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Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis.

Huang C, Xu Y, Li X, Wang W - Mol. Vis. (2013)

Bottom Line: For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35).For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31).The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

ABSTRACT

Purpose: In the present work, the aim was to systematically review all studies about the association of vascular endothelial growth factor A (VEGF-A) polymorphisms with age-related macular degeneration (AMD) and to perform a meta-analysis.

Methods: Relevant studies were searched using PubMed, Embase, Wanfang (Chinese), VIP (Chinese), and the Chinese National Knowledge Infrastructure databases up to October, 2011. A meta-analysis was conducted using Stata software, version 11.0.

Results: A total of nine studies with 2,281 AMD cases and 2,820 controls met our eligibility criteria, and meta-analyses of four polymorphisms of the VEGF-A gene (rs1413711, rs833061, rs2010963, and rs3025039) were performed. This meta-analysis revealed moderate evidence supporting an association between the VEGF-A polymorphisms and AMD. For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35). For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31). No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.

Conclusions: The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

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Related in: MedlinePlus

The VEGF-A polymorphisms used in eligible studies. Ex, exon; IVS, intervening sequence.
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f2: The VEGF-A polymorphisms used in eligible studies. Ex, exon; IVS, intervening sequence.

Mentions: These studies focused on 20 identified polymorphisms of the VEGF-A gene (Figure 2): rs699947 and rs833061 in the promoter region, rs2010963 and rs25648 in the 5′ UTR, rs1413711 in the intron 1, rs833068, rs833069, rs833070, rs3024994, rs735286, rs2146323, and rs3024997 in the intron 2, rs3025007 in the intron 5, rs3025021 and rs3025024 in the intron 6, rs3025030, rs3025033, and rs3025035 in the intron 7, rs3025039 in the exon 8, and rs10434 in the 3′ UTR. Data reported in at least three published studies were available for four VEGF-A polymorphisms (rs1413711, rs833061, rs2010963, and rs3025039). The lists of genotypes and allelic frequencies of these four VEGF-A polymorphisms in the eligible studies are provided in Table 2. A study [16] investigating the rs2010963 polymorphism significantly deviated from HWE (p<0.05).


Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis.

Huang C, Xu Y, Li X, Wang W - Mol. Vis. (2013)

The VEGF-A polymorphisms used in eligible studies. Ex, exon; IVS, intervening sequence.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3675058&req=5

f2: The VEGF-A polymorphisms used in eligible studies. Ex, exon; IVS, intervening sequence.
Mentions: These studies focused on 20 identified polymorphisms of the VEGF-A gene (Figure 2): rs699947 and rs833061 in the promoter region, rs2010963 and rs25648 in the 5′ UTR, rs1413711 in the intron 1, rs833068, rs833069, rs833070, rs3024994, rs735286, rs2146323, and rs3024997 in the intron 2, rs3025007 in the intron 5, rs3025021 and rs3025024 in the intron 6, rs3025030, rs3025033, and rs3025035 in the intron 7, rs3025039 in the exon 8, and rs10434 in the 3′ UTR. Data reported in at least three published studies were available for four VEGF-A polymorphisms (rs1413711, rs833061, rs2010963, and rs3025039). The lists of genotypes and allelic frequencies of these four VEGF-A polymorphisms in the eligible studies are provided in Table 2. A study [16] investigating the rs2010963 polymorphism significantly deviated from HWE (p<0.05).

Bottom Line: For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35).For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31).The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

ABSTRACT

Purpose: In the present work, the aim was to systematically review all studies about the association of vascular endothelial growth factor A (VEGF-A) polymorphisms with age-related macular degeneration (AMD) and to perform a meta-analysis.

Methods: Relevant studies were searched using PubMed, Embase, Wanfang (Chinese), VIP (Chinese), and the Chinese National Knowledge Infrastructure databases up to October, 2011. A meta-analysis was conducted using Stata software, version 11.0.

Results: A total of nine studies with 2,281 AMD cases and 2,820 controls met our eligibility criteria, and meta-analyses of four polymorphisms of the VEGF-A gene (rs1413711, rs833061, rs2010963, and rs3025039) were performed. This meta-analysis revealed moderate evidence supporting an association between the VEGF-A polymorphisms and AMD. For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35). For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31). No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.

Conclusions: The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

Show MeSH
Related in: MedlinePlus