Limits...
The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials.

Li SH, Tian HB, Zhao HJ, Chen LH, Cui LQ - PLoS ONE (2013)

Bottom Line: The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls.Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion.The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, China.

ABSTRACT

Background: The acute effects of grape polyphenols on endothelial function in adults are inconsistent. Here, we performed meta-analyses to determine these acute effects as measured by flow-mediated dilation (FMD).

Methods: Trials were searched in PubMed, Embase and the Cochrane Library database. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the PROSPERO register and our registration number is CRD42013004157.

Results: Nine studies were included in the present meta-analyses. The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls. Meta-regression and subgroup analyses were performed and showed that a health status was the main effect modifier of the significant heterogeneity. Subgroups indicated that intake of grape polyphenols could significantly increase FMD in healthy subjects, and the increased FMD appeared to be more obviously in subjects with high cardiovascular risk factors. Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion.

Conclusions: Endothelial function can be significantly improved in healthy adults in the initial 2 h after intake of grape polyphenols. The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects.

Show MeSH

Related in: MedlinePlus

Meta-analysis of the 60 min effect of grape polyphenols on flow-mediated dilation (FMD) compared with controls.The sizes of the data markers indicate the weight of each study in the analysis. The subgroups were differentiated by health status of the subjects.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3722169&req=5

pone-0069818-g003: Meta-analysis of the 60 min effect of grape polyphenols on flow-mediated dilation (FMD) compared with controls.The sizes of the data markers indicate the weight of each study in the analysis. The subgroups were differentiated by health status of the subjects.

Mentions: Six studies [14]–[16], [18]–[20] reported the effects of grape polyphenols on FMD 60 min after intervention. The percentage change in FMD 60 min after the intervention was significantly higher in the grape polyphenols group than the control group (11 comparisons; WMD: 2.30%; 95% CI: 1.40, 3.20; P<0.00001) (Figure 3). Significant heterogeneity was found (heterogeneity I2 = 67%, P = 0.0007). Meta-regression indicated that health status might also be the main effect modifier (P<0.05). The dose of grape polyphenols, the intervention with alcohol or without alcohol, the baseline FMD level and the average age of the participants were not effect modifiers.


The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials.

Li SH, Tian HB, Zhao HJ, Chen LH, Cui LQ - PLoS ONE (2013)

Meta-analysis of the 60 min effect of grape polyphenols on flow-mediated dilation (FMD) compared with controls.The sizes of the data markers indicate the weight of each study in the analysis. The subgroups were differentiated by health status of the subjects.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3722169&req=5

pone-0069818-g003: Meta-analysis of the 60 min effect of grape polyphenols on flow-mediated dilation (FMD) compared with controls.The sizes of the data markers indicate the weight of each study in the analysis. The subgroups were differentiated by health status of the subjects.
Mentions: Six studies [14]–[16], [18]–[20] reported the effects of grape polyphenols on FMD 60 min after intervention. The percentage change in FMD 60 min after the intervention was significantly higher in the grape polyphenols group than the control group (11 comparisons; WMD: 2.30%; 95% CI: 1.40, 3.20; P<0.00001) (Figure 3). Significant heterogeneity was found (heterogeneity I2 = 67%, P = 0.0007). Meta-regression indicated that health status might also be the main effect modifier (P<0.05). The dose of grape polyphenols, the intervention with alcohol or without alcohol, the baseline FMD level and the average age of the participants were not effect modifiers.

Bottom Line: The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls.Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion.The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, China.

ABSTRACT

Background: The acute effects of grape polyphenols on endothelial function in adults are inconsistent. Here, we performed meta-analyses to determine these acute effects as measured by flow-mediated dilation (FMD).

Methods: Trials were searched in PubMed, Embase and the Cochrane Library database. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the PROSPERO register and our registration number is CRD42013004157.

Results: Nine studies were included in the present meta-analyses. The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls. Meta-regression and subgroup analyses were performed and showed that a health status was the main effect modifier of the significant heterogeneity. Subgroups indicated that intake of grape polyphenols could significantly increase FMD in healthy subjects, and the increased FMD appeared to be more obviously in subjects with high cardiovascular risk factors. Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion.

Conclusions: Endothelial function can be significantly improved in healthy adults in the initial 2 h after intake of grape polyphenols. The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects.

Show MeSH
Related in: MedlinePlus