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Urinary 2,5-hexanedione excretion in cryptogenic polyneuropathy compared to the general Swedish population.

Persson B, Vrethem M, Murgia N, Lindh J, Hällsten AL, Fredrikson M, Tondel M - J Occup Med Toxicol (2013)

Bottom Line: Occupational exposure to xylene, alcohol consumption and ever exposed to general anaesthesia were associated with lower excretion in men while for occupational exposure to nitrous oxide in women higher excretion was seen.Higher excretion of 2,5 HD was inversely related to increasing age.The difference in means between cases and the general population is small and can therefore not allow any firm conclusions of the causality, however.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Neurology and Neurophysiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. magnus.vrethem@lio.se.

ABSTRACT

Background: 2,5-hexanedione (2,5-HD) is the main neurotoxic metabolite of methyl-n-butyl ketone (MBK) and n-hexane, and known to cause polyneuropathy. The aim of our study was to compare the urinary levels of 2,5-HD between cases with cryptogenic polyneuropathy and the general Swedish population, and to elucidate the role of certain external factors.

Methods: Morning urine samples were collected from 114 cases with cryptogenic polyneuropathy (77 men and 37 women) and 227 referents (110 men and 117 women) randomly selected from the population registry. None had any current occupational exposure to n-hexane or MBK. The urine samples were analysed by a gas chromatographic method based on acidic hydrolysis.

Results: Cases had statistically higher urinary levels of 2,5-HD (0.48 mg/L) than the general population (0.41 mg/L) and men higher excretion than women (0.48 mg/L and 0.38 mg/L, respectively). There was no difference in 2,5-HD levels between current smokers and non-smokers. Occupational exposure to xylene, alcohol consumption and ever exposed to general anaesthesia were associated with lower excretion in men while for occupational exposure to nitrous oxide in women higher excretion was seen. Higher excretion of 2,5 HD was inversely related to increasing age.

Conclusions: Significantly higher levels of urinary 2,5-HD were seen in men and cryptogenic polyneuropathy cases seemingly unexposed to n-hexane. Hypothetically, this might be due to either differences in metabolic patterns or some concealed exposure. The difference in means between cases and the general population is small and can therefore not allow any firm conclusions of the causality, however.

No MeSH data available.


Related in: MedlinePlus

Urinary levels of 2,5-hexanedione (2,5-HD) in mg/L, mean and 95% confidence interval, in cases and referents and men and women.
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Figure 1: Urinary levels of 2,5-hexanedione (2,5-HD) in mg/L, mean and 95% confidence interval, in cases and referents and men and women.

Mentions: Cases had statistically significant higher excretion of 2,5-HD in urine than referents (mean 0.48 mg/L compared to 0.41 mg/L) and men had statistically significant higher excretion than women (mean 0.48 mg/L compared to 0.38 mg/L) (Table 3, Figure 1). Excretion of 2,5-HD was higher in men compared to women within both cases and referents, however only statistically significant for the larger group of referents (Table 3). Also the urinary levels were higher for cases than for referents of both sexes although not statistically significant (Table 3). The excretion of 2,5-HD was inversely related to increasing age only for male referents (Figure 2). There was no statistically significant difference in urinary 2,5-HD levels between current smokers and non-smokers. No men reported occupational exposure to nitrous oxide.


Urinary 2,5-hexanedione excretion in cryptogenic polyneuropathy compared to the general Swedish population.

Persson B, Vrethem M, Murgia N, Lindh J, Hällsten AL, Fredrikson M, Tondel M - J Occup Med Toxicol (2013)

Urinary levels of 2,5-hexanedione (2,5-HD) in mg/L, mean and 95% confidence interval, in cases and referents and men and women.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3733657&req=5

Figure 1: Urinary levels of 2,5-hexanedione (2,5-HD) in mg/L, mean and 95% confidence interval, in cases and referents and men and women.
Mentions: Cases had statistically significant higher excretion of 2,5-HD in urine than referents (mean 0.48 mg/L compared to 0.41 mg/L) and men had statistically significant higher excretion than women (mean 0.48 mg/L compared to 0.38 mg/L) (Table 3, Figure 1). Excretion of 2,5-HD was higher in men compared to women within both cases and referents, however only statistically significant for the larger group of referents (Table 3). Also the urinary levels were higher for cases than for referents of both sexes although not statistically significant (Table 3). The excretion of 2,5-HD was inversely related to increasing age only for male referents (Figure 2). There was no statistically significant difference in urinary 2,5-HD levels between current smokers and non-smokers. No men reported occupational exposure to nitrous oxide.

Bottom Line: Occupational exposure to xylene, alcohol consumption and ever exposed to general anaesthesia were associated with lower excretion in men while for occupational exposure to nitrous oxide in women higher excretion was seen.Higher excretion of 2,5 HD was inversely related to increasing age.The difference in means between cases and the general population is small and can therefore not allow any firm conclusions of the causality, however.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Neurology and Neurophysiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. magnus.vrethem@lio.se.

ABSTRACT

Background: 2,5-hexanedione (2,5-HD) is the main neurotoxic metabolite of methyl-n-butyl ketone (MBK) and n-hexane, and known to cause polyneuropathy. The aim of our study was to compare the urinary levels of 2,5-HD between cases with cryptogenic polyneuropathy and the general Swedish population, and to elucidate the role of certain external factors.

Methods: Morning urine samples were collected from 114 cases with cryptogenic polyneuropathy (77 men and 37 women) and 227 referents (110 men and 117 women) randomly selected from the population registry. None had any current occupational exposure to n-hexane or MBK. The urine samples were analysed by a gas chromatographic method based on acidic hydrolysis.

Results: Cases had statistically higher urinary levels of 2,5-HD (0.48 mg/L) than the general population (0.41 mg/L) and men higher excretion than women (0.48 mg/L and 0.38 mg/L, respectively). There was no difference in 2,5-HD levels between current smokers and non-smokers. Occupational exposure to xylene, alcohol consumption and ever exposed to general anaesthesia were associated with lower excretion in men while for occupational exposure to nitrous oxide in women higher excretion was seen. Higher excretion of 2,5 HD was inversely related to increasing age.

Conclusions: Significantly higher levels of urinary 2,5-HD were seen in men and cryptogenic polyneuropathy cases seemingly unexposed to n-hexane. Hypothetically, this might be due to either differences in metabolic patterns or some concealed exposure. The difference in means between cases and the general population is small and can therefore not allow any firm conclusions of the causality, however.

No MeSH data available.


Related in: MedlinePlus