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Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals.

Chowdhury R, Guitart-Masip M, Lambert C, Dolan RJ, Düzel E - Neurobiol. Aging (2013)

Bottom Line: Normal aging is associated with a variable loss of dopamine neurons in the SN/VTA.Older, but not younger, participants with greater structural integrity of the SN/VTA and the adjacent subthalamic nucleus could overcome this asymmetry.We show that interindividual variability among healthy older adults of the structural integrity within the SN/VTA and subthalamic nucleus relates to effective acquisition of competing instrumental responses.

View Article: PubMed Central - PubMed

Affiliation: Institute of Cognitive Neuroscience, University College London, London, UK; Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK. rumana.chowdhury1979@gmail.com

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Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals.

Chowdhury R, Guitart-Masip M, Lambert C, Dolan RJ, Düzel E - Neurobiol. Aging (2013)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3713434&req=5

Bottom Line: Normal aging is associated with a variable loss of dopamine neurons in the SN/VTA.Older, but not younger, participants with greater structural integrity of the SN/VTA and the adjacent subthalamic nucleus could overcome this asymmetry.We show that interindividual variability among healthy older adults of the structural integrity within the SN/VTA and subthalamic nucleus relates to effective acquisition of competing instrumental responses.

View Article: PubMed Central - PubMed

Affiliation: Institute of Cognitive Neuroscience, University College London, London, UK; Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK. rumana.chowdhury1979@gmail.com

Show MeSH