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A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer.

Yu M, Lee JH, Jang HS, Jeon DM, Cheon JS, Lee HC, Lee JH - Radiat Oncol (2013)

Bottom Line: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs).Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiation Oncology, St, Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Ji-dong Paldal-gu, Suwon, Kyeonggi-do, Republic of Korea.

ABSTRACT

Purpose: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.

Materials and methods: We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, V(nGy), D(min), D(max), radiation conformality index (RCI), and radical dose homogeneity index (rDHI).

Results: The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V(23.25Gy), V(26.25Gy), V(27.5Gy), and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.

Conclusions: Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

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Tomotherapy significantly reduced the V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, and V10Gy value of the small bowel as compared to 3D-CRT. However, the V5Gy value which had been associated with the low irradiation range of the normal tissue was not significantly different between the two modalities.
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Figure 2: Tomotherapy significantly reduced the V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, and V10Gy value of the small bowel as compared to 3D-CRT. However, the V5Gy value which had been associated with the low irradiation range of the normal tissue was not significantly different between the two modalities.

Mentions: We investigated the dosimetric parameters of the small bowel, which is the most critical organ in the rectal cancer patients who received the preoperative pelvic irradiation. Table 3 summarizes the V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, V10Gy, and V5Gy values of the small bowel with Tomotherapy and 3D-CRT. Tomotherapy produced significantly lower V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, and V10Gy values for the small bowel as compared to the 3D-CRT. However, the V5Gy value, which reflected the low irradiation range of the normal tissue, was not significantly different between Tomotherapy and 3D-CRT (Figure 2).


A comparison of dosimetric parameters between tomotherapy and three-dimensional conformal radiotherapy in rectal cancer.

Yu M, Lee JH, Jang HS, Jeon DM, Cheon JS, Lee HC, Lee JH - Radiat Oncol (2013)

Tomotherapy significantly reduced the V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, and V10Gy value of the small bowel as compared to 3D-CRT. However, the V5Gy value which had been associated with the low irradiation range of the normal tissue was not significantly different between the two modalities.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3721992&req=5

Figure 2: Tomotherapy significantly reduced the V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, and V10Gy value of the small bowel as compared to 3D-CRT. However, the V5Gy value which had been associated with the low irradiation range of the normal tissue was not significantly different between the two modalities.
Mentions: We investigated the dosimetric parameters of the small bowel, which is the most critical organ in the rectal cancer patients who received the preoperative pelvic irradiation. Table 3 summarizes the V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, V10Gy, and V5Gy values of the small bowel with Tomotherapy and 3D-CRT. Tomotherapy produced significantly lower V25Gy, V22.5Gy, V20Gy, V17.5Gy , V15Gy, and V10Gy values for the small bowel as compared to the 3D-CRT. However, the V5Gy value, which reflected the low irradiation range of the normal tissue, was not significantly different between Tomotherapy and 3D-CRT (Figure 2).

Bottom Line: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs).Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiation Oncology, St, Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Ji-dong Paldal-gu, Suwon, Kyeonggi-do, Republic of Korea.

ABSTRACT

Purpose: Tomotherapy for intensity-modulated radiation has been demonstrated to reduce unnecessary irradiations to adjacent organs at risk (OARs). The purpose of this study was to compare the dosimetric parameters between Tomotherapy and three-dimensional conformal radiotherapy (3D-CRT) in rectal cancer patients.

Materials and methods: We redesigned three-dimensional conformal plans for 20 rectal cancer patients who had received short-course preoperative radiotherapy with Tomotherapy. The target coverage for 3D-CRT and Tomotherapy was evaluated with the following including the mean dose, V(nGy), D(min), D(max), radiation conformality index (RCI), and radical dose homogeneity index (rDHI).

Results: The mean PTV dose for Tomotherapy is significantly higher than that observed for the 3D-CRT (p = 0.043). However, there is no significant difference in the V(23.25Gy), V(26.25Gy), V(27.5Gy), and RCI values between Tomotherapy and 3D-CRT. However, the average rDHI (p < 0.001) value for Tomotherapy was significantly lower than that reported for the 3D-CRT. Tomotherapy significantly lowered the mean level of irradiation doses to the bladder, small bowel, and femur heads as compared to 3D-CRT.

Conclusions: Tomotherapy could produce a favorable target coverage and significant dose reduction for the OARs at the expense of acceptable dose inhomogeneity of the PTV compared with 3D-CRT in rectal cancer patients.

Show MeSH
Related in: MedlinePlus