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Magnetoencephalographic study on forward suppression by ipsilateral, contralateral, and binaural maskers.

Nishimura T, Uratani Y, Okayasu T, Nakagawa S, Hosoi H - PLoS ONE (2013)

Bottom Line: Regarding the responses to the maskers without signal, the N1m amplitude evoked by the left and binaural maskers was significantly larger than that evoked by the right masker for the left-strong and left-right-balanced conditions.No significant difference was observed for the right-strong condition.For left-right-balanced condition, the subsequent N1m amplitude decreased in the presence of the right, binaural, and left maskers in that order.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head and Neck surgery, Nara Medical University, Nara, Japan. t-nishim@naramed-u.ac.jp

ABSTRACT
When two tones are presented in a short time interval, the response to the second tone is suppressed. This phenomenon is referred to as forward suppression. To address the effect of the masker laterality on forward suppression, magnetoencephalographic responses were investigated for eight subjects with normal hearing when the preceding maskers were presented ipsilaterally, contralaterally, and binaurally. We employed three masker intensity conditions: the ipsilateral-strong, left-right-balanced, and contralateral-strong conditions. Regarding the responses to the maskers without signal, the N1m amplitude evoked by the left and binaural maskers was significantly larger than that evoked by the right masker for the left-strong and left-right-balanced conditions. No significant difference was observed for the right-strong condition. Regarding the subsequent N1m amplitudes, they were attenuated by the presence of the left, binaural, and right maskers for all conditions. For the left- and right-strong conditions, the subsequent N1m amplitude in the presence of the left masker was smaller than those of the binaural and right maskers. No difference was observed between the binaural and right masker presentation. For left-right-balanced condition, the subsequent N1m amplitude decreased in the presence of the right, binaural, and left maskers in that order. If the preceding activity reflected the ability to suppress the subsequent activity, the forward suppression by the left masker would be superior to that by the right masker for the left-strong and left-right-balanced conditions. Furthermore, the forward suppression by the binaural masker would be expected to be superior to that by the left masker owing to additional afferent activity from the right ear. Thus, the current results suggest that the forward suppression by ipsilateral maskers is superior to that by contralateral maskers although both maskers evoked the N1m amplitudes to the same degree. Additional masker at the contralateral ear can attenuate the forward suppression by the ipsilateral masker.

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Related in: MedlinePlus

Square means of the responses at the channel where the maximum N1m amplitude was observed in a subject.The N1m amplitudes evoked by the signal decreased in the presence of the maskers. Solid and dashed vertical bars indicate the onset of masker and signal, respectively.
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pone-0066225-g003: Square means of the responses at the channel where the maximum N1m amplitude was observed in a subject.The N1m amplitudes evoked by the signal decreased in the presence of the maskers. Solid and dashed vertical bars indicate the onset of masker and signal, respectively.

Mentions: Figure 3 shows the square means of the responses at the channel where the maximum N1m amplitude was observed for a subject. The subsequent N1m amplitudes that were the responses to the signal were suppressed in the presence of the maskers for any conditions. Figure 4(a) shows the mean subsequent N1m amplitude before subtracting the responses to the maskers. One-way ANOVAs revealed a statistically significant effect for masker condition for all three conditions: the left-strong (F[3,21] = 65.811, p<0.01), left-right-balanced (F[3,21] = 52.8, p<0.01), and right-strong conditions (F[3,21] = 33.784, p<0.01). The subsequent N1m amplitudes were significantly attenuated by the presence of the left, binaural, and right maskers for all conditions (p<0.05). For the left- and right-strong conditions, the subsequent N1m amplitude in the presence of the left masker was significantly smaller than those of the binaural and right maskers (p<0.05). No difference was observed between the binaural and right masker presentation. For left-right-balanced condition, the subsequent N1m amplitude significantly decreased in the presence of the right, binaural, and left maskers in that order (p<0.05).


