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Stress Impact on Resting State Brain Networks.

Soares JM, Sampaio A, Ferreira LM, Santos NC, Marques P, Marques F, Palha JA, Cerqueira JJ, Sousa N - PLoS ONE (2013)

Bottom Line: Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance.Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls.These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

View Article: PubMed Central - PubMed

Affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal ; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal ; Clinical Academic Center - Braga, Portugal.

ABSTRACT
Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance. Herein we assessed the architecture of the RSNs using functional magnetic resonance imaging (fMRI) in a cohort of participants exposed to prolonged stress (participants that had just finished their long period of preparation for the medical residence selection exam), and respective gender- and age-matched controls (medical students under normal academic activities). Analysis focused on the pattern of activity in resting state conditions and after deactivation. A volumetric estimation of the RSNs was also performed. Data shows that stressed participants displayed greater activation of the default mode (DMN), dorsal attention (DAN), ventral attention (VAN), sensorimotor (SMN), and primary visual (VN) networks than controls. Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls. These functional changes are paralleled by a constriction of the DMN that is in line with the pattern of brain atrophy observed after stress exposure. These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

No MeSH data available.


Related in: MedlinePlus

Volumetric Changes in the default mode network (DMN) after stress exposure.(A) Schematic representation of global DMN volumetric changes. (B) Regional volumetric differences in the DMN between Stress and Control groups. *P<0.05.
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pone-0066500-g004: Volumetric Changes in the default mode network (DMN) after stress exposure.(A) Schematic representation of global DMN volumetric changes. (B) Regional volumetric differences in the DMN between Stress and Control groups. *P<0.05.

Mentions: Whole brain analysis for relative intracranial volumes did not differ between experimental groups. However, a significant reduction (p<0.014) in total DMN volume (corrected ICV) was seen in stressed participants compared to controls (Figure 4). Specific areas of contraction were observed in the left pCC (p<0.025) and the left and right parietal inferior (p<0.024 and p<0.016, respectively). No significant areas of constriction or expansion were found in the dorsal and ventral attention in the SMN and primary VN (p = 0.86, p = 0.55, p = 0.87 and p = 0.67, respectively) between experimental groups.


Stress Impact on Resting State Brain Networks.

Soares JM, Sampaio A, Ferreira LM, Santos NC, Marques P, Marques F, Palha JA, Cerqueira JJ, Sousa N - PLoS ONE (2013)

Volumetric Changes in the default mode network (DMN) after stress exposure.(A) Schematic representation of global DMN volumetric changes. (B) Regional volumetric differences in the DMN between Stress and Control groups. *P<0.05.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3686683&req=5

pone-0066500-g004: Volumetric Changes in the default mode network (DMN) after stress exposure.(A) Schematic representation of global DMN volumetric changes. (B) Regional volumetric differences in the DMN between Stress and Control groups. *P<0.05.
Mentions: Whole brain analysis for relative intracranial volumes did not differ between experimental groups. However, a significant reduction (p<0.014) in total DMN volume (corrected ICV) was seen in stressed participants compared to controls (Figure 4). Specific areas of contraction were observed in the left pCC (p<0.025) and the left and right parietal inferior (p<0.024 and p<0.016, respectively). No significant areas of constriction or expansion were found in the dorsal and ventral attention in the SMN and primary VN (p = 0.86, p = 0.55, p = 0.87 and p = 0.67, respectively) between experimental groups.

Bottom Line: Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance.Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls.These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

View Article: PubMed Central - PubMed

Affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal ; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal ; Clinical Academic Center - Braga, Portugal.

ABSTRACT
Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance. Herein we assessed the architecture of the RSNs using functional magnetic resonance imaging (fMRI) in a cohort of participants exposed to prolonged stress (participants that had just finished their long period of preparation for the medical residence selection exam), and respective gender- and age-matched controls (medical students under normal academic activities). Analysis focused on the pattern of activity in resting state conditions and after deactivation. A volumetric estimation of the RSNs was also performed. Data shows that stressed participants displayed greater activation of the default mode (DMN), dorsal attention (DAN), ventral attention (VAN), sensorimotor (SMN), and primary visual (VN) networks than controls. Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls. These functional changes are paralleled by a constriction of the DMN that is in line with the pattern of brain atrophy observed after stress exposure. These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

No MeSH data available.


Related in: MedlinePlus