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Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.

Messé A, Caplain S, Pélégrini-Issac M, Blancho S, Lévy R, Aghakhani N, Montreuil M, Benali H, Lehéricy S - PLoS ONE (2013)

Bottom Line: Group-wise differences in functional brain networks were analyzed using graph theory measures.Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients.Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.

View Article: PubMed Central - PubMed

Affiliation: Inserm, UPMC Univ Paris 06, UMRS 678, Laboratoire d'Imagerie Fonctionnelle, Paris, France. Arnaud.Messe@imed.jussieu.fr

ABSTRACT
Post-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injury in patients with post-concussion syndrome using resting-state functional magnetic resonance imaging data. We investigated 17 injured patients with persistent post-concussion syndrome (under the DSM-IV criteria) at 6 months post-injury compared with 38 mild traumatic brain injury patients with no post-concussion syndrome and 34 healthy controls. All patients underwent magnetic resonance imaging examinations at the subacute (1-3 weeks) and late (6 months) phases after injury. Group-wise differences in functional brain networks were analyzed using graph theory measures. Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients. Mild traumatic brain injury patients with post-concussion syndrome had greater alterations than patients without post-concussion syndrome. In patients with post-concussion syndrome, changes specifically affected temporal and thalamic regions predominantly at the subacute stage and frontal regions at the late phase. Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.

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Brain regions with significant group differences in topological graph properties (k, El, En and bc) between mTBI patients and controls at p<0.05 (uncorrected).The node size indicates the number of topological properties with significant group differences. The nodal regions are located according to their centroid stereotaxic coordinates. Nodal color code for the average size effect, hot (resp. cold) colors represent increased (resp. decreased) properties.
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pone-0065470-g004: Brain regions with significant group differences in topological graph properties (k, El, En and bc) between mTBI patients and controls at p<0.05 (uncorrected).The node size indicates the number of topological properties with significant group differences. The nodal regions are located according to their centroid stereotaxic coordinates. Nodal color code for the average size effect, hot (resp. cold) colors represent increased (resp. decreased) properties.

Mentions: Patients presented more differences in topological properties than in connectivity measures. In PCS– patients compared with controls differences were mostly found at the late phase in the limbic system with an increase in properties (Figure 4). In PCS+ patients at the subacute phase compared with controls, significant increase was observed in temporal regions and decrease in occipital and frontal lobes. Differences tended to normalize at the late phase with only few of them remaining significant (predominately the frontal lobe, including the right middle and superior frontal gyri and left middle fronto-orbital gyrus). The direct comparison between PCS+ and PCS– patients showed that temporal regions presented increased values in PCS+ patients (left superior temporal gyrus and left temporal pole) at the subacute phase, whereas no differences were observed at late phase. In contrast the frontal regions showed the opposite pattern with no difference at the early phase and significant differences at the late phase. When comparing with control subjects, the thalamus had lower topological properties in both PCS+ and PCS– patients at the subacute phase that remained slightly different at the late phase in PCS– patients only (Figure 4). No significant difference was observed in edge centrality.


Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.

Messé A, Caplain S, Pélégrini-Issac M, Blancho S, Lévy R, Aghakhani N, Montreuil M, Benali H, Lehéricy S - PLoS ONE (2013)

Brain regions with significant group differences in topological graph properties (k, El, En and bc) between mTBI patients and controls at p<0.05 (uncorrected).The node size indicates the number of topological properties with significant group differences. The nodal regions are located according to their centroid stereotaxic coordinates. Nodal color code for the average size effect, hot (resp. cold) colors represent increased (resp. decreased) properties.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3675039&req=5

pone-0065470-g004: Brain regions with significant group differences in topological graph properties (k, El, En and bc) between mTBI patients and controls at p<0.05 (uncorrected).The node size indicates the number of topological properties with significant group differences. The nodal regions are located according to their centroid stereotaxic coordinates. Nodal color code for the average size effect, hot (resp. cold) colors represent increased (resp. decreased) properties.
Mentions: Patients presented more differences in topological properties than in connectivity measures. In PCS– patients compared with controls differences were mostly found at the late phase in the limbic system with an increase in properties (Figure 4). In PCS+ patients at the subacute phase compared with controls, significant increase was observed in temporal regions and decrease in occipital and frontal lobes. Differences tended to normalize at the late phase with only few of them remaining significant (predominately the frontal lobe, including the right middle and superior frontal gyri and left middle fronto-orbital gyrus). The direct comparison between PCS+ and PCS– patients showed that temporal regions presented increased values in PCS+ patients (left superior temporal gyrus and left temporal pole) at the subacute phase, whereas no differences were observed at late phase. In contrast the frontal regions showed the opposite pattern with no difference at the early phase and significant differences at the late phase. When comparing with control subjects, the thalamus had lower topological properties in both PCS+ and PCS– patients at the subacute phase that remained slightly different at the late phase in PCS– patients only (Figure 4). No significant difference was observed in edge centrality.

Bottom Line: Group-wise differences in functional brain networks were analyzed using graph theory measures.Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients.Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.

View Article: PubMed Central - PubMed

Affiliation: Inserm, UPMC Univ Paris 06, UMRS 678, Laboratoire d'Imagerie Fonctionnelle, Paris, France. Arnaud.Messe@imed.jussieu.fr

ABSTRACT
Post-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injury in patients with post-concussion syndrome using resting-state functional magnetic resonance imaging data. We investigated 17 injured patients with persistent post-concussion syndrome (under the DSM-IV criteria) at 6 months post-injury compared with 38 mild traumatic brain injury patients with no post-concussion syndrome and 34 healthy controls. All patients underwent magnetic resonance imaging examinations at the subacute (1-3 weeks) and late (6 months) phases after injury. Group-wise differences in functional brain networks were analyzed using graph theory measures. Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients. Mild traumatic brain injury patients with post-concussion syndrome had greater alterations than patients without post-concussion syndrome. In patients with post-concussion syndrome, changes specifically affected temporal and thalamic regions predominantly at the subacute stage and frontal regions at the late phase. Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.

Show MeSH
Related in: MedlinePlus