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Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model.

Rajian JR, Shao X, Chamberland DL, Wang X - Biomed Opt Express (2013)

Bottom Line: In this work, we investigated the feasibility of PAI to measure angiogenesis, for the purpose of evaluating and monitoring inflammatory arthritis and responses to treatment.The imaging results on an arthritis rat model demonstrate that 1) there is noticeable enhancement in image intensities in the arthritic ankle joints when compared to the normal joints, and 2) there is noticeable decrease in image intensities in the arthritic ankle joints after treatment when compared to the untreated arthritic joints.In order to validate the findings from PAI, we performed positron emission tomography (PET) and histology on the same joints.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

ABSTRACT
Neovascularity also known as angiogenesis is an early feature of inflammatory arthritis disease. Therefore, identifying the development of neovascularity is one way to potentially detect and characterize arthritis. Laser-based photoacoustic imaging (PAI) is an emerging biomedical imaging modality which may aid in the detection of both early and continued development of neovascularity. In this work, we investigated the feasibility of PAI to measure angiogenesis, for the purpose of evaluating and monitoring inflammatory arthritis and responses to treatment. The imaging results on an arthritis rat model demonstrate that 1) there is noticeable enhancement in image intensities in the arthritic ankle joints when compared to the normal joints, and 2) there is noticeable decrease in image intensities in the arthritic ankle joints after treatment when compared to the untreated arthritic joints. In order to validate the findings from PAI, we performed positron emission tomography (PET) and histology on the same joints. The diameters of the ankle joints, as a clinical score of the arthritis, were also measured at each time point.

No MeSH data available.


Related in: MedlinePlus

PAI and US dual-modality imaging of a rat ankle joint affected by AIA. (A) Gray-scale PAI image. (B) Gray-scale US image. (C) Pseudo-color PAI image superimposed on the gray-scale US image.
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g002: PAI and US dual-modality imaging of a rat ankle joint affected by AIA. (A) Gray-scale PAI image. (B) Gray-scale US image. (C) Pseudo-color PAI image superimposed on the gray-scale US image.

Mentions: Typical PAI and US images of an arthritic ankle joint are given in Fig. 2Fig. 2


Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model.

Rajian JR, Shao X, Chamberland DL, Wang X - Biomed Opt Express (2013)

PAI and US dual-modality imaging of a rat ankle joint affected by AIA. (A) Gray-scale PAI image. (B) Gray-scale US image. (C) Pseudo-color PAI image superimposed on the gray-scale US image.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3675868&req=5

g002: PAI and US dual-modality imaging of a rat ankle joint affected by AIA. (A) Gray-scale PAI image. (B) Gray-scale US image. (C) Pseudo-color PAI image superimposed on the gray-scale US image.
Mentions: Typical PAI and US images of an arthritic ankle joint are given in Fig. 2Fig. 2

Bottom Line: In this work, we investigated the feasibility of PAI to measure angiogenesis, for the purpose of evaluating and monitoring inflammatory arthritis and responses to treatment.The imaging results on an arthritis rat model demonstrate that 1) there is noticeable enhancement in image intensities in the arthritic ankle joints when compared to the normal joints, and 2) there is noticeable decrease in image intensities in the arthritic ankle joints after treatment when compared to the untreated arthritic joints.In order to validate the findings from PAI, we performed positron emission tomography (PET) and histology on the same joints.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

ABSTRACT
Neovascularity also known as angiogenesis is an early feature of inflammatory arthritis disease. Therefore, identifying the development of neovascularity is one way to potentially detect and characterize arthritis. Laser-based photoacoustic imaging (PAI) is an emerging biomedical imaging modality which may aid in the detection of both early and continued development of neovascularity. In this work, we investigated the feasibility of PAI to measure angiogenesis, for the purpose of evaluating and monitoring inflammatory arthritis and responses to treatment. The imaging results on an arthritis rat model demonstrate that 1) there is noticeable enhancement in image intensities in the arthritic ankle joints when compared to the normal joints, and 2) there is noticeable decrease in image intensities in the arthritic ankle joints after treatment when compared to the untreated arthritic joints. In order to validate the findings from PAI, we performed positron emission tomography (PET) and histology on the same joints. The diameters of the ankle joints, as a clinical score of the arthritis, were also measured at each time point.

No MeSH data available.


Related in: MedlinePlus