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Seeking a bridge between language and motor cortices: a PPI study.

Maieron M, Marin D, Fabbro F, Skrap M - Front Hum Neurosci (2013)

Bottom Line: A lack of significant changes in the functional coupling between the left M1 cortex and functional nodes of the linguistic network during the verb generation task was found for all the groups.In addition, we found that the ability to perform an action verb naming task was not related to a damaged M1.We will discuss how these findings indicate that action words do not automatically activate the M1 cortex; we suggest rather that its enrolment could be related to other not strictly linguistic processing.

View Article: PubMed Central - PubMed

Affiliation: Fisica Medica, Azienda Ospedaliero Universitaria Santa Maria Della Misericordia Udine, Italy.

ABSTRACT
The relation between the sensorimotor cortex and the language network has been widely discussed but still remains controversial. Two independent theories compete to explain how this area is involved during action-related verbs processing. The embodied view assumes that action word representations activate sensorimotor representations which are accessed when an action word is processed or when an action is observed. The abstract hypothesis states that the mental representations of words are abstract and independent of the objects' sensorimotor properties they refer to. We combined neuropsychological and fMRI-PPI connectivity data, to address action-related verbs processing in neurosurgical patients with lesions involving (N = 5) or sparing (N = 5) the primary motor cortex and healthy controls (N = 12). A lack of significant changes in the functional coupling between the left M1 cortex and functional nodes of the linguistic network during the verb generation task was found for all the groups. In addition, we found that the ability to perform an action verb naming task was not related to a damaged M1. These data showed that there was not a task-specific functional interaction active between M1 and the inferior frontal gyrus. We will discuss how these findings indicate that action words do not automatically activate the M1 cortex; we suggest rather that its enrolment could be related to other not strictly linguistic processing.

No MeSH data available.


(A) Activation elicited by the verb generation task vs. rest (p < 0.05 cluster corrected (Z > 2.3) for healthy controls (upper row), for patients with lesions involving M1 (M1−, middle row) and for patients with lesions sparing M1 (M1+, lower row). (B) The image shows the activation maps generated by the PPI analysis. Brain regions showing significant increases of connectivity to the left Broca's area during verb generation task for healthy controls and for M1− are shown. For M1+ PPI analysis didn't find any area with a significant activation. (C) Overlapping of the seed regions (Broca's and M1 area) on a rendered 3D template.
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Figure 2: (A) Activation elicited by the verb generation task vs. rest (p < 0.05 cluster corrected (Z > 2.3) for healthy controls (upper row), for patients with lesions involving M1 (M1−, middle row) and for patients with lesions sparing M1 (M1+, lower row). (B) The image shows the activation maps generated by the PPI analysis. Brain regions showing significant increases of connectivity to the left Broca's area during verb generation task for healthy controls and for M1− are shown. For M1+ PPI analysis didn't find any area with a significant activation. (C) Overlapping of the seed regions (Broca's and M1 area) on a rendered 3D template.

Mentions: The verb generation task (verb generation > rest) triggered a cluster of increased activity in a set of brain regions typically found in language-related tasks, including: bilaterally in the occipital lobe, bilaterally in the hippocampus, in the temporal inferior cortex, the left precentralgyrus, the SMA, and the left insula (Table 4, Figure 2A)


Seeking a bridge between language and motor cortices: a PPI study.

Maieron M, Marin D, Fabbro F, Skrap M - Front Hum Neurosci (2013)

(A) Activation elicited by the verb generation task vs. rest (p < 0.05 cluster corrected (Z > 2.3) for healthy controls (upper row), for patients with lesions involving M1 (M1−, middle row) and for patients with lesions sparing M1 (M1+, lower row). (B) The image shows the activation maps generated by the PPI analysis. Brain regions showing significant increases of connectivity to the left Broca's area during verb generation task for healthy controls and for M1− are shown. For M1+ PPI analysis didn't find any area with a significant activation. (C) Overlapping of the seed regions (Broca's and M1 area) on a rendered 3D template.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3675382&req=5

Figure 2: (A) Activation elicited by the verb generation task vs. rest (p < 0.05 cluster corrected (Z > 2.3) for healthy controls (upper row), for patients with lesions involving M1 (M1−, middle row) and for patients with lesions sparing M1 (M1+, lower row). (B) The image shows the activation maps generated by the PPI analysis. Brain regions showing significant increases of connectivity to the left Broca's area during verb generation task for healthy controls and for M1− are shown. For M1+ PPI analysis didn't find any area with a significant activation. (C) Overlapping of the seed regions (Broca's and M1 area) on a rendered 3D template.
Mentions: The verb generation task (verb generation > rest) triggered a cluster of increased activity in a set of brain regions typically found in language-related tasks, including: bilaterally in the occipital lobe, bilaterally in the hippocampus, in the temporal inferior cortex, the left precentralgyrus, the SMA, and the left insula (Table 4, Figure 2A)

Bottom Line: A lack of significant changes in the functional coupling between the left M1 cortex and functional nodes of the linguistic network during the verb generation task was found for all the groups.In addition, we found that the ability to perform an action verb naming task was not related to a damaged M1.We will discuss how these findings indicate that action words do not automatically activate the M1 cortex; we suggest rather that its enrolment could be related to other not strictly linguistic processing.

View Article: PubMed Central - PubMed

Affiliation: Fisica Medica, Azienda Ospedaliero Universitaria Santa Maria Della Misericordia Udine, Italy.

ABSTRACT
The relation between the sensorimotor cortex and the language network has been widely discussed but still remains controversial. Two independent theories compete to explain how this area is involved during action-related verbs processing. The embodied view assumes that action word representations activate sensorimotor representations which are accessed when an action word is processed or when an action is observed. The abstract hypothesis states that the mental representations of words are abstract and independent of the objects' sensorimotor properties they refer to. We combined neuropsychological and fMRI-PPI connectivity data, to address action-related verbs processing in neurosurgical patients with lesions involving (N = 5) or sparing (N = 5) the primary motor cortex and healthy controls (N = 12). A lack of significant changes in the functional coupling between the left M1 cortex and functional nodes of the linguistic network during the verb generation task was found for all the groups. In addition, we found that the ability to perform an action verb naming task was not related to a damaged M1. These data showed that there was not a task-specific functional interaction active between M1 and the inferior frontal gyrus. We will discuss how these findings indicate that action words do not automatically activate the M1 cortex; we suggest rather that its enrolment could be related to other not strictly linguistic processing.

No MeSH data available.