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Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism.

Berk S, Dogan OT, Aydemir EI, Bingol A, Ozsahin SL, Akkurt I - Multidiscip Respir Med (2013)

Bottom Line: It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker.Multi-slice computed tomographic angiography was used to verify the diagnosis of PE.PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chest Diseases, Medical Faculty of Cumhuriyet University, Sivas, Turkey. serdar.berk@yahoo.com.

ABSTRACT

Background: The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE.

Methods: 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE.

Results: PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively).

Conclusions: Serum PAPP-A level has no role in the evaluation for PE.

No MeSH data available.


Related in: MedlinePlus

Sixty eight-year-old female patient with pulmonary emboli.
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Figure 1: Sixty eight-year-old female patient with pulmonary emboli.

Mentions: On the thorax multi-slice CT angiography, PE was detected in 24 patients (PE+) (Figure 1), while it was excluded in 29 (PE-) of 53 patients. Out of the 29 patients without PE, 20were affected with pneumonia, 5 with COPD exacerbation, one with Dressler syndrome and onewith empyema, while restrictive pulmonary disorders causing acute respiratory stress was detected in two patients. Mean age was 62 ± 17 years in 24 patients with PE, and 63 ± 15 years in 29 patients without PE. 48% of the patients with PE were women, whereas 52% of those without PE were women. The mean age and sex distribution were similar in both groups (p > 0.05). While cough was more frequent in patients without PE, other clinical, radiological and laboratory finding were found to be similar in both groups (Tables 1 and 2). The distribution of serum PAPP-A values was similar in both groups (Figure 2). No significant difference was found in mean serum PAPP-A levels between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively; p = 0.399).


Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism.

Berk S, Dogan OT, Aydemir EI, Bingol A, Ozsahin SL, Akkurt I - Multidiscip Respir Med (2013)

Sixty eight-year-old female patient with pulmonary emboli.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3733691&req=5

Figure 1: Sixty eight-year-old female patient with pulmonary emboli.
Mentions: On the thorax multi-slice CT angiography, PE was detected in 24 patients (PE+) (Figure 1), while it was excluded in 29 (PE-) of 53 patients. Out of the 29 patients without PE, 20were affected with pneumonia, 5 with COPD exacerbation, one with Dressler syndrome and onewith empyema, while restrictive pulmonary disorders causing acute respiratory stress was detected in two patients. Mean age was 62 ± 17 years in 24 patients with PE, and 63 ± 15 years in 29 patients without PE. 48% of the patients with PE were women, whereas 52% of those without PE were women. The mean age and sex distribution were similar in both groups (p > 0.05). While cough was more frequent in patients without PE, other clinical, radiological and laboratory finding were found to be similar in both groups (Tables 1 and 2). The distribution of serum PAPP-A values was similar in both groups (Figure 2). No significant difference was found in mean serum PAPP-A levels between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively; p = 0.399).

Bottom Line: It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker.Multi-slice computed tomographic angiography was used to verify the diagnosis of PE.PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chest Diseases, Medical Faculty of Cumhuriyet University, Sivas, Turkey. serdar.berk@yahoo.com.

ABSTRACT

Background: The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE.

Methods: 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE.

Results: PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively).

Conclusions: Serum PAPP-A level has no role in the evaluation for PE.

No MeSH data available.


Related in: MedlinePlus