Limits...
Chinese herbal medicine for the treatment of prehypertension.

Wang J, Feng B, Yang X, Liu W, Xiong X - Evid Based Complement Alternat Med (2013)

Bottom Line: Objectives.Electronic databases were searched until May, 2013.Inclusion Criteria.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.

ABSTRACT
Objectives. To assess the current clinical evidence of Chinese herbal medicine (CHM) for prehypertension. Search Strategy. Electronic databases were searched until May, 2013. Inclusion Criteria. We included randomized clinical trials testing CHM against life style intervention and no treatment, or combined with life style intervention against life style intervention. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. Five trials were included. Methodological quality of the trials was evaluated as generally low. Only 1 trial reported allocation sequence. No trial reported the allocation concealment, double blinding, placebo control, presample size estimation, intention to treat analysis, and drop-out. All the included trials were not multicenter and large scale. Although meta-analysis showed that CHM is superior to either life style intervention group or no treatment group in decreasing blood pressure, we are unable to draw a definite conclusion on the effect of CHM due to the poor research methods used in the reviewed trials. The safety of CHM is still uncertain. Conclusions. There is no evidence to show that CHM is effective and safe for prehypertension due to serious methodological flaw of the reviewed trials. Rigorously designed trials are warranted to confirm these results.

No MeSH data available.


Related in: MedlinePlus

Analyses of systolic blood pressure (SBP).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3713375&req=5

fig2: Analyses of systolic blood pressure (SBP).

Mentions: Three trials reported the effect of CHM plus life style intervention versus life style intervention [45, 46, 48]. When it comes to systolic blood pressure (SBP), 2 trials demonstrated better effect favoring CHM: Banxia baizhu tianma decoction mildly lowered SBP than life style intervention treatment [46]; tiao ping kang pill significantly lowered SBP than life style intervention treatment [48]. Meta-analysis showed beneficial effect on the combination group as compared to the life style intervention group (WMD: −0.81 [−1.16, −0.46]; P < 0.00001) (as shown in Figure 2).


Chinese herbal medicine for the treatment of prehypertension.

Wang J, Feng B, Yang X, Liu W, Xiong X - Evid Based Complement Alternat Med (2013)

Analyses of systolic blood pressure (SBP).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3713375&req=5

fig2: Analyses of systolic blood pressure (SBP).
Mentions: Three trials reported the effect of CHM plus life style intervention versus life style intervention [45, 46, 48]. When it comes to systolic blood pressure (SBP), 2 trials demonstrated better effect favoring CHM: Banxia baizhu tianma decoction mildly lowered SBP than life style intervention treatment [46]; tiao ping kang pill significantly lowered SBP than life style intervention treatment [48]. Meta-analysis showed beneficial effect on the combination group as compared to the life style intervention group (WMD: −0.81 [−1.16, −0.46]; P < 0.00001) (as shown in Figure 2).

Bottom Line: Objectives.Electronic databases were searched until May, 2013.Inclusion Criteria.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.

ABSTRACT
Objectives. To assess the current clinical evidence of Chinese herbal medicine (CHM) for prehypertension. Search Strategy. Electronic databases were searched until May, 2013. Inclusion Criteria. We included randomized clinical trials testing CHM against life style intervention and no treatment, or combined with life style intervention against life style intervention. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. Five trials were included. Methodological quality of the trials was evaluated as generally low. Only 1 trial reported allocation sequence. No trial reported the allocation concealment, double blinding, placebo control, presample size estimation, intention to treat analysis, and drop-out. All the included trials were not multicenter and large scale. Although meta-analysis showed that CHM is superior to either life style intervention group or no treatment group in decreasing blood pressure, we are unable to draw a definite conclusion on the effect of CHM due to the poor research methods used in the reviewed trials. The safety of CHM is still uncertain. Conclusions. There is no evidence to show that CHM is effective and safe for prehypertension due to serious methodological flaw of the reviewed trials. Rigorously designed trials are warranted to confirm these results.

No MeSH data available.


Related in: MedlinePlus