Limits...
CEPHEUS SA: a South African survey on the undertreatment of hypercholesterolaemia.

Raal F, Schamroth C, Blom D, Marx J, Rajput M, Haus M, Hussain R, Cassim F, Nortjé M, Vandehoven G, Temmerman AM - Cardiovasc J Afr (2011)

Bottom Line: The mean age was 59.4 years, and 47.5% were female.Being male, older than 40 years, falling into the lower-risk categories, compliance with the medication regimen, and patient knowledge that the LDL-C goal had been reached, were associated with the highest probability of attaining LDL-C goals.The results of this survey highlight the sub-optimal lipid control achieved in many South African patients taking lipid-lowering therapy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. Frederick.raal@wits.ac.za

ABSTRACT

Aim: The aim of the CEntralised Pan-South African survey on tHE Under-treatment of hypercholeSterolaemia (CEPHEUS SA) was to evaluate the current use and efficacy of lipidlowering drugs (LLDs), and to identify possible patient and physician characteristics associated with failure, if any, to achieve low-density lipoprotein cholesterol (LDL-C) targets.

Methods: The survey was conducted in 69 study centres in South Africa and recruited consecutive consenting patients who had been prescribed LLDs for at least three months. One visit was scheduled for data collection, including fasting plasma lipid and glucose levels. Physicians and patients completed questionnaires regarding their knowledge, awareness and perceptions of hypercholesterolaemia and the treatment thereof.

Results: Of the 3 001 patients recruited, 2 996 were included in the final analyses. The mean age was 59.4 years, and 47.5% were female. Only 60.5 and 52.3% of patients on LLDs for at least three months achieved the LDL-C target recommended by the NCEP ATP III/2004 updated NCEP ATP III and the Fourth JETF/South African guidelines, respectively. Being male, older than 40 years, falling into the lower-risk categories, compliance with the medication regimen, and patient knowledge that the LDL-C goal had been reached, were associated with the highest probability of attaining LDL-C goals.

Conclusion: The results of this survey highlight the sub-optimal lipid control achieved in many South African patients taking lipid-lowering therapy.

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Related in: MedlinePlus

Use of guidelines to establish individual target cholesterol levels.
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Figure 1: Use of guidelines to establish individual target cholesterol levels.

Mentions: Most investigators (n = 96; 95.0%) use guidelines to establish individual target cholesterol levels, with the National South African guidelines and the NCEP ATP III guidelines (Framingham) being the most frequently used by 50.0% and 35.9% of investigators, respectively (Fig. 1). Other less-used guidelines were: Joint European guideline (SCORE) (n = 22; 23.9%), individual practice guidelines (n = 12; 13.0%), funder formularies (n = 10; 10.9%), other guidelines (n = 6, 6.5%) and local healthcare authority guidelines (n = 4; 4.3%) (Fig. 2).


CEPHEUS SA: a South African survey on the undertreatment of hypercholesterolaemia.

Raal F, Schamroth C, Blom D, Marx J, Rajput M, Haus M, Hussain R, Cassim F, Nortjé M, Vandehoven G, Temmerman AM - Cardiovasc J Afr (2011)

Use of guidelines to establish individual target cholesterol levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3721857&req=5

Figure 1: Use of guidelines to establish individual target cholesterol levels.
Mentions: Most investigators (n = 96; 95.0%) use guidelines to establish individual target cholesterol levels, with the National South African guidelines and the NCEP ATP III guidelines (Framingham) being the most frequently used by 50.0% and 35.9% of investigators, respectively (Fig. 1). Other less-used guidelines were: Joint European guideline (SCORE) (n = 22; 23.9%), individual practice guidelines (n = 12; 13.0%), funder formularies (n = 10; 10.9%), other guidelines (n = 6, 6.5%) and local healthcare authority guidelines (n = 4; 4.3%) (Fig. 2).

Bottom Line: The mean age was 59.4 years, and 47.5% were female.Being male, older than 40 years, falling into the lower-risk categories, compliance with the medication regimen, and patient knowledge that the LDL-C goal had been reached, were associated with the highest probability of attaining LDL-C goals.The results of this survey highlight the sub-optimal lipid control achieved in many South African patients taking lipid-lowering therapy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. Frederick.raal@wits.ac.za

ABSTRACT

Aim: The aim of the CEntralised Pan-South African survey on tHE Under-treatment of hypercholeSterolaemia (CEPHEUS SA) was to evaluate the current use and efficacy of lipidlowering drugs (LLDs), and to identify possible patient and physician characteristics associated with failure, if any, to achieve low-density lipoprotein cholesterol (LDL-C) targets.

Methods: The survey was conducted in 69 study centres in South Africa and recruited consecutive consenting patients who had been prescribed LLDs for at least three months. One visit was scheduled for data collection, including fasting plasma lipid and glucose levels. Physicians and patients completed questionnaires regarding their knowledge, awareness and perceptions of hypercholesterolaemia and the treatment thereof.

Results: Of the 3 001 patients recruited, 2 996 were included in the final analyses. The mean age was 59.4 years, and 47.5% were female. Only 60.5 and 52.3% of patients on LLDs for at least three months achieved the LDL-C target recommended by the NCEP ATP III/2004 updated NCEP ATP III and the Fourth JETF/South African guidelines, respectively. Being male, older than 40 years, falling into the lower-risk categories, compliance with the medication regimen, and patient knowledge that the LDL-C goal had been reached, were associated with the highest probability of attaining LDL-C goals.

Conclusion: The results of this survey highlight the sub-optimal lipid control achieved in many South African patients taking lipid-lowering therapy.

Show MeSH
Related in: MedlinePlus