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Effect of the presence of brain-derived neurotrophic factor val(66)met polymorphism on the recovery in patients with acute subcortical stroke.

Kim WS, Lim JY, Shin JH, Park HK, Tan SA, Park KU, Paik NJ - Ann Rehabil Med (2013)

Bottom Line: The mRS scores at 1 and 3 months after discharge from the neurorehabilitation unit were compared between the groups.A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), thereby reflecting significant differences between the Met allele (+) group and the Met allele (-) group.There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

ABSTRACT

Objective: To investigate the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the recovery after subcortical stroke, using the modified Rankin Scale (mRS).

Methods: Subcortical stroke patients with copies of BDNF Val(66)Met polymorphism (n=7) were compared to their controls (n=7) without a copy of BDNF Val(66)Met polymorphism after matching for initial severity, location and type of stroke. The mRS scores at 1 and 3 months after discharge from the neurorehabilitation unit were compared between the groups.

Results: A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), thereby reflecting significant differences between the Met allele (+) group and the Met allele (-) group. There was a significant difference in mRS scores at 3 months post-discharge between the two groups (p=0.01) although no difference was evident in mRS scores at 1 month post-discharge between the two groups. There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group.

Conclusion: BDNF Val(66)Met polymorphism may be associated with worse functional outcome in Korean patients with subcortical stroke. Therefore, BDNF Val(66)Met polymorphism should be considered as an important prognostic factor for recovery and responses to rehabilitation therapies after stroke in Korean patients. There is a need for developing different rehabilitation strategies for the population with BDNF Val(66)Met polymorphism. Further studies assessing different outcomes for various functional domains of stroke recovery are needed to clarify the role of BDNF Val(66)Met polymorphism.

No MeSH data available.


Related in: MedlinePlus

Modified Rankin Scale (mRS) on admission to the rehabilitation unit, at 1 month post-discharge and 3 months post-discharge according to the presence of the Met allele. *p<0.017 with Bonferroni correction by student's t-test, †p<0.025 with Bonferroni correction by paired t-test.
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Figure 2: Modified Rankin Scale (mRS) on admission to the rehabilitation unit, at 1 month post-discharge and 3 months post-discharge according to the presence of the Met allele. *p<0.017 with Bonferroni correction by student's t-test, †p<0.025 with Bonferroni correction by paired t-test.

Mentions: A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24)=37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), reflecting a significant difference between the Met allele (+) group and the Met allele (-) group (Fig. 2). Post-hoc analysis with Student t-test at each time point with Bonferroni correction revealed a significant difference in mRS scores at 3 months post-discharge between the two groups (p=0.01), although no difference in mRS scores was evident at 1 month post-discharge between the two groups (Fig. 2). There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group (Fig. 2). In the Met allele (+) group, there were no significant improvements in mRS scores although a trend for improvement was evident (Fig. 2).


Effect of the presence of brain-derived neurotrophic factor val(66)met polymorphism on the recovery in patients with acute subcortical stroke.

Kim WS, Lim JY, Shin JH, Park HK, Tan SA, Park KU, Paik NJ - Ann Rehabil Med (2013)

Modified Rankin Scale (mRS) on admission to the rehabilitation unit, at 1 month post-discharge and 3 months post-discharge according to the presence of the Met allele. *p<0.017 with Bonferroni correction by student's t-test, †p<0.025 with Bonferroni correction by paired t-test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3713287&req=5

Figure 2: Modified Rankin Scale (mRS) on admission to the rehabilitation unit, at 1 month post-discharge and 3 months post-discharge according to the presence of the Met allele. *p<0.017 with Bonferroni correction by student's t-test, †p<0.025 with Bonferroni correction by paired t-test.
Mentions: A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24)=37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), reflecting a significant difference between the Met allele (+) group and the Met allele (-) group (Fig. 2). Post-hoc analysis with Student t-test at each time point with Bonferroni correction revealed a significant difference in mRS scores at 3 months post-discharge between the two groups (p=0.01), although no difference in mRS scores was evident at 1 month post-discharge between the two groups (Fig. 2). There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group (Fig. 2). In the Met allele (+) group, there were no significant improvements in mRS scores although a trend for improvement was evident (Fig. 2).

Bottom Line: The mRS scores at 1 and 3 months after discharge from the neurorehabilitation unit were compared between the groups.A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), thereby reflecting significant differences between the Met allele (+) group and the Met allele (-) group.There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group.

View Article: PubMed Central - PubMed

Affiliation: Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

ABSTRACT

Objective: To investigate the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the recovery after subcortical stroke, using the modified Rankin Scale (mRS).

Methods: Subcortical stroke patients with copies of BDNF Val(66)Met polymorphism (n=7) were compared to their controls (n=7) without a copy of BDNF Val(66)Met polymorphism after matching for initial severity, location and type of stroke. The mRS scores at 1 and 3 months after discharge from the neurorehabilitation unit were compared between the groups.

Results: A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), thereby reflecting significant differences between the Met allele (+) group and the Met allele (-) group. There was a significant difference in mRS scores at 3 months post-discharge between the two groups (p=0.01) although no difference was evident in mRS scores at 1 month post-discharge between the two groups. There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group.

Conclusion: BDNF Val(66)Met polymorphism may be associated with worse functional outcome in Korean patients with subcortical stroke. Therefore, BDNF Val(66)Met polymorphism should be considered as an important prognostic factor for recovery and responses to rehabilitation therapies after stroke in Korean patients. There is a need for developing different rehabilitation strategies for the population with BDNF Val(66)Met polymorphism. Further studies assessing different outcomes for various functional domains of stroke recovery are needed to clarify the role of BDNF Val(66)Met polymorphism.

No MeSH data available.


Related in: MedlinePlus