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Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.

Li BQ, Niu B, Chen L, Wei ZJ, Huang T, Jiang M, Lu J, Zheng MY, Kong XY, Cai YD - PLoS ONE (2013)

Bottom Line: In recent years, the emergence of numerous useful information of protein-protein interactions (PPI) in the HIV life cycle and related inhibitors makes PPI a new way for antiviral drug intervention.In this study, we identified 26 core human proteins involved in PPI between HIV-1 and host, that have great potential for HIV therapy.In addition, 280 chemicals that interact with three HIV drugs targeting human proteins can also interact with these 26 core proteins.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China.

ABSTRACT
Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from drug resistance after a period of treatment and serious side effects. In recent years, the emergence of numerous useful information of protein-protein interactions (PPI) in the HIV life cycle and related inhibitors makes PPI a new way for antiviral drug intervention. In this study, we identified 26 core human proteins involved in PPI between HIV-1 and host, that have great potential for HIV therapy. In addition, 280 chemicals that interact with three HIV drugs targeting human proteins can also interact with these 26 core proteins. All these indicate that our method as presented in this paper is quite promising. The method may become a useful tool, or at least plays a complementary role to the existing method, for identifying novel anti-HIV drugs.

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Related in: MedlinePlus

The number of interactive chemicals among 280 chemicals for each of the 26 core proteins.
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pone-0065207-g001: The number of interactive chemicals among 280 chemicals for each of the 26 core proteins.

Mentions: For each of the three HIV related drugs, its interactive chemicals in STITCH can be found. After collecting these chemicals and combining with the three drugs, we obtained 280 chemicals (Additional File S3). For each of 26 proteins, we can count the number of the interactive chemicals among these 280 chemicals. Figure 1 shows the number of interactive chemicals among 280 chemicals. From Fig. 1, we can see that the number of chemicals related to ENSP00000011653 (CD4) is the largest, followed by that of ENSP00000292303 (CCR5). The chemicals related to each of the 26 proteins were ranked according to their interaction score (see Additional File S4).


Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.

Li BQ, Niu B, Chen L, Wei ZJ, Huang T, Jiang M, Lu J, Zheng MY, Kong XY, Cai YD - PLoS ONE (2013)

The number of interactive chemicals among 280 chemicals for each of the 26 core proteins.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3675210&req=5

pone-0065207-g001: The number of interactive chemicals among 280 chemicals for each of the 26 core proteins.
Mentions: For each of the three HIV related drugs, its interactive chemicals in STITCH can be found. After collecting these chemicals and combining with the three drugs, we obtained 280 chemicals (Additional File S3). For each of 26 proteins, we can count the number of the interactive chemicals among these 280 chemicals. Figure 1 shows the number of interactive chemicals among 280 chemicals. From Fig. 1, we can see that the number of chemicals related to ENSP00000011653 (CD4) is the largest, followed by that of ENSP00000292303 (CCR5). The chemicals related to each of the 26 proteins were ranked according to their interaction score (see Additional File S4).

Bottom Line: In recent years, the emergence of numerous useful information of protein-protein interactions (PPI) in the HIV life cycle and related inhibitors makes PPI a new way for antiviral drug intervention.In this study, we identified 26 core human proteins involved in PPI between HIV-1 and host, that have great potential for HIV therapy.In addition, 280 chemicals that interact with three HIV drugs targeting human proteins can also interact with these 26 core proteins.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China.

ABSTRACT
Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from drug resistance after a period of treatment and serious side effects. In recent years, the emergence of numerous useful information of protein-protein interactions (PPI) in the HIV life cycle and related inhibitors makes PPI a new way for antiviral drug intervention. In this study, we identified 26 core human proteins involved in PPI between HIV-1 and host, that have great potential for HIV therapy. In addition, 280 chemicals that interact with three HIV drugs targeting human proteins can also interact with these 26 core proteins. All these indicate that our method as presented in this paper is quite promising. The method may become a useful tool, or at least plays a complementary role to the existing method, for identifying novel anti-HIV drugs.

Show MeSH
Related in: MedlinePlus