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Role of four-week resistance exercise in preserving the heart against ischaemia-reperfusion-induced injury.

Doustar Y, Soufi FG, Jafary A, Saber MM, Ghiassie R - Cardiovasc J Afr (2012)

Bottom Line: While diastolic pressure increased and developed pressure and coronary flow decreased in both the ischaemic and perfusion periods (as indices of cardiac damage), there were no statistically significant differences between the trained and sedentary groups in these parameters.We did not see a cardioprotective effect of resistance exercise against ischaemia-reperfusion-induced injury in this study.A precise conclusion about this issue needs more investigations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Islamic Azad University (Tabriz branch), Tabriz, Iran. Dr.Dustar@gmail.com

ABSTRACT

Objective: We studied the cardioprotective effect of resistance training against ischaemia-reperfusion-induced injury.

Methods: Forty male rats were divided into trained and sedentary groups (n = 20 for each). The trained rats were exercised at 12 repetitions/set, four sets/day and five days/week for four weeks. Transient regional ischaemia of the left anterior descending coronary artery (40 min) was followed by 80 min of reperfusion.

Results: Baseline developed and diastolic pressures and coronary flow were similar in the two groups. While diastolic pressure increased and developed pressure and coronary flow decreased in both the ischaemic and perfusion periods (as indices of cardiac damage), there were no statistically significant differences between the trained and sedentary groups in these parameters. Resistance training did not significantly change the infarct size and apoptosis rate.

Conclusion: We did not see a cardioprotective effect of resistance exercise against ischaemia-reperfusion-induced injury in this study. A precise conclusion about this issue needs more investigations.

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Related in: MedlinePlus

Effect of resistance exercise on the heart infarct size. Top: representative digital images of the stained heart. Non-necrotic viable tissue is dark, and infracted tissue is light. Bottom: quantification of average infarct size expressed as a percentage of ischaemic ZAR (zone at risk). Values are mean ± SD (n = 6 rats); Sed: sedentary and EXT: exercise-trained rats.
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Figure 3: Effect of resistance exercise on the heart infarct size. Top: representative digital images of the stained heart. Non-necrotic viable tissue is dark, and infracted tissue is light. Bottom: quantification of average infarct size expressed as a percentage of ischaemic ZAR (zone at risk). Values are mean ± SD (n = 6 rats); Sed: sedentary and EXT: exercise-trained rats.

Mentions: Figs 3 and 4 show the size of the infarction and the apoptosis rate, respectively in the hearts of the EXT and Sed groups. Resistance exercise training did not significantly change the infarct size or apoptosis rate.


Role of four-week resistance exercise in preserving the heart against ischaemia-reperfusion-induced injury.

Doustar Y, Soufi FG, Jafary A, Saber MM, Ghiassie R - Cardiovasc J Afr (2012)

Effect of resistance exercise on the heart infarct size. Top: representative digital images of the stained heart. Non-necrotic viable tissue is dark, and infracted tissue is light. Bottom: quantification of average infarct size expressed as a percentage of ischaemic ZAR (zone at risk). Values are mean ± SD (n = 6 rats); Sed: sedentary and EXT: exercise-trained rats.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3721821&req=5

Figure 3: Effect of resistance exercise on the heart infarct size. Top: representative digital images of the stained heart. Non-necrotic viable tissue is dark, and infracted tissue is light. Bottom: quantification of average infarct size expressed as a percentage of ischaemic ZAR (zone at risk). Values are mean ± SD (n = 6 rats); Sed: sedentary and EXT: exercise-trained rats.
Mentions: Figs 3 and 4 show the size of the infarction and the apoptosis rate, respectively in the hearts of the EXT and Sed groups. Resistance exercise training did not significantly change the infarct size or apoptosis rate.

Bottom Line: While diastolic pressure increased and developed pressure and coronary flow decreased in both the ischaemic and perfusion periods (as indices of cardiac damage), there were no statistically significant differences between the trained and sedentary groups in these parameters.We did not see a cardioprotective effect of resistance exercise against ischaemia-reperfusion-induced injury in this study.A precise conclusion about this issue needs more investigations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Islamic Azad University (Tabriz branch), Tabriz, Iran. Dr.Dustar@gmail.com

ABSTRACT

Objective: We studied the cardioprotective effect of resistance training against ischaemia-reperfusion-induced injury.

Methods: Forty male rats were divided into trained and sedentary groups (n = 20 for each). The trained rats were exercised at 12 repetitions/set, four sets/day and five days/week for four weeks. Transient regional ischaemia of the left anterior descending coronary artery (40 min) was followed by 80 min of reperfusion.

Results: Baseline developed and diastolic pressures and coronary flow were similar in the two groups. While diastolic pressure increased and developed pressure and coronary flow decreased in both the ischaemic and perfusion periods (as indices of cardiac damage), there were no statistically significant differences between the trained and sedentary groups in these parameters. Resistance training did not significantly change the infarct size and apoptosis rate.

Conclusion: We did not see a cardioprotective effect of resistance exercise against ischaemia-reperfusion-induced injury in this study. A precise conclusion about this issue needs more investigations.

Show MeSH
Related in: MedlinePlus