Limits...
Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses.

Han J, Niu F, Jin M, Wang L, Liu J, Zhang P, Xie B, Wu X, Wen D, Ji L, Liu G, Yang Z, Zhang C, Zhou D, Leng Q, Lan K - Emerg Microbes Infect (2013)

Bottom Line: The patient had been exposed to poultry before disease onset.Phylogenetic analyses of hemagglutinin and neuraminidase genes showed a close genetic relationship between viruses from the patient and from poultry booths where he had visited, indicating that the patient may have been exposed from the infected poultry.Furthermore, we found five novel H7N9 virus-specific sequence variations in receptor-binding site of hemagglutinin, which may be associated with the acquisition of the ability to infect humans.

View Article: PubMed Central - PubMed

Affiliation: Huzhou Center for Disease Control and Prevention , Huzhou 313000, Zhejiang, China.

ABSTRACT
Recently, a novel H7N9 avian influenza A virus has led to a human influenza outbreak in China. Here we report a 64-year old man with possible history of chronic bronchitis died from the H7N9 infection in Huzhou City, Zhejiang Province in Eastern China. The patient had been exposed to poultry before disease onset. Phylogenetic analyses of hemagglutinin and neuraminidase genes showed a close genetic relationship between viruses from the patient and from poultry booths where he had visited, indicating that the patient may have been exposed from the infected poultry. Two poultry venders and close contacts of the patient were negative for H7N9, suggesting that there are some unknown mechanisms to prevent them from being infected by the novel H7N9 virus. Furthermore, we found five novel H7N9 virus-specific sequence variations in receptor-binding site of hemagglutinin, which may be associated with the acquisition of the ability to infect humans.

No MeSH data available.


Related in: MedlinePlus

Sequence comparison of RBS in HA between the novel H7N9 and avian H7N3. The red stars indicate the H7N9 virus-specific variants. The red triangles indicate variants occurring in all H7N9 viruses except A/Shanghai/1/2013.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3675404&req=5

fig3: Sequence comparison of RBS in HA between the novel H7N9 and avian H7N3. The red stars indicate the H7N9 virus-specific variants. The red triangles indicate variants occurring in all H7N9 viruses except A/Shanghai/1/2013.

Mentions: Comparison of amino acid sequences of the receptor-binding site (RBS) (amino acids 105–319) in HA showed that there are five variants K181R, D183S/N, I188V, I211V and V298I occurring between H7N3 and H7N9 (Figure 3). In addition, three additional variants G195V, Q235L/I and D285N were found in all the novel H7N9 strains except A/Shanghai/1/2013, which has identical amino acids to H7N3 virus in the three sites.


Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses.

Han J, Niu F, Jin M, Wang L, Liu J, Zhang P, Xie B, Wu X, Wen D, Ji L, Liu G, Yang Z, Zhang C, Zhou D, Leng Q, Lan K - Emerg Microbes Infect (2013)

Sequence comparison of RBS in HA between the novel H7N9 and avian H7N3. The red stars indicate the H7N9 virus-specific variants. The red triangles indicate variants occurring in all H7N9 viruses except A/Shanghai/1/2013.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3675404&req=5

fig3: Sequence comparison of RBS in HA between the novel H7N9 and avian H7N3. The red stars indicate the H7N9 virus-specific variants. The red triangles indicate variants occurring in all H7N9 viruses except A/Shanghai/1/2013.
Mentions: Comparison of amino acid sequences of the receptor-binding site (RBS) (amino acids 105–319) in HA showed that there are five variants K181R, D183S/N, I188V, I211V and V298I occurring between H7N3 and H7N9 (Figure 3). In addition, three additional variants G195V, Q235L/I and D285N were found in all the novel H7N9 strains except A/Shanghai/1/2013, which has identical amino acids to H7N3 virus in the three sites.

Bottom Line: The patient had been exposed to poultry before disease onset.Phylogenetic analyses of hemagglutinin and neuraminidase genes showed a close genetic relationship between viruses from the patient and from poultry booths where he had visited, indicating that the patient may have been exposed from the infected poultry.Furthermore, we found five novel H7N9 virus-specific sequence variations in receptor-binding site of hemagglutinin, which may be associated with the acquisition of the ability to infect humans.

View Article: PubMed Central - PubMed

Affiliation: Huzhou Center for Disease Control and Prevention , Huzhou 313000, Zhejiang, China.

ABSTRACT
Recently, a novel H7N9 avian influenza A virus has led to a human influenza outbreak in China. Here we report a 64-year old man with possible history of chronic bronchitis died from the H7N9 infection in Huzhou City, Zhejiang Province in Eastern China. The patient had been exposed to poultry before disease onset. Phylogenetic analyses of hemagglutinin and neuraminidase genes showed a close genetic relationship between viruses from the patient and from poultry booths where he had visited, indicating that the patient may have been exposed from the infected poultry. Two poultry venders and close contacts of the patient were negative for H7N9, suggesting that there are some unknown mechanisms to prevent them from being infected by the novel H7N9 virus. Furthermore, we found five novel H7N9 virus-specific sequence variations in receptor-binding site of hemagglutinin, which may be associated with the acquisition of the ability to infect humans.

No MeSH data available.


Related in: MedlinePlus