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Prevention of contamination by biopsy needle track contamination using a novel adriamycin-loaded gelatin sponge.

Li ZF, Li JM, Yan J, Yang ZP, Li X, Yang Q - World J Surg Oncol (2013)

Bottom Line: Data were obtained from 40 patients who were diagnosed by core needle biopsy as having osteosarcoma and who were followed up at our hospital between 2008 and 2011.Of the 40 patients, 20 had the needle biopsy tracks filled with ADM-loaded absorbable gelatin sponge immediately after the biopsy specimen was obtained, while the other 20 did not.Use of ADM-loaded absorbable gelatin sponge may prevent tumor cell contamination of a biopsy track, and reduce the possibility of consequent tumor relapse.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, 107 Wenhuaxilu, Jinan, Shandong Province 250012, China.

ABSTRACT

Background: The gold standard of tumor diagnosis is histological examination of a biopsy; however, there is concern that tumor cell dissemination along the needle track during percutaneous biopsy can cause local tumor relapse. We aimed to evaluate the value of an adriamycin (ADM)-loaded gelatin sponge in preventing tumor cell contamination along the biopsy needle track.

Methods: Data were obtained from 40 patients who were diagnosed by core needle biopsy as having osteosarcoma and who were followed up at our hospital between 2008 and 2011. Of the 40 patients, 20 had the needle biopsy tracks filled with ADM-loaded absorbable gelatin sponge immediately after the biopsy specimen was obtained, while the other 20 did not. All 40 patients underwent limb-salvage surgery, and specimens were obtained from the biopsy track for histopathologic examination of multiple sections.

Results: On histological examination, there was less tumor cell contamination along the biopsy tracks in the ADM group.

Conclusion: Use of ADM-loaded absorbable gelatin sponge may prevent tumor cell contamination of a biopsy track, and reduce the possibility of consequent tumor relapse.

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Fat and tumor cells in the pathology examination.
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Figure 5: Fat and tumor cells in the pathology examination.

Mentions: No tumor seeding was found along the needle tracks based on the pathologic results for the ADM group. In the control group, tumor cells were found along the needle tracks in three cases (FiguresĀ 3, 4 and 5). Using the small sample t-test a significant difference (P < 0.05) was found between the ADM and non-ADM groups.


Prevention of contamination by biopsy needle track contamination using a novel adriamycin-loaded gelatin sponge.

Li ZF, Li JM, Yan J, Yang ZP, Li X, Yang Q - World J Surg Oncol (2013)

Fat and tumor cells in the pathology examination.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3733771&req=5

Figure 5: Fat and tumor cells in the pathology examination.
Mentions: No tumor seeding was found along the needle tracks based on the pathologic results for the ADM group. In the control group, tumor cells were found along the needle tracks in three cases (FiguresĀ 3, 4 and 5). Using the small sample t-test a significant difference (P < 0.05) was found between the ADM and non-ADM groups.

Bottom Line: Data were obtained from 40 patients who were diagnosed by core needle biopsy as having osteosarcoma and who were followed up at our hospital between 2008 and 2011.Of the 40 patients, 20 had the needle biopsy tracks filled with ADM-loaded absorbable gelatin sponge immediately after the biopsy specimen was obtained, while the other 20 did not.Use of ADM-loaded absorbable gelatin sponge may prevent tumor cell contamination of a biopsy track, and reduce the possibility of consequent tumor relapse.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Orthopaedics, Qilu Hospital of Shandong University, 107 Wenhuaxilu, Jinan, Shandong Province 250012, China.

ABSTRACT

Background: The gold standard of tumor diagnosis is histological examination of a biopsy; however, there is concern that tumor cell dissemination along the needle track during percutaneous biopsy can cause local tumor relapse. We aimed to evaluate the value of an adriamycin (ADM)-loaded gelatin sponge in preventing tumor cell contamination along the biopsy needle track.

Methods: Data were obtained from 40 patients who were diagnosed by core needle biopsy as having osteosarcoma and who were followed up at our hospital between 2008 and 2011. Of the 40 patients, 20 had the needle biopsy tracks filled with ADM-loaded absorbable gelatin sponge immediately after the biopsy specimen was obtained, while the other 20 did not. All 40 patients underwent limb-salvage surgery, and specimens were obtained from the biopsy track for histopathologic examination of multiple sections.

Results: On histological examination, there was less tumor cell contamination along the biopsy tracks in the ADM group.

Conclusion: Use of ADM-loaded absorbable gelatin sponge may prevent tumor cell contamination of a biopsy track, and reduce the possibility of consequent tumor relapse.

Show MeSH
Related in: MedlinePlus