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Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience.

Meaney PM, Kaufman PA, Muffly LS, Click M, Poplack SP, Wells WA, Schwartz GN, di Florio-Alexander RM, Tosteson TD, Li Z, Geimer SD, Fanning MW, Zhou T, Epstein NR, Paulsen KD - Breast Cancer Res. (2013)

Bottom Line: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically.Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004).In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Introduction: Microwave tomography recovers images of tissue dielectric properties, which appear to be specific for breast cancer, with low-cost technology that does not present an exposure risk, suggesting the modality may be a good candidate for monitoring neoadjuvant chemotherapy.

Methods: Eight patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer were imaged longitudinally five to eight times during the course of treatment. At the start of therapy, regions of interest (ROIs) were identified from contrast-enhanced magnetic resonance imaging studies. During subsequent microwave examinations, subjects were positioned with their breasts pendant in a coupling fluid and surrounded by an immersed antenna array. Microwave property values were extracted from the ROIs through an automated procedure and statistical analyses were performed to assess short term (30 days) and longer term (four to six months) dielectric property changes.

Results: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically. Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004). In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

Conclusions: These preliminary findings suggest that both early and late conductivity property changes correlate well with overall treatment response to neoadjuvant therapy in locally advanced breast cancer. This result is consistent with earlier clinical outcomes that lesion conductivity is specific to differentiating breast cancer from benign lesions and normal tissue.

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Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.
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Figure 7: Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.

Mentions: Figure 7 summarizes the ROI:background ratios for both the permittivity and conductivity images as a function of time. In this case, the permittivity ROI:background values remain relatively constant but then increase dramatically towards the end of treatment. The corresponding conductivity ratios are much more uneven with sharp increases at day 2 and day 28. The uneven behavior may be due in part to the fact that the tumor did appear to partially respond in some areas (for example, during the first 21 days) but then expanded towards the anterior portion of the breast. Nonetheless, the ROI:background values did not decrease appreciably at any extended duration during treatment and are consistent with the pathological determination of non-response.


Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience.

Meaney PM, Kaufman PA, Muffly LS, Click M, Poplack SP, Wells WA, Schwartz GN, di Florio-Alexander RM, Tosteson TD, Li Z, Geimer SD, Fanning MW, Zhou T, Epstein NR, Paulsen KD - Breast Cancer Res. (2013)

Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672734&req=5

Figure 7: Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.
Mentions: Figure 7 summarizes the ROI:background ratios for both the permittivity and conductivity images as a function of time. In this case, the permittivity ROI:background values remain relatively constant but then increase dramatically towards the end of treatment. The corresponding conductivity ratios are much more uneven with sharp increases at day 2 and day 28. The uneven behavior may be due in part to the fact that the tumor did appear to partially respond in some areas (for example, during the first 21 days) but then expanded towards the anterior portion of the breast. Nonetheless, the ROI:background values did not decrease appreciably at any extended duration during treatment and are consistent with the pathological determination of non-response.

Bottom Line: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically.Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004).In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Introduction: Microwave tomography recovers images of tissue dielectric properties, which appear to be specific for breast cancer, with low-cost technology that does not present an exposure risk, suggesting the modality may be a good candidate for monitoring neoadjuvant chemotherapy.

Methods: Eight patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer were imaged longitudinally five to eight times during the course of treatment. At the start of therapy, regions of interest (ROIs) were identified from contrast-enhanced magnetic resonance imaging studies. During subsequent microwave examinations, subjects were positioned with their breasts pendant in a coupling fluid and surrounded by an immersed antenna array. Microwave property values were extracted from the ROIs through an automated procedure and statistical analyses were performed to assess short term (30 days) and longer term (four to six months) dielectric property changes.

Results: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically. Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004). In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

Conclusions: These preliminary findings suggest that both early and late conductivity property changes correlate well with overall treatment response to neoadjuvant therapy in locally advanced breast cancer. This result is consistent with earlier clinical outcomes that lesion conductivity is specific to differentiating breast cancer from benign lesions and normal tissue.

Show MeSH
Related in: MedlinePlus