Magnetoencephalographic study on forward suppression by ipsilateral, contralateral, and binaural maskers.

Nishimura T, Uratani Y, Okayasu T, Nakagawa S, Hosoi H - PLoS ONE (2013)

Square means of the responses at the channel where the maximum N1m amplitude was observed in a subject.The N1m amplitudes evoked by the signal decreased in the presence of the maskers. Solid and dashed vertical bars indicate the onset of masker and signal, respectively.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3675151&req=5

pone-0066225-g003: Square means of the responses at the channel where the maximum N1m amplitude was observed in a subject.The N1m amplitudes evoked by the signal decreased in the presence of the maskers. Solid and dashed vertical bars indicate the onset of masker and signal, respectively.
Mentions: Figure 3 shows the square means of the responses at the channel where the maximum N1m amplitude was observed for a subject. The subsequent N1m amplitudes that were the responses to the signal were suppressed in the presence of the maskers for any conditions. Figure 4(a) shows the mean subsequent N1m amplitude before subtracting the responses to the maskers. One-way ANOVAs revealed a statistically significant effect for masker condition for all three conditions: the left-strong (F[3,21] = 65.811, p<0.01), left-right-balanced (F[3,21] = 52.8, p<0.01), and right-strong conditions (F[3,21] = 33.784, p<0.01). The subsequent N1m amplitudes were significantly attenuated by the presence of the left, binaural, and right maskers for all conditions (p<0.05). For the left- and right-strong conditions, the subsequent N1m amplitude in the presence of the left masker was significantly smaller than those of the binaural and right maskers (p<0.05). No difference was observed between the binaural and right masker presentation. For left-right-balanced condition, the subsequent N1m amplitude significantly decreased in the presence of the right, binaural, and left maskers in that order (p<0.05).

Bottom Line: Regarding the responses to the maskers without signal, the N1m amplitude evoked by the left and binaural maskers was significantly larger than that evoked by the right masker for the left-strong and left-right-balanced conditions.No significant difference was observed for the right-strong condition.For left-right-balanced condition, the subsequent N1m amplitude decreased in the presence of the right, binaural, and left maskers in that order.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head and Neck surgery, Nara Medical University, Nara, Japan. t-nishim@naramed-u.ac.jp

ABSTRACT
When two tones are presented in a short time interval, the response to the second tone is suppressed. This phenomenon is referred to as forward suppression. To address the effect of the masker laterality on forward suppression, magnetoencephalographic responses were investigated for eight subjects with normal hearing when the preceding maskers were presented ipsilaterally, contralaterally, and binaurally. We employed three masker intensity conditions: the ipsilateral-strong, left-right-balanced, and contralateral-strong conditions. Regarding the responses to the maskers without signal, the N1m amplitude evoked by the left and binaural maskers was significantly larger than that evoked by the right masker for the left-strong and left-right-balanced conditions. No significant difference was observed for the right-strong condition. Regarding the subsequent N1m amplitudes, they were attenuated by the presence of the left, binaural, and right maskers for all conditions. For the left- and right-strong conditions, the subsequent N1m amplitude in the presence of the left masker was smaller than those of the binaural and right maskers. No difference was observed between the binaural and right masker presentation. For left-right-balanced condition, the subsequent N1m amplitude decreased in the presence of the right, binaural, and left maskers in that order. If the preceding activity reflected the ability to suppress the subsequent activity, the forward suppression by the left masker would be superior to that by the right masker for the left-strong and left-right-balanced conditions. Furthermore, the forward suppression by the binaural masker would be expected to be superior to that by the left masker owing to additional afferent activity from the right ear. Thus, the current results suggest that the forward suppression by ipsilateral maskers is superior to that by contralateral maskers although both maskers evoked the N1m amplitudes to the same degree. Additional masker at the contralateral ear can attenuate the forward suppression by the ipsilateral masker.

Show MeSH
Related in: MedlinePlus