Limits...
Chemometric evaluation of the column classification system during the pharmaceutical analysis of lamotrigine and its related substances.

Szulfer J, Plenis A, Bączek T - Anal Bioanal Chem (2013)

Bottom Line: This paper investigates the performance of a column classification system developed at the Katholieke Universiteit Leuven applied to pharmaceutical chromatographic analyses.A ranking was built based on the F KUL value calculated against the selected reference column, then compared with the column test performance established for the stationary phases studied.Therefore, the system suitability test prescribed by the European Pharmacopoeia in order to distinguish between suitable or unsuitable columns for this analysis was evaluated.

View Article: PubMed Central - PubMed

Affiliation: Polpharma SA Pharmaceutical Works, Starogard Gdański, Poland.

ABSTRACT
This paper investigates the performance of a column classification system developed at the Katholieke Universiteit Leuven applied to pharmaceutical chromatographic analyses. The liquid chromatography assay of lamotrigine and related compounds was carried out according to the method prescribed in the European Pharmacopoeia monograph, using 28 brands of stationary phases. A ranking was built based on the F KUL value calculated against the selected reference column, then compared with the column test performance established for the stationary phases studied. Therefore, the system suitability test prescribed by the European Pharmacopoeia in order to distinguish between suitable or unsuitable columns for this analysis was evaluated. Moreover, it was examined whether the classes of the stationary phases, determined using test parameter results, contain either suitable or unsuitable supports for the lamotrigine separation. This assay was performed using chemometric a technique, namely factor analysis.

Show MeSH

Related in: MedlinePlus

Chemometric evaluation of the column classiffication system in pharmaceutical practice
© Copyright Policy - OpenAccess
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3713273&req=5

Figa: Chemometric evaluation of the column classiffication system in pharmaceutical practice


Chemometric evaluation of the column classification system during the pharmaceutical analysis of lamotrigine and its related substances.

Szulfer J, Plenis A, Bączek T - Anal Bioanal Chem (2013)

Chemometric evaluation of the column classiffication system in pharmaceutical practice
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3713273&req=5

Figa: Chemometric evaluation of the column classiffication system in pharmaceutical practice
Bottom Line: This paper investigates the performance of a column classification system developed at the Katholieke Universiteit Leuven applied to pharmaceutical chromatographic analyses.A ranking was built based on the F KUL value calculated against the selected reference column, then compared with the column test performance established for the stationary phases studied.Therefore, the system suitability test prescribed by the European Pharmacopoeia in order to distinguish between suitable or unsuitable columns for this analysis was evaluated.

View Article: PubMed Central - PubMed

Affiliation: Polpharma SA Pharmaceutical Works, Starogard Gdański, Poland.

ABSTRACT
This paper investigates the performance of a column classification system developed at the Katholieke Universiteit Leuven applied to pharmaceutical chromatographic analyses. The liquid chromatography assay of lamotrigine and related compounds was carried out according to the method prescribed in the European Pharmacopoeia monograph, using 28 brands of stationary phases. A ranking was built based on the F KUL value calculated against the selected reference column, then compared with the column test performance established for the stationary phases studied. Therefore, the system suitability test prescribed by the European Pharmacopoeia in order to distinguish between suitable or unsuitable columns for this analysis was evaluated. Moreover, it was examined whether the classes of the stationary phases, determined using test parameter results, contain either suitable or unsuitable supports for the lamotrigine separation. This assay was performed using chemometric a technique, namely factor analysis.

Show MeSH
Related in: MedlinePlus