Limits...
Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience.

Meaney PM, Kaufman PA, Muffly LS, Click M, Poplack SP, Wells WA, Schwartz GN, di Florio-Alexander RM, Tosteson TD, Li Z, Geimer SD, Fanning MW, Zhou T, Epstein NR, Paulsen KD - Breast Cancer Res. (2013)

Bottom Line: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically.Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004).In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Introduction: Microwave tomography recovers images of tissue dielectric properties, which appear to be specific for breast cancer, with low-cost technology that does not present an exposure risk, suggesting the modality may be a good candidate for monitoring neoadjuvant chemotherapy.

Methods: Eight patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer were imaged longitudinally five to eight times during the course of treatment. At the start of therapy, regions of interest (ROIs) were identified from contrast-enhanced magnetic resonance imaging studies. During subsequent microwave examinations, subjects were positioned with their breasts pendant in a coupling fluid and surrounded by an immersed antenna array. Microwave property values were extracted from the ROIs through an automated procedure and statistical analyses were performed to assess short term (30 days) and longer term (four to six months) dielectric property changes.

Results: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically. Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004). In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

Conclusions: These preliminary findings suggest that both early and late conductivity property changes correlate well with overall treatment response to neoadjuvant therapy in locally advanced breast cancer. This result is consistent with earlier clinical outcomes that lesion conductivity is specific to differentiating breast cancer from benign lesions and normal tissue.

Show MeSH

Related in: MedlinePlus

Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3672734&req=5

Figure 4: Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.

Mentions: Figure 4 summarizes the 1,300 MHz ROI:background property ratios as a function of time for all MT examinations during treatment of this patient. The permittivity ratio decreased somewhat unevenly and had a total reduction of 38% from the start to end of treatment. The εr value did not drop below 89% of its initial level until the day 114 examination. The conductivity ratio exhibited a more dramatic and earlier reduction - 56% decrease after 23 days and 82% decrease after treatment completion, respectively, which is consistent with our previous clinical results that indicated the conductivity images are significantly more sensitive to the presence of tumor than their permittivity partners.


Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience.

Meaney PM, Kaufman PA, Muffly LS, Click M, Poplack SP, Wells WA, Schwartz GN, di Florio-Alexander RM, Tosteson TD, Li Z, Geimer SD, Fanning MW, Zhou T, Epstein NR, Paulsen KD - Breast Cancer Res. (2013)

Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672734&req=5

Figure 4: Summary of the permittivity and conductivity region of interest (ROI) analysis for the MT imaging sessions from the start of treatment until just prior to surgery. MT, microwave tomography.
Mentions: Figure 4 summarizes the 1,300 MHz ROI:background property ratios as a function of time for all MT examinations during treatment of this patient. The permittivity ratio decreased somewhat unevenly and had a total reduction of 38% from the start to end of treatment. The εr value did not drop below 89% of its initial level until the day 114 examination. The conductivity ratio exhibited a more dramatic and earlier reduction - 56% decrease after 23 days and 82% decrease after treatment completion, respectively, which is consistent with our previous clinical results that indicated the conductivity images are significantly more sensitive to the presence of tumor than their permittivity partners.

Bottom Line: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically.Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004).In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Introduction: Microwave tomography recovers images of tissue dielectric properties, which appear to be specific for breast cancer, with low-cost technology that does not present an exposure risk, suggesting the modality may be a good candidate for monitoring neoadjuvant chemotherapy.

Methods: Eight patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer were imaged longitudinally five to eight times during the course of treatment. At the start of therapy, regions of interest (ROIs) were identified from contrast-enhanced magnetic resonance imaging studies. During subsequent microwave examinations, subjects were positioned with their breasts pendant in a coupling fluid and surrounded by an immersed antenna array. Microwave property values were extracted from the ROIs through an automated procedure and statistical analyses were performed to assess short term (30 days) and longer term (four to six months) dielectric property changes.

Results: Two patient cases (one complete and one partial response) are presented in detail and demonstrate changes in microwave properties commensurate with the degree of treatment response observed pathologically. Normalized mean conductivity in ROIs from patients with complete pathological responses was significantly different from that of partial responders (P value = 0.004). In addition, the normalized conductivity measure also correlated well with complete pathological response at 30 days (P value = 0.002).

Conclusions: These preliminary findings suggest that both early and late conductivity property changes correlate well with overall treatment response to neoadjuvant therapy in locally advanced breast cancer. This result is consistent with earlier clinical outcomes that lesion conductivity is specific to differentiating breast cancer from benign lesions and normal tissue.

Show MeSH
Related in: MedlinePlus