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Prevalence of nontuberculous mycobacteria in cystic fibrosis clinics, United Kingdom, 2009.

Seddon P, Fidler K, Raman S, Wyatt H, Ruiz G, Elston C, Perrin F, Gyi K, Bilton D, Drobniewski F, Newport M - Emerging Infect. Dis. (2013)

Bottom Line: Incidence of pulmonary infection with nontuberculous mycobacteria (NTM) is increasing among persons with cystic fibrosis (CF).We assessed prevalence and management in CF centers in the United Kingdom and found 5.0% of 3,805 adults and 3.3% of 3,317 children had recently been diagnosed with NTM.Of those, 44% of adults and 47% of children received treatment.

View Article: PubMed Central - PubMed

Affiliation: Royal Alexandra Children’s Hospital, Brighton, UK. seddop@gmail.com

ABSTRACT
Incidence of pulmonary infection with nontuberculous mycobacteria (NTM) is increasing among persons with cystic fibrosis (CF). We assessed prevalence and management in CF centers in the United Kingdom and found 5.0% of 3,805 adults and 3.3% of 3,317 children had recently been diagnosed with NTM. Of those, 44% of adults and 47% of children received treatment.

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Regional variation in percentage of cystic fibrosis patients in whom nontuberculous mycobacteria were isolated, United Kingdom, 2009. Percentages represent combined clinics within participating regions. Nineteen of 23 adult and 24 of 29 pediatric CF centers, accounting for 7,122 of 8,513 (84%) CF patients, participated in the survey.
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Figure 1: Regional variation in percentage of cystic fibrosis patients in whom nontuberculous mycobacteria were isolated, United Kingdom, 2009. Percentages represent combined clinics within participating regions. Nineteen of 23 adult and 24 of 29 pediatric CF centers, accounting for 7,122 of 8,513 (84%) CF patients, participated in the survey.

Mentions: Twenty-three adult and 29 pediatric UK CF centers, with 8,513 CF patients, were sent questionnaires. Responses were received from 19 (83%) and 24 (83%) of these centers respectively, comprising 7,122 patients (3,805 adults, 3,317 children), or 84% of the UK CF population. As expected, the prevalence of any NTM isolate was higher in the adult (5.0%) than in the pediatric (3.3%) population (Table). Fifteen adult and 17 pediatric centers cultured samples for NTM yearly; most remaining centers tested for NTM only if there was a specific clinical indication. The NTM pathogens most frequently cultured were the rapidly growing MABSC (62% of adults, 68% of children who were NTM-positive), followed by MAC (28% of adults, 27% of children). Other species (M. gordonae, kansasii, xenopi, fortuitum, simiae, malmoense, mucogenicum, perigrinum) together made up 8% of the total. Wide geographic variation was noted, increasing from northwest to southeast, manifesting lowest prevalence in Northern Ireland (1.9%) and highest in South East England (7.5%) (Figure).


Prevalence of nontuberculous mycobacteria in cystic fibrosis clinics, United Kingdom, 2009.

Seddon P, Fidler K, Raman S, Wyatt H, Ruiz G, Elston C, Perrin F, Gyi K, Bilton D, Drobniewski F, Newport M - Emerging Infect. Dis. (2013)

Regional variation in percentage of cystic fibrosis patients in whom nontuberculous mycobacteria were isolated, United Kingdom, 2009. Percentages represent combined clinics within participating regions. Nineteen of 23 adult and 24 of 29 pediatric CF centers, accounting for 7,122 of 8,513 (84%) CF patients, participated in the survey.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3713964&req=5

Figure 1: Regional variation in percentage of cystic fibrosis patients in whom nontuberculous mycobacteria were isolated, United Kingdom, 2009. Percentages represent combined clinics within participating regions. Nineteen of 23 adult and 24 of 29 pediatric CF centers, accounting for 7,122 of 8,513 (84%) CF patients, participated in the survey.
Mentions: Twenty-three adult and 29 pediatric UK CF centers, with 8,513 CF patients, were sent questionnaires. Responses were received from 19 (83%) and 24 (83%) of these centers respectively, comprising 7,122 patients (3,805 adults, 3,317 children), or 84% of the UK CF population. As expected, the prevalence of any NTM isolate was higher in the adult (5.0%) than in the pediatric (3.3%) population (Table). Fifteen adult and 17 pediatric centers cultured samples for NTM yearly; most remaining centers tested for NTM only if there was a specific clinical indication. The NTM pathogens most frequently cultured were the rapidly growing MABSC (62% of adults, 68% of children who were NTM-positive), followed by MAC (28% of adults, 27% of children). Other species (M. gordonae, kansasii, xenopi, fortuitum, simiae, malmoense, mucogenicum, perigrinum) together made up 8% of the total. Wide geographic variation was noted, increasing from northwest to southeast, manifesting lowest prevalence in Northern Ireland (1.9%) and highest in South East England (7.5%) (Figure).

Bottom Line: Incidence of pulmonary infection with nontuberculous mycobacteria (NTM) is increasing among persons with cystic fibrosis (CF).We assessed prevalence and management in CF centers in the United Kingdom and found 5.0% of 3,805 adults and 3.3% of 3,317 children had recently been diagnosed with NTM.Of those, 44% of adults and 47% of children received treatment.

View Article: PubMed Central - PubMed

Affiliation: Royal Alexandra Children’s Hospital, Brighton, UK. seddop@gmail.com

ABSTRACT
Incidence of pulmonary infection with nontuberculous mycobacteria (NTM) is increasing among persons with cystic fibrosis (CF). We assessed prevalence and management in CF centers in the United Kingdom and found 5.0% of 3,805 adults and 3.3% of 3,317 children had recently been diagnosed with NTM. Of those, 44% of adults and 47% of children received treatment.

Show MeSH
Related in: MedlinePlus