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Prevalence of asymptomatic left ventricular systolic dysfunction in hypertensive Nigerians: echocardiographic study of 832 subjects.

Ogah OS, Akinyemi RO, Adegbite GD, Udofia OI, Udoh SB, Adesina JO, Ojo OS, Alabi AA, Majekodunmi T, Osinfade JK, Ogundipe RF, Falase AO - Cardiovasc J Afr (2011 Nov-Dec)

Bottom Line: Data were obtained in 832 subjects (50.1% women) aged 56.0 ± 12.7 years (men 56.9 ± 13.3 years, women 55.0 ± 12.0 years, range 15-88).In a multivariate analysis, male gender, body mass index and LV mass were the predictors of LVSD.Early introduction of disease-modifying drugs in these patients, such as angiotensin converting enzyme inhibitors or angiotensin receptor blockers may retard or prevent the progression to overt heart failure.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Federal Medical Centre, Idi-Aba, Abeokuta, Ogun State, Nigeria.

ABSTRACT

Background: We sought to determine the prevalence of echocardiographically determined left ventricular systolic dysfunction in asymptomatic hypertensive subjects seen in Abeokuta, Nigeria.

Methods: Echocardiography was performed in 832 consecutive hypertensive subjects referred for cardiac evaluation over a three-year period.

Results: Data were obtained in 832 subjects (50.1% women) aged 56.0 ± 12.7 years (men 56.9 ± 13.3 years, women 55.0 ± 12.0 years, range 15-88). The prevalence of left ventricular systolic dysfunction (LVSD) was 18.1% in the study population (mild LVSD = 9.6%, moderate LVSD = 3.7% and severe LVSD = 4.8%). In a multivariate analysis, male gender, body mass index and LV mass were the predictors of LVSD.

Conclusion: Significant numbers of hypertensive subjects in this study had varying degrees of left ventricular systolic dysfunction. Early introduction of disease-modifying drugs in these patients, such as angiotensin converting enzyme inhibitors or angiotensin receptor blockers may retard or prevent the progression to overt heart failure.

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Histogram of the age distribution of the subjects.
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Figure 2: Histogram of the age distribution of the subjects.

Mentions: The overall mean age of the population was 56.0 ± 12.7 years (range 15–88). Fig. 2 is a histogram showing the age distribution of the subjects. The majority of the subjects fell within the middle-aged group, with a peak age of 50 years. Forty-six subjects (5.5%) had a self-reported history of diabetes (25 men, 6.0% and 21 women, 5.0%).


Prevalence of asymptomatic left ventricular systolic dysfunction in hypertensive Nigerians: echocardiographic study of 832 subjects.

Ogah OS, Akinyemi RO, Adegbite GD, Udofia OI, Udoh SB, Adesina JO, Ojo OS, Alabi AA, Majekodunmi T, Osinfade JK, Ogundipe RF, Falase AO - Cardiovasc J Afr (2011 Nov-Dec)

Histogram of the age distribution of the subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3721806&req=5

Figure 2: Histogram of the age distribution of the subjects.
Mentions: The overall mean age of the population was 56.0 ± 12.7 years (range 15–88). Fig. 2 is a histogram showing the age distribution of the subjects. The majority of the subjects fell within the middle-aged group, with a peak age of 50 years. Forty-six subjects (5.5%) had a self-reported history of diabetes (25 men, 6.0% and 21 women, 5.0%).

Bottom Line: Data were obtained in 832 subjects (50.1% women) aged 56.0 ± 12.7 years (men 56.9 ± 13.3 years, women 55.0 ± 12.0 years, range 15-88).In a multivariate analysis, male gender, body mass index and LV mass were the predictors of LVSD.Early introduction of disease-modifying drugs in these patients, such as angiotensin converting enzyme inhibitors or angiotensin receptor blockers may retard or prevent the progression to overt heart failure.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Federal Medical Centre, Idi-Aba, Abeokuta, Ogun State, Nigeria.

ABSTRACT

Background: We sought to determine the prevalence of echocardiographically determined left ventricular systolic dysfunction in asymptomatic hypertensive subjects seen in Abeokuta, Nigeria.

Methods: Echocardiography was performed in 832 consecutive hypertensive subjects referred for cardiac evaluation over a three-year period.

Results: Data were obtained in 832 subjects (50.1% women) aged 56.0 ± 12.7 years (men 56.9 ± 13.3 years, women 55.0 ± 12.0 years, range 15-88). The prevalence of left ventricular systolic dysfunction (LVSD) was 18.1% in the study population (mild LVSD = 9.6%, moderate LVSD = 3.7% and severe LVSD = 4.8%). In a multivariate analysis, male gender, body mass index and LV mass were the predictors of LVSD.

Conclusion: Significant numbers of hypertensive subjects in this study had varying degrees of left ventricular systolic dysfunction. Early introduction of disease-modifying drugs in these patients, such as angiotensin converting enzyme inhibitors or angiotensin receptor blockers may retard or prevent the progression to overt heart failure.

Show MeSH
Related in: MedlinePlus