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Stress Impact on Resting State Brain Networks.

Soares JM, Sampaio A, Ferreira LM, Santos NC, Marques P, Marques F, Palha JA, Cerqueira JJ, Sousa N - PLoS ONE (2013)

Bottom Line: Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance.Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls.These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

View Article: PubMed Central - PubMed

Affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal ; ICVS/3B's - PT Government Associate Laboratory, Braga/GuimarĂ£es, Portugal ; Clinical Academic Center - Braga, Portugal.

ABSTRACT
Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance. Herein we assessed the architecture of the RSNs using functional magnetic resonance imaging (fMRI) in a cohort of participants exposed to prolonged stress (participants that had just finished their long period of preparation for the medical residence selection exam), and respective gender- and age-matched controls (medical students under normal academic activities). Analysis focused on the pattern of activity in resting state conditions and after deactivation. A volumetric estimation of the RSNs was also performed. Data shows that stressed participants displayed greater activation of the default mode (DMN), dorsal attention (DAN), ventral attention (VAN), sensorimotor (SMN), and primary visual (VN) networks than controls. Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls. These functional changes are paralleled by a constriction of the DMN that is in line with the pattern of brain atrophy observed after stress exposure. These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

No MeSH data available.


Related in: MedlinePlus

The impact of stress in Resting State Networks (RSNs) during task-induced deactivations.The images illustrate areas of increased deactivation in controls when compared to stressed participants in the default mode network (DMN) (A), dorsal attention network (DAN) (B), ventral attention network (VAN) (C), sensorimotor network (SMN) (D) and visual network (VN) (E), extracted by general linear model analysis and using two-sample t-tests, with results considered significant at a corrected for multiple comparisons p<0.05 threshold. Importantly, no areas of increased deactivation of these RSNs were found in stressed individuals when compared to controls.
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pone-0066500-g003: The impact of stress in Resting State Networks (RSNs) during task-induced deactivations.The images illustrate areas of increased deactivation in controls when compared to stressed participants in the default mode network (DMN) (A), dorsal attention network (DAN) (B), ventral attention network (VAN) (C), sensorimotor network (SMN) (D) and visual network (VN) (E), extracted by general linear model analysis and using two-sample t-tests, with results considered significant at a corrected for multiple comparisons p<0.05 threshold. Importantly, no areas of increased deactivation of these RSNs were found in stressed individuals when compared to controls.

Mentions: In task-induced deactivations, increased deactivations in DMN, both attention networks, SMN and VN were found in controls compared to stressed participants (Figure 3 and Table 2). More specifically, increased deactivations in the left middle occipital, angular and in the pCUN, middle occipital and temporal and parahippocampal right was found in DMN of controls when compared to stress participants (Table 2). In DAN, controls presented higher functional deactivation in the inferior temporal and superior parietal (Table 2). Controls showed an increased deactivation of the VAN, specifically in the left angular and inferior parietal and temporal, compared to stressed participants (Table 2). In SMN, controls presented higher functional deactivation in the cerebellum and in the left precentral (Table 2). Left calcarine was highly deactivated in controls compared to stress participants in the VN (Table 2). No significant region was found to display greater deactivation in stressed participants than in controls in any of the studied RSNs.


Stress Impact on Resting State Brain Networks.

Soares JM, Sampaio A, Ferreira LM, Santos NC, Marques P, Marques F, Palha JA, Cerqueira JJ, Sousa N - PLoS ONE (2013)

The impact of stress in Resting State Networks (RSNs) during task-induced deactivations.The images illustrate areas of increased deactivation in controls when compared to stressed participants in the default mode network (DMN) (A), dorsal attention network (DAN) (B), ventral attention network (VAN) (C), sensorimotor network (SMN) (D) and visual network (VN) (E), extracted by general linear model analysis and using two-sample t-tests, with results considered significant at a corrected for multiple comparisons p<0.05 threshold. Importantly, no areas of increased deactivation of these RSNs were found in stressed individuals when compared to controls.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3686683&req=5

pone-0066500-g003: The impact of stress in Resting State Networks (RSNs) during task-induced deactivations.The images illustrate areas of increased deactivation in controls when compared to stressed participants in the default mode network (DMN) (A), dorsal attention network (DAN) (B), ventral attention network (VAN) (C), sensorimotor network (SMN) (D) and visual network (VN) (E), extracted by general linear model analysis and using two-sample t-tests, with results considered significant at a corrected for multiple comparisons p<0.05 threshold. Importantly, no areas of increased deactivation of these RSNs were found in stressed individuals when compared to controls.
Mentions: In task-induced deactivations, increased deactivations in DMN, both attention networks, SMN and VN were found in controls compared to stressed participants (Figure 3 and Table 2). More specifically, increased deactivations in the left middle occipital, angular and in the pCUN, middle occipital and temporal and parahippocampal right was found in DMN of controls when compared to stress participants (Table 2). In DAN, controls presented higher functional deactivation in the inferior temporal and superior parietal (Table 2). Controls showed an increased deactivation of the VAN, specifically in the left angular and inferior parietal and temporal, compared to stressed participants (Table 2). In SMN, controls presented higher functional deactivation in the cerebellum and in the left precentral (Table 2). Left calcarine was highly deactivated in controls compared to stress participants in the VN (Table 2). No significant region was found to display greater deactivation in stressed participants than in controls in any of the studied RSNs.

Bottom Line: Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance.Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls.These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

View Article: PubMed Central - PubMed

Affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal ; ICVS/3B's - PT Government Associate Laboratory, Braga/GuimarĂ£es, Portugal ; Clinical Academic Center - Braga, Portugal.

ABSTRACT
Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance. Herein we assessed the architecture of the RSNs using functional magnetic resonance imaging (fMRI) in a cohort of participants exposed to prolonged stress (participants that had just finished their long period of preparation for the medical residence selection exam), and respective gender- and age-matched controls (medical students under normal academic activities). Analysis focused on the pattern of activity in resting state conditions and after deactivation. A volumetric estimation of the RSNs was also performed. Data shows that stressed participants displayed greater activation of the default mode (DMN), dorsal attention (DAN), ventral attention (VAN), sensorimotor (SMN), and primary visual (VN) networks than controls. Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls. These functional changes are paralleled by a constriction of the DMN that is in line with the pattern of brain atrophy observed after stress exposure. These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.

No MeSH data available.


Related in: MedlinePlus