phase of DCE MRI(A), ROI(red dotted line) was drawn along the tumor border on the coregistered image(C) and ADC value was calculated. Ktrans color coded map(D) is also achieved based on the delayed phase of DCE MRI.
Mentions: ADC maps were co-registered to the last phase on DCE MRI (7∼8 minutes after contrast injection) using commercial software (nordicICE, NordicNeuroLab), based on Digital Imaging and Communication in Medicine geometry parameters (Figure 1). Manual adjustment of image registration was performed if necessary. ROI for ADC was drawn along the tumor border on the same ROIs as co-registered Ktrans map. Maximum, minimum, median, and mean values of ADC (ADCmax, ADCmin, ADCmedian and ADCmean) for the covered tumor volume were calculated. Tumors were distinctly differentiated from the normal parenchyma on this co-registered image.

Bottom Line: SUV(max) showed significant negative correlation with K(trans)(max) (ρ = -0.622, p = 0.002).However, variables of ADC showed no relationship with variables of K(trans) or SUV(max) (p>0.05).Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K(trans) (p>0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Yonsei Liver Cancer Special Clinic, Yonsei University College of Medicine, Seoul, Republic of Korea.

ABSTRACT

Objectives: Glucose metabolism, perfusion, and water diffusion may have a relationship or affect each other in the same tumor. The understanding of their relationship could expand the knowledge of tumor characteristics and contribute to the field of oncologic imaging. The purpose of this study was to evaluate the relationships between metabolism, vasculature and cellularity of advanced hepatocellular carcinoma (HCC), using multimodality imaging such as ¹⁸F-FDG positron emission tomography (PET), dynamic contrast enhanced (DCE)-MRI, and diffusion weighted imaging(DWI).

Materials and methods: Twenty-one patients with advanced HCC underwent ¹⁸F-FDG PET, DCE-MRI, and DWI before treatment. Maximum standard uptake values (SUV(max)) from ¹⁸F-FDG-PET, variables of the volume transfer constant (K(trans)) from DCE-MRI and apparent diffusion coefficient (ADC) from DWI were obtained for the tumor and their relationships were examined by Spearman's correlation analysis. The influence of portal vein thrombosis on SUV(max) and variables of K(trans) and ADC was evaluated by Mann-Whitney test.

Results: SUV(max) showed significant negative correlation with K(trans)(max) (ρ = -0.622, p = 0.002). However, variables of ADC showed no relationship with variables of K(trans) or SUV(max) (p>0.05). Whether portal vein thrombosis was present or not did not influence the SUV max and variables of ADC and K(trans) (p>0.05).

Conclusion: In this study, SUV was shown to be correlated with K(trans) in advanced HCCs; the higher the glucose metabolism a tumor had, the lower the perfusion it had, which might help in guiding target therapy.

Show MeSH
Related in: MedlinePlus