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Management of severe ovarian hyperstimulation syndrome with thawed plasma.

Kamath MS, Joshi A, Kamath AM, Aleyamma T - J Hum Reprod Sci (2013)

Bottom Line: Severe ovarian hyperstimulation syndrome remains one of the life threatening complication of assisted reproductive technology.We report a case of refractory OHSS which was managed successfully using thawed plasma.Thawed plasma transfusion could be potential therapeutic option for managing patients with severe ovarian hyperstimulation not responding to conventional treatment.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Unit, Christian Medical College, Vellore, India.

ABSTRACT
Severe ovarian hyperstimulation syndrome remains one of the life threatening complication of assisted reproductive technology. In refractory cases of late ovarian hyperstimulation syndrome (OHSS), clinicians are left with limited therapeutic options. We report a case of refractory OHSS which was managed successfully using thawed plasma. Thawed plasma transfusion could be potential therapeutic option for managing patients with severe ovarian hyperstimulation not responding to conventional treatment.

No MeSH data available.


Related in: MedlinePlus

Ultrasound image showing twin gestation with enlarged ovaries and fluid in pouch of douglas
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Figure 1: Ultrasound image showing twin gestation with enlarged ovaries and fluid in pouch of douglas

Mentions: On post-retrieval, day 9, the patient presented with complaints of severe abdominal discomfort, vomiting, difficulty in breathing and decreased urine output. Her abdominal girth had increased from 72 cm to 84 cm. Her blood test revealed hemoconcentration (hematocrit was 54%), raised liver enzymes, and low sodium (122 mEq/L). An ultrasound of the abdomen revealed bilateral enlarged ovaries (right ovarian size was 11 × 10 × 9 cm and left ovarian size was 10 × 8 × 8 cm) with significant ascitis [Figure 1]. Chest X-ray (an abdominal shield was used) showed bilateral pleural effusion. The patient was diagnosed with severe OHSS and admitted to the intensive care unit. Intravenous fluid administration, analgesics, anti-emetics, and prophylactic anti-coagulation with low molecular weight heparin 2500 IU subcutaneously were initiated. After stabilization, patient underwent therapeutic pleural tap and ultrasound-guided abdominal paracentesis. A total of 2.5 L of ascitic fluid was drained. The patient's symptoms were relieved temporarily. The patient's clinical and biochemical parameters were monitored on a daily basis. The patient was advised to wear elastic stockings and high protein diet intake. Infusion of human albumin was also given once daily.


Management of severe ovarian hyperstimulation syndrome with thawed plasma.

Kamath MS, Joshi A, Kamath AM, Aleyamma T - J Hum Reprod Sci (2013)

Ultrasound image showing twin gestation with enlarged ovaries and fluid in pouch of douglas
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3713586&req=5

Figure 1: Ultrasound image showing twin gestation with enlarged ovaries and fluid in pouch of douglas
Mentions: On post-retrieval, day 9, the patient presented with complaints of severe abdominal discomfort, vomiting, difficulty in breathing and decreased urine output. Her abdominal girth had increased from 72 cm to 84 cm. Her blood test revealed hemoconcentration (hematocrit was 54%), raised liver enzymes, and low sodium (122 mEq/L). An ultrasound of the abdomen revealed bilateral enlarged ovaries (right ovarian size was 11 × 10 × 9 cm and left ovarian size was 10 × 8 × 8 cm) with significant ascitis [Figure 1]. Chest X-ray (an abdominal shield was used) showed bilateral pleural effusion. The patient was diagnosed with severe OHSS and admitted to the intensive care unit. Intravenous fluid administration, analgesics, anti-emetics, and prophylactic anti-coagulation with low molecular weight heparin 2500 IU subcutaneously were initiated. After stabilization, patient underwent therapeutic pleural tap and ultrasound-guided abdominal paracentesis. A total of 2.5 L of ascitic fluid was drained. The patient's symptoms were relieved temporarily. The patient's clinical and biochemical parameters were monitored on a daily basis. The patient was advised to wear elastic stockings and high protein diet intake. Infusion of human albumin was also given once daily.

Bottom Line: Severe ovarian hyperstimulation syndrome remains one of the life threatening complication of assisted reproductive technology.We report a case of refractory OHSS which was managed successfully using thawed plasma.Thawed plasma transfusion could be potential therapeutic option for managing patients with severe ovarian hyperstimulation not responding to conventional treatment.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Unit, Christian Medical College, Vellore, India.

ABSTRACT
Severe ovarian hyperstimulation syndrome remains one of the life threatening complication of assisted reproductive technology. In refractory cases of late ovarian hyperstimulation syndrome (OHSS), clinicians are left with limited therapeutic options. We report a case of refractory OHSS which was managed successfully using thawed plasma. Thawed plasma transfusion could be potential therapeutic option for managing patients with severe ovarian hyperstimulation not responding to conventional treatment.

No MeSH data available.


Related in: MedlinePlus