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Near-Infrared Fluorescent Materials for Sensing of Biological Targets

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ABSTRACT

Near-infrared fluorescent (NIRF) materials are promising labeling reagents for sensitive determination and imaging of biological targets. In the near-infrared region biological samples have low background fluorescence signals, providing high signal to noise ratio. Meanwhile, near-infrared radiation can penetrate into sample matrices deeply due to low light scattering. Thus, in vivo and in vitro imaging of biological samples can be achieved by employing the NIRF probes. To take full advantage of NIRF materials in the biological and biomedical field, one of the key issues is to develop intense and biocompatible NIRF probes. In this review, a number of NIRF materials are discussed including traditional NIRF dye molecules, newly developed NIRF quantum dots and single-walled carbon nanotubes, as well as rare earth metal compounds. The use of some NIRF materials in various nanostructures is illustrated. The enhancement of NIRF using metal nanostructures is covered as well. The fluorescence mechanism and bioapplications of each type of the NIRF materials are discussed in details.

No MeSH data available.


Expected structure of the Ln(hfth)3phen–M41 (Ln = Er, Nd, Yb, Sm) and Pr(tfnb)3phen–M41 mesoporous materials. hfth = 4,4,5,5,6,6,6-heptafluoro-1-(2-thienyl)hexane-1,3-dionate; tfnb = 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedionate. Reprinted with permission from [69]. Copyright (2007) Elsevier.
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f9-sensors-08-03082: Expected structure of the Ln(hfth)3phen–M41 (Ln = Er, Nd, Yb, Sm) and Pr(tfnb)3phen–M41 mesoporous materials. hfth = 4,4,5,5,6,6,6-heptafluoro-1-(2-thienyl)hexane-1,3-dionate; tfnb = 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedionate. Reprinted with permission from [69]. Copyright (2007) Elsevier.

Mentions: In addition to silica nanospheres and sol-gel matrix, some materials with nano-sized pores can be used to incorporate the NIRF materials, such as mesoporous silicate-based materials. Sun et al. [69] covalently immobilized ternary lanthanide (Er3+, Nd3+, Yb3+, Sm3+, Pr3+) complexes to the phen functionalized mesoporous MCM-41 (Figure 9). The ligands around the lanthanide ions (including hfth/tfnb and phen ligands) could efficiently transfer the absorbed energy to the lanthanide ions. NIRF from lanthanide ions (Er3+, Nd3+, Yb3+, Sm3+, Pr3+) have been obtained in the region of 1300-1600 nm. The highly ordered hexagonal channel structures and uniform tunable pore sizes of MCM-41 mesoporous material open a new field to orderly composite materials for lasers and optical amplification.


Near-Infrared Fluorescent Materials for Sensing of Biological Targets
Expected structure of the Ln(hfth)3phen–M41 (Ln = Er, Nd, Yb, Sm) and Pr(tfnb)3phen–M41 mesoporous materials. hfth = 4,4,5,5,6,6,6-heptafluoro-1-(2-thienyl)hexane-1,3-dionate; tfnb = 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedionate. Reprinted with permission from [69]. Copyright (2007) Elsevier.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3675533&req=5

f9-sensors-08-03082: Expected structure of the Ln(hfth)3phen–M41 (Ln = Er, Nd, Yb, Sm) and Pr(tfnb)3phen–M41 mesoporous materials. hfth = 4,4,5,5,6,6,6-heptafluoro-1-(2-thienyl)hexane-1,3-dionate; tfnb = 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedionate. Reprinted with permission from [69]. Copyright (2007) Elsevier.
Mentions: In addition to silica nanospheres and sol-gel matrix, some materials with nano-sized pores can be used to incorporate the NIRF materials, such as mesoporous silicate-based materials. Sun et al. [69] covalently immobilized ternary lanthanide (Er3+, Nd3+, Yb3+, Sm3+, Pr3+) complexes to the phen functionalized mesoporous MCM-41 (Figure 9). The ligands around the lanthanide ions (including hfth/tfnb and phen ligands) could efficiently transfer the absorbed energy to the lanthanide ions. NIRF from lanthanide ions (Er3+, Nd3+, Yb3+, Sm3+, Pr3+) have been obtained in the region of 1300-1600 nm. The highly ordered hexagonal channel structures and uniform tunable pore sizes of MCM-41 mesoporous material open a new field to orderly composite materials for lasers and optical amplification.

View Article: PubMed Central

ABSTRACT

Near-infrared fluorescent (NIRF) materials are promising labeling reagents for sensitive determination and imaging of biological targets. In the near-infrared region biological samples have low background fluorescence signals, providing high signal to noise ratio. Meanwhile, near-infrared radiation can penetrate into sample matrices deeply due to low light scattering. Thus, in vivo and in vitro imaging of biological samples can be achieved by employing the NIRF probes. To take full advantage of NIRF materials in the biological and biomedical field, one of the key issues is to develop intense and biocompatible NIRF probes. In this review, a number of NIRF materials are discussed including traditional NIRF dye molecules, newly developed NIRF quantum dots and single-walled carbon nanotubes, as well as rare earth metal compounds. The use of some NIRF materials in various nanostructures is illustrated. The enhancement of NIRF using metal nanostructures is covered as well. The fluorescence mechanism and bioapplications of each type of the NIRF materials are discussed in details.

No MeSH data available.