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Seasonal Changes in Endotoxin Exposure and Its Relationship to Exhaled Nitric Oxide and Exhaled Breath Condensate pH Levels in Atopic and Healthy Children.

Wan GH, Yan DC, Tung TH, Tang CS, Liu CH - PLoS ONE (2013)

Bottom Line: Exhaled nitric oxide (eNO) levels, an inflammation indicator, are associated with the pH values of exhaled breath condensate (EBC).The eNO, EBC pH levels, and pulmonary function of the children were also determined.Strong relationships existed between endotoxin exposure and EBC pH values in children with allergic rhinitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Therapy, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

ABSTRACT
Endotoxin, a component of the cell walls of gram-negative bacteria, is a contaminant in organic dusts (house dust) and aerosols. In humans, small amounts of endotoxin may cause a local inflammatory response. Exhaled nitric oxide (eNO) levels, an inflammation indicator, are associated with the pH values of exhaled breath condensate (EBC). This study evaluated seasonal changes on indoor endotoxin concentrations in homes and the relationships between endotoxin exposure and eNO/EBC pH levels for healthy children and children with allergy-related respiratory diseases. In total, 34 children with allergy-related respiratory diseases and 24 healthy children were enrolled. Indoor air quality measurements and dust sample analysis for endotoxin were conducted once each season inside 58 surveyed homes. The eNO, EBC pH levels, and pulmonary function of the children were also determined. The highest endotoxin concentrations were on kitchen floors of homes of children with allergy-related respiratory diseases and healthy children, and on bedroom floors of homes of asthmatic children and healthy children. Seasonal changes existed in endotoxin concentrations in dust samples from homes of children with allergic rhinitis, with or without asthma, and in EBC pH values among healthy children and those with allergy-related respiratory diseases. Strong relationships existed between endotoxin exposure and EBC pH values in children with allergic rhinitis.

No MeSH data available.


Related in: MedlinePlus

Seasonal variation of endotoxin concentrations in dust samples of children’s homes.•: asthma (AS) group; ○: allergic rhinitis (AR) group; ▴: AS+AR group; ▵: control group. *: p<0.05; **: p<0.01.
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pone-0066785-g002: Seasonal variation of endotoxin concentrations in dust samples of children’s homes.•: asthma (AS) group; ○: allergic rhinitis (AR) group; ▴: AS+AR group; ▵: control group. *: p<0.05; **: p<0.01.

Mentions: A seasonal trend for variations in endotoxin concentrations only existed in the homes of both children with allergic rhinitis (337.6 EU/mg dust in spring; 650.4 EU/mg dust in summer; 527.8 EU/mg dust in autumn; and 399.0 EU/mg dust in winter; p = 0.015) and children with asthma and allergic rhinitis (446.0 EU/mg dust in spring; 913.5 EU/mg dust in summer; 541.0 EU/mg dust in autumn; and 390.2 EU/mg dust in winter; p<0.01; Fig. 2).


Seasonal Changes in Endotoxin Exposure and Its Relationship to Exhaled Nitric Oxide and Exhaled Breath Condensate pH Levels in Atopic and Healthy Children.

Wan GH, Yan DC, Tung TH, Tang CS, Liu CH - PLoS ONE (2013)

Seasonal variation of endotoxin concentrations in dust samples of children’s homes.•: asthma (AS) group; ○: allergic rhinitis (AR) group; ▴: AS+AR group; ▵: control group. *: p<0.05; **: p<0.01.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3686731&req=5

pone-0066785-g002: Seasonal variation of endotoxin concentrations in dust samples of children’s homes.•: asthma (AS) group; ○: allergic rhinitis (AR) group; ▴: AS+AR group; ▵: control group. *: p<0.05; **: p<0.01.
Mentions: A seasonal trend for variations in endotoxin concentrations only existed in the homes of both children with allergic rhinitis (337.6 EU/mg dust in spring; 650.4 EU/mg dust in summer; 527.8 EU/mg dust in autumn; and 399.0 EU/mg dust in winter; p = 0.015) and children with asthma and allergic rhinitis (446.0 EU/mg dust in spring; 913.5 EU/mg dust in summer; 541.0 EU/mg dust in autumn; and 390.2 EU/mg dust in winter; p<0.01; Fig. 2).

Bottom Line: Exhaled nitric oxide (eNO) levels, an inflammation indicator, are associated with the pH values of exhaled breath condensate (EBC).The eNO, EBC pH levels, and pulmonary function of the children were also determined.Strong relationships existed between endotoxin exposure and EBC pH values in children with allergic rhinitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Therapy, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

ABSTRACT
Endotoxin, a component of the cell walls of gram-negative bacteria, is a contaminant in organic dusts (house dust) and aerosols. In humans, small amounts of endotoxin may cause a local inflammatory response. Exhaled nitric oxide (eNO) levels, an inflammation indicator, are associated with the pH values of exhaled breath condensate (EBC). This study evaluated seasonal changes on indoor endotoxin concentrations in homes and the relationships between endotoxin exposure and eNO/EBC pH levels for healthy children and children with allergy-related respiratory diseases. In total, 34 children with allergy-related respiratory diseases and 24 healthy children were enrolled. Indoor air quality measurements and dust sample analysis for endotoxin were conducted once each season inside 58 surveyed homes. The eNO, EBC pH levels, and pulmonary function of the children were also determined. The highest endotoxin concentrations were on kitchen floors of homes of children with allergy-related respiratory diseases and healthy children, and on bedroom floors of homes of asthmatic children and healthy children. Seasonal changes existed in endotoxin concentrations in dust samples from homes of children with allergic rhinitis, with or without asthma, and in EBC pH values among healthy children and those with allergy-related respiratory diseases. Strong relationships existed between endotoxin exposure and EBC pH values in children with allergic rhinitis.

No MeSH data available.


Related in: MedlinePlus