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Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress.

Reshma AP, Arunachalam R, Pillai JK, Kurra SB, Varkey VK, Prince MJ - J Indian Soc Periodontol (2013)

Bottom Line: Significantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05).No significant difference were observed between salivary and plasma CgA levels.Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sree Mookambika Institute of Dental Sciences, Kulasekharam, Kanyakumari, Tamil Nadu, India.

ABSTRACT

Context: The psychosocial stress has long been regarded as a significant pre-disposing factor for periodontal disease. The association between the periodontal disease and the neuroendocrine hormones has been observed. Chromogranin A (CgA) is supposed to link the activity of the neuroendocrine system to local and systemic immune functions and to be related to periodontitis.

Aims: The aim of this study was to determine the CgA levels in saliva and plasma in periodontal health and disease and to assess their potential relationship to periodontitis.

Settings and designs: In this case-control study, the association between periodontal disease and stress marker has been assessed.

Materials and methods: SIXTY SUBJECTS WERE CHOSEN FOR THIS STUDY: With case group comprising of 30 subjects with chronic periodontitis and control group comprising of 30 healthy subjects. Salivary and plasma CgA levels were determined by ELISA technique. Clinical parameters included were plaque index, papillary bleeding index and clinical attachment loss and probing depth. Correlation analysis was calculated by independent sample t-test.

Results: Significantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05). No significant difference were observed between salivary and plasma CgA levels.

Conclusions: The elevated level CgA in the plasma and saliva of subjects with stress induced chronic periodontitis has yielded insights into biological plausible association between the psychosocial stress and chronic periodontitis. Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis.

No MeSH data available.


Related in: MedlinePlus

Comparison of mean plasma chromogranin A levels between case and control groups
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Figure 2: Comparison of mean plasma chromogranin A levels between case and control groups

Mentions: The clinical parameters of the case-control groups are shown in Table 1, Figure 1. The mean values for case and control groups are plaque index (2.41 ± 0.01 and 0.28 ± 0.01), papillary bleeding index (55.62 ± 0.72 and 6.27 ± 0.48), probing depth (6.76 ± 0.14and 1.23 ± 0.07), clinical attachment level (CAL) (6.93 ± 0.13 and 1.23 ± 0.07) respectively. The mean values were significantly higher in chronic periodontitis group than in the control group. The novel biomarker CgA levels between cases and controls [Table 2] showed a statistically significant difference with mean values 82.63 ± 0.2 ng/ml and 59.56 ± 0.24 ng/ml in plasma and (4.62 ± 0.13 pmol/ml and 0.12 ± 0.23 pmol/ml) in Saliva with P < 0.05 [Figures 2 and 3]. However, there is no significant difference between CgA levels in saliva and plasma.


Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress.

Reshma AP, Arunachalam R, Pillai JK, Kurra SB, Varkey VK, Prince MJ - J Indian Soc Periodontol (2013)

Comparison of mean plasma chromogranin A levels between case and control groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3713754&req=5

Figure 2: Comparison of mean plasma chromogranin A levels between case and control groups
Mentions: The clinical parameters of the case-control groups are shown in Table 1, Figure 1. The mean values for case and control groups are plaque index (2.41 ± 0.01 and 0.28 ± 0.01), papillary bleeding index (55.62 ± 0.72 and 6.27 ± 0.48), probing depth (6.76 ± 0.14and 1.23 ± 0.07), clinical attachment level (CAL) (6.93 ± 0.13 and 1.23 ± 0.07) respectively. The mean values were significantly higher in chronic periodontitis group than in the control group. The novel biomarker CgA levels between cases and controls [Table 2] showed a statistically significant difference with mean values 82.63 ± 0.2 ng/ml and 59.56 ± 0.24 ng/ml in plasma and (4.62 ± 0.13 pmol/ml and 0.12 ± 0.23 pmol/ml) in Saliva with P < 0.05 [Figures 2 and 3]. However, there is no significant difference between CgA levels in saliva and plasma.

Bottom Line: Significantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05).No significant difference were observed between salivary and plasma CgA levels.Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sree Mookambika Institute of Dental Sciences, Kulasekharam, Kanyakumari, Tamil Nadu, India.

ABSTRACT

Context: The psychosocial stress has long been regarded as a significant pre-disposing factor for periodontal disease. The association between the periodontal disease and the neuroendocrine hormones has been observed. Chromogranin A (CgA) is supposed to link the activity of the neuroendocrine system to local and systemic immune functions and to be related to periodontitis.

Aims: The aim of this study was to determine the CgA levels in saliva and plasma in periodontal health and disease and to assess their potential relationship to periodontitis.

Settings and designs: In this case-control study, the association between periodontal disease and stress marker has been assessed.

Materials and methods: SIXTY SUBJECTS WERE CHOSEN FOR THIS STUDY: With case group comprising of 30 subjects with chronic periodontitis and control group comprising of 30 healthy subjects. Salivary and plasma CgA levels were determined by ELISA technique. Clinical parameters included were plaque index, papillary bleeding index and clinical attachment loss and probing depth. Correlation analysis was calculated by independent sample t-test.

Results: Significantly higher CgA levels were found in saliva and plasma of patients with chronic periodontitis compared with healthy individuals (P < 0.05). No significant difference were observed between salivary and plasma CgA levels.

Conclusions: The elevated level CgA in the plasma and saliva of subjects with stress induced chronic periodontitis has yielded insights into biological plausible association between the psychosocial stress and chronic periodontitis. Thus, our results suggest that CgA is a useful biomarker for evaluating at least in part the etiopathogenesis of periodontitis.

No MeSH data available.


Related in: MedlinePlus