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Running interference? Exercise and PCB-induced changes in the gut microbiome.

Potera C - Environ. Health Perspect. (2013)

View Article: PubMed Central - PubMed

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However, mice that exercised daily before PCB dosing began showed fewer changes to the gut microbiome than sedentary mice... After a five-week exercise period all mice were dosed with a mixture of PCB138, PCB153, and PCB180 for two days... These PCB congeners and the amounts given reflect those found in high concentrations in contaminated fish from the Great Lakes, according to senior author Michal Toborek, Leonard M... In sedentary mice PCB exposure was associated with a nearly sixfold decrease in Proteobacteria, whereas mice that exercised did not experience a significant drop in Proteobacteria abundance... The physiological importance of the changes in gut bacteria remains to be determined... Other researchers have reported depletion of Firmicutes and increased levels of Proteobacteria in the guts of patients with inflammatory bowel disease and a relative abundance of Erysipelotrichaceae in patients with colorectal cancer, compared with healthy controls... Studies suggest that Bacteroidetes species are reduced and Firmicutes are elevated in obesity, and that the levels reciprocally reverse after weight loss... Other experiments will look at the influence of the gut microbiome on the chemical fate of PCBs... These biotransformations can either diminish or enhance the toxicity of substances such as PCBs. “It’s well known that diet may alter biological responses to environmental [toxicants], but the role of gut flora in toxification processes has rarely been evaluated,” says Larry W... Robertson, a University of Iowa professor of occupational and environmental health... Toborek’s results give new insights into the relationship between the gut microbiome and toxicity as well as the ways in which exercise alters the gut microbiome and toxicity... In addition to promoting diet and exercise for good health, Robertson says, perhaps we should include the role our gut flora play in wellness.

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In this study, the mice’s running activity was monitored via a direct data link to a computer running Clocklab™ Analysis software. Mice that exercised before PCB exposure showed fewer changes to the gut microbiome than sedentary mice.Gretchen Wolff/University of Miami Miller School of Medicine
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f1: In this study, the mice’s running activity was monitored via a direct data link to a computer running Clocklab™ Analysis software. Mice that exercised before PCB exposure showed fewer changes to the gut microbiome than sedentary mice.Gretchen Wolff/University of Miami Miller School of Medicine


Running interference? Exercise and PCB-induced changes in the gut microbiome.

Potera C - Environ. Health Perspect. (2013)

In this study, the mice’s running activity was monitored via a direct data link to a computer running Clocklab™ Analysis software. Mice that exercised before PCB exposure showed fewer changes to the gut microbiome than sedentary mice.Gretchen Wolff/University of Miami Miller School of Medicine
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672929&req=5

f1: In this study, the mice’s running activity was monitored via a direct data link to a computer running Clocklab™ Analysis software. Mice that exercised before PCB exposure showed fewer changes to the gut microbiome than sedentary mice.Gretchen Wolff/University of Miami Miller School of Medicine

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

However, mice that exercised daily before PCB dosing began showed fewer changes to the gut microbiome than sedentary mice... After a five-week exercise period all mice were dosed with a mixture of PCB138, PCB153, and PCB180 for two days... These PCB congeners and the amounts given reflect those found in high concentrations in contaminated fish from the Great Lakes, according to senior author Michal Toborek, Leonard M... In sedentary mice PCB exposure was associated with a nearly sixfold decrease in Proteobacteria, whereas mice that exercised did not experience a significant drop in Proteobacteria abundance... The physiological importance of the changes in gut bacteria remains to be determined... Other researchers have reported depletion of Firmicutes and increased levels of Proteobacteria in the guts of patients with inflammatory bowel disease and a relative abundance of Erysipelotrichaceae in patients with colorectal cancer, compared with healthy controls... Studies suggest that Bacteroidetes species are reduced and Firmicutes are elevated in obesity, and that the levels reciprocally reverse after weight loss... Other experiments will look at the influence of the gut microbiome on the chemical fate of PCBs... These biotransformations can either diminish or enhance the toxicity of substances such as PCBs. “It’s well known that diet may alter biological responses to environmental [toxicants], but the role of gut flora in toxification processes has rarely been evaluated,” says Larry W... Robertson, a University of Iowa professor of occupational and environmental health... Toborek’s results give new insights into the relationship between the gut microbiome and toxicity as well as the ways in which exercise alters the gut microbiome and toxicity... In addition to promoting diet and exercise for good health, Robertson says, perhaps we should include the role our gut flora play in wellness.

Show MeSH
Related in: MedlinePlus