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Simultaneous spatial and temporal focusing for tissue ablation.

Block E, Greco M, Vitek D, Masihzadeh O, Ammar DA, Kahook MY, Mandava N, Durfee C, Squier J - Biomed Opt Express (2013)

Bottom Line: Simultaneous spatial temporal focusing (SSTF) is used to deliver microjoule femtosecond pulses with low numerical aperture geometries (<0.05 NA) with characteristics that are significantly improved compared to standard focusing paradigms.Nonlinear effects that would normally result in focal plane shifts and focal spot distortion are mitigated when SSTF is employed.As a result, it is shown that SSTF will enable surgical implementations that are presently inhibited.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Colorado School of Mines, 1523 Illinois Street, Golden, CO 80401, USA.

ABSTRACT
Simultaneous spatial temporal focusing (SSTF) is used to deliver microjoule femtosecond pulses with low numerical aperture geometries (<0.05 NA) with characteristics that are significantly improved compared to standard focusing paradigms. Nonlinear effects that would normally result in focal plane shifts and focal spot distortion are mitigated when SSTF is employed. As a result, it is shown that SSTF will enable surgical implementations that are presently inhibited.

No MeSH data available.


Related in: MedlinePlus

Histological tissue slice of porcine lens. SSTF was employed and the sample was translated at a speed of 10.8 mm/s through focus.
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Related In: Results  -  Collection


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g010: Histological tissue slice of porcine lens. SSTF was employed and the sample was translated at a speed of 10.8 mm/s through focus.

Mentions: Fluence as a function of axial position. Blue – is the fluence for the standard focus. Black - is the fluence for the SSTF focus. Red – is the measured ablation threshold (from [14]) for a 100 fs pulse. The light red fill illustrates the portion of the SSTF focus that is above the ablation threshold and the region were damage could be expected. The light blue fill illustrates the region of the SSTF focus below the ablation threshold. Note that the standard focus (blue contour) is above the ablation threshold (red contour) for the entire region depicted in the plot.


Simultaneous spatial and temporal focusing for tissue ablation.

Block E, Greco M, Vitek D, Masihzadeh O, Ammar DA, Kahook MY, Mandava N, Durfee C, Squier J - Biomed Opt Express (2013)

Histological tissue slice of porcine lens. SSTF was employed and the sample was translated at a speed of 10.8 mm/s through focus.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3675863&req=5

g010: Histological tissue slice of porcine lens. SSTF was employed and the sample was translated at a speed of 10.8 mm/s through focus.
Mentions: Fluence as a function of axial position. Blue – is the fluence for the standard focus. Black - is the fluence for the SSTF focus. Red – is the measured ablation threshold (from [14]) for a 100 fs pulse. The light red fill illustrates the portion of the SSTF focus that is above the ablation threshold and the region were damage could be expected. The light blue fill illustrates the region of the SSTF focus below the ablation threshold. Note that the standard focus (blue contour) is above the ablation threshold (red contour) for the entire region depicted in the plot.

Bottom Line: Simultaneous spatial temporal focusing (SSTF) is used to deliver microjoule femtosecond pulses with low numerical aperture geometries (<0.05 NA) with characteristics that are significantly improved compared to standard focusing paradigms.Nonlinear effects that would normally result in focal plane shifts and focal spot distortion are mitigated when SSTF is employed.As a result, it is shown that SSTF will enable surgical implementations that are presently inhibited.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Colorado School of Mines, 1523 Illinois Street, Golden, CO 80401, USA.

ABSTRACT
Simultaneous spatial temporal focusing (SSTF) is used to deliver microjoule femtosecond pulses with low numerical aperture geometries (<0.05 NA) with characteristics that are significantly improved compared to standard focusing paradigms. Nonlinear effects that would normally result in focal plane shifts and focal spot distortion are mitigated when SSTF is employed. As a result, it is shown that SSTF will enable surgical implementations that are presently inhibited.

No MeSH data available.


Related in: MedlinePlus