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Fructose and lactose intolerance and malabsorption testing: the relationship with symptoms in functional gastrointestinal disorders.

Wilder-Smith CH, Materna A, Wermelinger C, Schuler J - Aliment. Pharmacol. Ther. (2013)

Bottom Line: The effectiveness of a targeted saccharide-reduced diet was assessed after 6-8 weeks.Non-GI symptoms occurred more commonly in patients with intolerances.Methane breath levels were not associated with constipation using several cut-off thresholds.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterology Group Practice, Brain-Gut Research Group, Bern, Switzerland. cws@braingut.com

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Related in: MedlinePlus

Percentages of patients with Functional Gastrointestinal Disorders (FGID) with fructose (n = 613) or lactose (n = 432) malabsorption, i.e. an increase of H2 > 20 ppm or CH4>10 ppm over baseline, with diarrhoea or constipation. *P < 0.05 constipation vs. diarrhoea for both fructose and lactose.
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fig03: Percentages of patients with Functional Gastrointestinal Disorders (FGID) with fructose (n = 613) or lactose (n = 432) malabsorption, i.e. an increase of H2 > 20 ppm or CH4>10 ppm over baseline, with diarrhoea or constipation. *P < 0.05 constipation vs. diarrhoea for both fructose and lactose.

Mentions: In patients with fructose or lactose malabsorption, as defined by any of the H2 or CH4 thresholds, diarrhoea was more common than constipation (all P < 0.05) (Figure 3). Conversely, patients with diarrhoea and constipation had a similar prevalence of malabsorption demonstrated by isolated elevation of H2 (14.5% and 11.3%) and CH4 (1.2% and 1.2%) concentrations following fructose and lactose ((7.7% and 6.5%) and (1.4% and 1.6%)) respectively. Furthermore, a majority (69%) of IBS-C patients did not have elevated CH4 levels after either sugar.


Fructose and lactose intolerance and malabsorption testing: the relationship with symptoms in functional gastrointestinal disorders.

Wilder-Smith CH, Materna A, Wermelinger C, Schuler J - Aliment. Pharmacol. Ther. (2013)

Percentages of patients with Functional Gastrointestinal Disorders (FGID) with fructose (n = 613) or lactose (n = 432) malabsorption, i.e. an increase of H2 > 20 ppm or CH4>10 ppm over baseline, with diarrhoea or constipation. *P < 0.05 constipation vs. diarrhoea for both fructose and lactose.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672687&req=5

fig03: Percentages of patients with Functional Gastrointestinal Disorders (FGID) with fructose (n = 613) or lactose (n = 432) malabsorption, i.e. an increase of H2 > 20 ppm or CH4>10 ppm over baseline, with diarrhoea or constipation. *P < 0.05 constipation vs. diarrhoea for both fructose and lactose.
Mentions: In patients with fructose or lactose malabsorption, as defined by any of the H2 or CH4 thresholds, diarrhoea was more common than constipation (all P < 0.05) (Figure 3). Conversely, patients with diarrhoea and constipation had a similar prevalence of malabsorption demonstrated by isolated elevation of H2 (14.5% and 11.3%) and CH4 (1.2% and 1.2%) concentrations following fructose and lactose ((7.7% and 6.5%) and (1.4% and 1.6%)) respectively. Furthermore, a majority (69%) of IBS-C patients did not have elevated CH4 levels after either sugar.

Bottom Line: The effectiveness of a targeted saccharide-reduced diet was assessed after 6-8 weeks.Non-GI symptoms occurred more commonly in patients with intolerances.Methane breath levels were not associated with constipation using several cut-off thresholds.

View Article: PubMed Central - PubMed

Affiliation: Gastroenterology Group Practice, Brain-Gut Research Group, Bern, Switzerland. cws@braingut.com

Show MeSH
Related in: MedlinePlus