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Diabetic mastopathy: an uncommon complication of diabetes mellitus.

Kirby RX, Mitchell DI, Williams NP, Cornwall DA, Cawich SO - Case Rep Surg (2013)

Bottom Line: Results.A 33-year-old woman with type 1 diabetes had excision biopsy of a 2 cm breast lump.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Radiology, Anaesthesia and Intensive Care, University of the West Indies, Mona, Kingston 7, Jamaica.

ABSTRACT
Introduction. Whilst most consequences of diabetes mellitus are well recognized, breast-related complications remain obscure. The term diabetic mastopathy (DMP) attempts to describe the breast-related consequences of diabetes. Methods. We report the clinicopathologic findings in a patient with DMP and review the literature on this uncommon entity. Results. A 33-year-old woman with type 1 diabetes had excision biopsy of a 2 cm breast lump. Histopathologic evaluation revealed classic features of DMP: parenchymal fibrosis; keloid-like hyalinization of interlobular stroma; adipose tissue entrapment; lobular compression; dense chronic inflammatory cell infiltration; and lymphoid follicle formation. Conclusion. Clinicians should be aware of DMP as a differential for breast disease in women with uncontrolled diabetes.

No MeSH data available.


Related in: MedlinePlus

Microscopic images showing marked fibrosis and keloid-like hyalinization of interlobular stroma.
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fig3: Microscopic images showing marked fibrosis and keloid-like hyalinization of interlobular stroma.

Mentions: The excised mass was firm and irregular with a solid white cut surface on gross inspection (Figure 2). Microscopic examination revealed breast tissue with no evidence of malignancy. However, there was marked fibrosis and keloid-like hyalinization of the interlobular stroma (Figure 3), with entrapment of adipose tissue and compression of the ducts and lobules (Figure 4). In addition, there was a dense chronic periductal and perilobular inflammatory cell infiltration, associated with lymphoid follicle formation (Figure 5). These features are pathognomonic for DMP.


Diabetic mastopathy: an uncommon complication of diabetes mellitus.

Kirby RX, Mitchell DI, Williams NP, Cornwall DA, Cawich SO - Case Rep Surg (2013)

Microscopic images showing marked fibrosis and keloid-like hyalinization of interlobular stroma.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3713321&req=5

fig3: Microscopic images showing marked fibrosis and keloid-like hyalinization of interlobular stroma.
Mentions: The excised mass was firm and irregular with a solid white cut surface on gross inspection (Figure 2). Microscopic examination revealed breast tissue with no evidence of malignancy. However, there was marked fibrosis and keloid-like hyalinization of the interlobular stroma (Figure 3), with entrapment of adipose tissue and compression of the ducts and lobules (Figure 4). In addition, there was a dense chronic periductal and perilobular inflammatory cell infiltration, associated with lymphoid follicle formation (Figure 5). These features are pathognomonic for DMP.

Bottom Line: Results.A 33-year-old woman with type 1 diabetes had excision biopsy of a 2 cm breast lump.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Radiology, Anaesthesia and Intensive Care, University of the West Indies, Mona, Kingston 7, Jamaica.

ABSTRACT
Introduction. Whilst most consequences of diabetes mellitus are well recognized, breast-related complications remain obscure. The term diabetic mastopathy (DMP) attempts to describe the breast-related consequences of diabetes. Methods. We report the clinicopathologic findings in a patient with DMP and review the literature on this uncommon entity. Results. A 33-year-old woman with type 1 diabetes had excision biopsy of a 2 cm breast lump. Histopathologic evaluation revealed classic features of DMP: parenchymal fibrosis; keloid-like hyalinization of interlobular stroma; adipose tissue entrapment; lobular compression; dense chronic inflammatory cell infiltration; and lymphoid follicle formation. Conclusion. Clinicians should be aware of DMP as a differential for breast disease in women with uncontrolled diabetes.

No MeSH data available.


Related in: MedlinePlus