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Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism.

Berk S, Dogan OT, Aydemir EI, Bingol A, Ozsahin SL, Akkurt I - Multidiscip Respir Med (2013)

Bottom Line: PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan.No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively).Serum PAPP-A level has no role in the evaluation for PE.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chest Diseases, Medical Faculty of Cumhuriyet University, Sivas, Turkey. serdar.berk@yahoo.com.

ABSTRACT

Background: The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE.

Methods: 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE.

Results: PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively).

Conclusions: Serum PAPP-A level has no role in the evaluation for PE.

No MeSH data available.


Related in: MedlinePlus

Sixty eight-year-old female patient with pulmonary emboli.
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Figure 1: Sixty eight-year-old female patient with pulmonary emboli.

Mentions: On the thorax multi-slice CT angiography, PE was detected in 24 patients (PE+) (Figure 1), while it was excluded in 29 (PE-) of 53 patients. Out of the 29 patients without PE, 20were affected with pneumonia, 5 with COPD exacerbation, one with Dressler syndrome and onewith empyema, while restrictive pulmonary disorders causing acute respiratory stress was detected in two patients. Mean age was 62 ± 17 years in 24 patients with PE, and 63 ± 15 years in 29 patients without PE. 48% of the patients with PE were women, whereas 52% of those without PE were women. The mean age and sex distribution were similar in both groups (p > 0.05). While cough was more frequent in patients without PE, other clinical, radiological and laboratory finding were found to be similar in both groups (Tables 1 and 2). The distribution of serum PAPP-A values was similar in both groups (Figure 2). No significant difference was found in mean serum PAPP-A levels between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively; p = 0.399).


Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism.

Berk S, Dogan OT, Aydemir EI, Bingol A, Ozsahin SL, Akkurt I - Multidiscip Respir Med (2013)

Sixty eight-year-old female patient with pulmonary emboli.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3733691&req=5

Figure 1: Sixty eight-year-old female patient with pulmonary emboli.
Mentions: On the thorax multi-slice CT angiography, PE was detected in 24 patients (PE+) (Figure 1), while it was excluded in 29 (PE-) of 53 patients. Out of the 29 patients without PE, 20were affected with pneumonia, 5 with COPD exacerbation, one with Dressler syndrome and onewith empyema, while restrictive pulmonary disorders causing acute respiratory stress was detected in two patients. Mean age was 62 ± 17 years in 24 patients with PE, and 63 ± 15 years in 29 patients without PE. 48% of the patients with PE were women, whereas 52% of those without PE were women. The mean age and sex distribution were similar in both groups (p > 0.05). While cough was more frequent in patients without PE, other clinical, radiological and laboratory finding were found to be similar in both groups (Tables 1 and 2). The distribution of serum PAPP-A values was similar in both groups (Figure 2). No significant difference was found in mean serum PAPP-A levels between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively; p = 0.399).

Bottom Line: PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan.No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively).Serum PAPP-A level has no role in the evaluation for PE.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chest Diseases, Medical Faculty of Cumhuriyet University, Sivas, Turkey. serdar.berk@yahoo.com.

ABSTRACT

Background: The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE.

Methods: 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE.

Results: PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively).

Conclusions: Serum PAPP-A level has no role in the evaluation for PE.

No MeSH data available.


Related in: MedlinePlus