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Gene therapy in periodontics.

Chatterjee A, Singh N, Saluja M - J Indian Soc Periodontol (2013)

Bottom Line: Thus it may be used to replace a faulty gene, or to introduce a new gene whose function is to cure or to favorably modify the clinical course of a condition.It has a promising era in the field of periodontics.The tissue engineering approach reconstructs the natural target tissue by combining four elements namely: Scaffold, signaling molecules, cells and blood supply and thus can help in the reconstruction of damaged periodontium including cementum, gingival, periodontal ligament and bone.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

ABSTRACT
GENES are made of DNA - the code of life. They are made up of two types of base pair from different number of hydrogen bonds AT, GC which can be turned into instruction. Everyone inherits genes from their parents and passes them on in turn to their children. Every person's genes are different, and the changes in sequence determine the inherited differences between each of us. Some changes, usually in a single gene, may cause serious diseases. Gene therapy is 'the use of genes as medicine'. It involves the transfer of a therapeutic or working gene copy into specific cells of an individual in order to repair a faulty gene copy. Thus it may be used to replace a faulty gene, or to introduce a new gene whose function is to cure or to favorably modify the clinical course of a condition. It has a promising era in the field of periodontics. Gene therapy has been used as a mode of tissue engineering in periodontics. The tissue engineering approach reconstructs the natural target tissue by combining four elements namely: Scaffold, signaling molecules, cells and blood supply and thus can help in the reconstruction of damaged periodontium including cementum, gingival, periodontal ligament and bone.

No MeSH data available.


In vivo
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Related In: Results  -  Collection

License
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Figure 2: In vivo

Mentions: Approaches for regenerating tooth-supporting structures (A) Guided tissue regeneration uses a cell occlusive barrier membrane to restore periodontal tissues. (B) Alternatively, an example of gene therapy uses vector-encoding growth factors aimed at stimulating the regeneration of host cells derived from the periodontium [Figure 2].


Gene therapy in periodontics.

Chatterjee A, Singh N, Saluja M - J Indian Soc Periodontol (2013)

In vivo
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3713744&req=5

Figure 2: In vivo
Mentions: Approaches for regenerating tooth-supporting structures (A) Guided tissue regeneration uses a cell occlusive barrier membrane to restore periodontal tissues. (B) Alternatively, an example of gene therapy uses vector-encoding growth factors aimed at stimulating the regeneration of host cells derived from the periodontium [Figure 2].

Bottom Line: Thus it may be used to replace a faulty gene, or to introduce a new gene whose function is to cure or to favorably modify the clinical course of a condition.It has a promising era in the field of periodontics.The tissue engineering approach reconstructs the natural target tissue by combining four elements namely: Scaffold, signaling molecules, cells and blood supply and thus can help in the reconstruction of damaged periodontium including cementum, gingival, periodontal ligament and bone.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

ABSTRACT
GENES are made of DNA - the code of life. They are made up of two types of base pair from different number of hydrogen bonds AT, GC which can be turned into instruction. Everyone inherits genes from their parents and passes them on in turn to their children. Every person's genes are different, and the changes in sequence determine the inherited differences between each of us. Some changes, usually in a single gene, may cause serious diseases. Gene therapy is 'the use of genes as medicine'. It involves the transfer of a therapeutic or working gene copy into specific cells of an individual in order to repair a faulty gene copy. Thus it may be used to replace a faulty gene, or to introduce a new gene whose function is to cure or to favorably modify the clinical course of a condition. It has a promising era in the field of periodontics. Gene therapy has been used as a mode of tissue engineering in periodontics. The tissue engineering approach reconstructs the natural target tissue by combining four elements namely: Scaffold, signaling molecules, cells and blood supply and thus can help in the reconstruction of damaged periodontium including cementum, gingival, periodontal ligament and bone.

No MeSH data available.