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Nitric oxide in the cardiovascular system: a simple molecule with complex actions.

Strijdom H, Chamane N, Lochner A - Cardiovasc J Afr (2009 Sep-Oct)

Bottom Line: However, due to various complex underlying cellular mechanisms, the actions of NO often seem to be contradictory.NO is a promising candidate molecule that could find therapeutic application.For this to be achieved, a sound understanding of this simple molecule and its complex actions is required.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, South Africa. jgstr@sun.ac.za

ABSTRACT
Since it was identified as the elusive endothelium-derived relaxing factor (EDRF) in the 1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling molecules in the cardiovascular system. Now, 20 years later, NO is regarded by most to be a ubiquitous mediator of cardioprotection. However, due to various complex underlying cellular mechanisms, the actions of NO often seem to be contradictory. This article sheds light on some of the mechanisms that may influence the variable actions of NO in the heart. Its role in conditions of oxygen deprivation (ischaemia and hypoxia) in particular is relevant to basic scientists and clinicians alike, since the prevalence of ischaemic heart disease is on the rise (in both the developed and the developing worlds) and novel therapeutic options are in constant demand. NO is a promising candidate molecule that could find therapeutic application. For this to be achieved, a sound understanding of this simple molecule and its complex actions is required.

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Variable biological effects of NO: possible mechanisms.
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Figure 3: Variable biological effects of NO: possible mechanisms.

Mentions: From the above, it is clear that there are many underlying mechanisms and physiological factors (see Fig. 3 for summary) that influence the biological actions of NO. The resulting complexity and variability of the effects and the difficulties they often create in the interpretation of findings make further research into the cellular mechanisms of this vital cardiovascular signalling molecule imperative.


Nitric oxide in the cardiovascular system: a simple molecule with complex actions.

Strijdom H, Chamane N, Lochner A - Cardiovasc J Afr (2009 Sep-Oct)

Variable biological effects of NO: possible mechanisms.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3721819&req=5

Figure 3: Variable biological effects of NO: possible mechanisms.
Mentions: From the above, it is clear that there are many underlying mechanisms and physiological factors (see Fig. 3 for summary) that influence the biological actions of NO. The resulting complexity and variability of the effects and the difficulties they often create in the interpretation of findings make further research into the cellular mechanisms of this vital cardiovascular signalling molecule imperative.

Bottom Line: However, due to various complex underlying cellular mechanisms, the actions of NO often seem to be contradictory.NO is a promising candidate molecule that could find therapeutic application.For this to be achieved, a sound understanding of this simple molecule and its complex actions is required.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, South Africa. jgstr@sun.ac.za

ABSTRACT
Since it was identified as the elusive endothelium-derived relaxing factor (EDRF) in the 1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling molecules in the cardiovascular system. Now, 20 years later, NO is regarded by most to be a ubiquitous mediator of cardioprotection. However, due to various complex underlying cellular mechanisms, the actions of NO often seem to be contradictory. This article sheds light on some of the mechanisms that may influence the variable actions of NO in the heart. Its role in conditions of oxygen deprivation (ischaemia and hypoxia) in particular is relevant to basic scientists and clinicians alike, since the prevalence of ischaemic heart disease is on the rise (in both the developed and the developing worlds) and novel therapeutic options are in constant demand. NO is a promising candidate molecule that could find therapeutic application. For this to be achieved, a sound understanding of this simple molecule and its complex actions is required.

Show MeSH
Related in: MedlinePlus