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Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis.

Huang C, Xu Y, Li X, Wang W - Mol. Vis. (2013)

Bottom Line: For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35).For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31).The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

ABSTRACT

Purpose: In the present work, the aim was to systematically review all studies about the association of vascular endothelial growth factor A (VEGF-A) polymorphisms with age-related macular degeneration (AMD) and to perform a meta-analysis.

Methods: Relevant studies were searched using PubMed, Embase, Wanfang (Chinese), VIP (Chinese), and the Chinese National Knowledge Infrastructure databases up to October, 2011. A meta-analysis was conducted using Stata software, version 11.0.

Results: A total of nine studies with 2,281 AMD cases and 2,820 controls met our eligibility criteria, and meta-analyses of four polymorphisms of the VEGF-A gene (rs1413711, rs833061, rs2010963, and rs3025039) were performed. This meta-analysis revealed moderate evidence supporting an association between the VEGF-A polymorphisms and AMD. For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35). For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31). No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.

Conclusions: The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

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Related in: MedlinePlus

Flow for identifying and selecting studies in this meta-analysis.
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f1: Flow for identifying and selecting studies in this meta-analysis.

Mentions: Eighty potentially relevant papers were retrieved (38 in PubMed, 42 in Embase, 0 in Wanfang, 0 in VIP, and 0 in CNKI). Sixty-seven studies were subjected to a full-text review and excluded according to the selection criteria stated above. Thirteen studies were identified that examined the association between VEGF-A polymorphisms and AMD risk [13-16,23-31] and four of these studies were excluded for insufficient data [14,29-31]. As summarized in Table 1 and Figure 1, data were available from a total of nine studies [13,15,16,23-28], with 2,281 AMD patients and 2,820 control subjects in total. The definitions of AMD patients and controls in these studies were based on clinical ophthalmic examinations and various grading systems, such as the Clinical Age-Related Maculopathy Staging (CARMS) system [24], the International Age-Related Maculopathy (ARM) Epidemiologic Study [16,26], the Age-Related Eye Disease Study (AREDS) [27], and others [13,15,23,25,28] (Appendix 1). Controls were defined as those subjects having no clinical evidence of AMD, without detectable drusen or pigmentary abnormalities, or without drusen of more than 63 μm in both eyes.


Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis.

Huang C, Xu Y, Li X, Wang W - Mol. Vis. (2013)

Flow for identifying and selecting studies in this meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3675058&req=5

f1: Flow for identifying and selecting studies in this meta-analysis.
Mentions: Eighty potentially relevant papers were retrieved (38 in PubMed, 42 in Embase, 0 in Wanfang, 0 in VIP, and 0 in CNKI). Sixty-seven studies were subjected to a full-text review and excluded according to the selection criteria stated above. Thirteen studies were identified that examined the association between VEGF-A polymorphisms and AMD risk [13-16,23-31] and four of these studies were excluded for insufficient data [14,29-31]. As summarized in Table 1 and Figure 1, data were available from a total of nine studies [13,15,16,23-28], with 2,281 AMD patients and 2,820 control subjects in total. The definitions of AMD patients and controls in these studies were based on clinical ophthalmic examinations and various grading systems, such as the Clinical Age-Related Maculopathy Staging (CARMS) system [24], the International Age-Related Maculopathy (ARM) Epidemiologic Study [16,26], the Age-Related Eye Disease Study (AREDS) [27], and others [13,15,23,25,28] (Appendix 1). Controls were defined as those subjects having no clinical evidence of AMD, without detectable drusen or pigmentary abnormalities, or without drusen of more than 63 μm in both eyes.

Bottom Line: For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35).For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31).The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

ABSTRACT

Purpose: In the present work, the aim was to systematically review all studies about the association of vascular endothelial growth factor A (VEGF-A) polymorphisms with age-related macular degeneration (AMD) and to perform a meta-analysis.

Methods: Relevant studies were searched using PubMed, Embase, Wanfang (Chinese), VIP (Chinese), and the Chinese National Knowledge Infrastructure databases up to October, 2011. A meta-analysis was conducted using Stata software, version 11.0.

Results: A total of nine studies with 2,281 AMD cases and 2,820 controls met our eligibility criteria, and meta-analyses of four polymorphisms of the VEGF-A gene (rs1413711, rs833061, rs2010963, and rs3025039) were performed. This meta-analysis revealed moderate evidence supporting an association between the VEGF-A polymorphisms and AMD. For rs1413711, the TT genotype was associated with an increased risk of overall AMD (TT versus CT model, odds ratio (OR) 1.74, 95% confidence interval (CI) 1.22-2.48) and of wet AMD (TT versus CT model, OR 1.82, 95% CI 1.22-2.71; TT versus (CC+CT) model, OR 1.63, 95% CI 1.13-2.35). For rs833061, the C allele (C allele versus T allele, OR 1.72, 95% CI 1.00-2.96) and CC genotype (CC versus TT model, OR 1.77, 95% CI 1.00-3.11) were the risk factors for overall AMD, while the C allele was also associated with an increased risk of wet AMD (C allele versus T allele, OR 1.54, 95% CI 1.03-2.31). No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.

Conclusions: The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.

Show MeSH
Related in: MedlinePlus