Limits...
Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing.

Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, Schott BH - Front Hum Neurosci (2013)

Bottom Line: Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards.Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both).Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Behavioral Neurology and Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany.

ABSTRACT
Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards. This dual function of dopamine suggests that dopamine might be involved in the generation of active motivated behavior. The DRD2 TaqIA polymorphism of the dopamine D2 receptor gene (rs1800497) has previously been suggested to affect striatal function with carriers of the less common A1 allele exhibiting reduced striatal D2 receptor density and increased risk for addiction. Here we aimed to investigate the influences of DRD2 TaqIA genotype on the modulation of interference processing by reward and punishment. Forty-six young, healthy volunteers participated in a behavioral experiment, and 32 underwent functional magnetic resonance imaging (fMRI). Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both). Reaction times (RTs) were shorter in motivated flanker trials, irrespective of congruency. In the fMRI experiment motivation was associated with reduced prefrontal activation during incongruent vs. congruent flanker trials, possibly reflecting increased processing efficiency. DRD2 TaqIA genotype did not affect overall RTs, but interacted with motivation on the congruency-related RT differences, with A1 carriers showing smaller interference effects to reward alone and A2 homozygotes exhibiting a specific interference reduction during combined reward (REW) and punishment trials (PUN). In fMRI, anterior cingulate activity showed a similar pattern of genotype-related modulation. Additionally, A1 carriers showed increased anterior insula activation relative to A2 homozygotes. Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

No MeSH data available.


Related in: MedlinePlus

Interaction of genotype, congruency, and motivation. Complex genotype-dependent modulation of interference processing was observed in anterior cingulate cortex (ACC) and striatum. The three-way interaction of congruency × motivation × genotype is displayed, which was significant for the ACC at p < 0.05, small-volume FWE-corrected for ROI volumes. Activations are superimposed on the MNI template brain provided by MRIcron. Coordinates are in MNI space. Bar plots depict contrasts of parameter estimates at the peak coordinate separated by genotypes and motivation conditions. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition; INC, incongruent; CON, congruent.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3672681&req=5

Figure 6: Interaction of genotype, congruency, and motivation. Complex genotype-dependent modulation of interference processing was observed in anterior cingulate cortex (ACC) and striatum. The three-way interaction of congruency × motivation × genotype is displayed, which was significant for the ACC at p < 0.05, small-volume FWE-corrected for ROI volumes. Activations are superimposed on the MNI template brain provided by MRIcron. Coordinates are in MNI space. Bar plots depict contrasts of parameter estimates at the peak coordinate separated by genotypes and motivation conditions. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition; INC, incongruent; CON, congruent.

Mentions: In addition to the main effect of genotype in the anterior insula, we observed a three-way interaction (congruency × motivation × genotype) in the ACC [x, y, z = 9, 38, 28; F(3, 240) = 8.44; p = 0.006, FWE-corrected for ROI volume; see Figure 6, top]. Post-hoc two-sample T-tests over the contrasts of parameter estimates (incongruent vs. congruent) at the peak voxel in the right ACC revealed that A2 homozygotes showed higher activation in the trials with potential reward when compared to A1 carriers [ACC: t(30) = −2.87; p = 0.007] while A1 carriers as compared to A2 homozygotes exhibited increased activation of the right ACC in the combined reward and punishment condition [t(30) = 3.12; p = 0.004]. We also observed a trend for a three-way interaction in the right striatum [x, y, z = 21, −1, −2; F(3, 240) = 6.02; p = 0.050, FWE-corrected for ROI volume; see Figure 6, bottom], but this did not survive Bonferroni correction for multiple ROIs.


Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing.

Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, Schott BH - Front Hum Neurosci (2013)

Interaction of genotype, congruency, and motivation. Complex genotype-dependent modulation of interference processing was observed in anterior cingulate cortex (ACC) and striatum. The three-way interaction of congruency × motivation × genotype is displayed, which was significant for the ACC at p < 0.05, small-volume FWE-corrected for ROI volumes. Activations are superimposed on the MNI template brain provided by MRIcron. Coordinates are in MNI space. Bar plots depict contrasts of parameter estimates at the peak coordinate separated by genotypes and motivation conditions. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition; INC, incongruent; CON, congruent.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672681&req=5

Figure 6: Interaction of genotype, congruency, and motivation. Complex genotype-dependent modulation of interference processing was observed in anterior cingulate cortex (ACC) and striatum. The three-way interaction of congruency × motivation × genotype is displayed, which was significant for the ACC at p < 0.05, small-volume FWE-corrected for ROI volumes. Activations are superimposed on the MNI template brain provided by MRIcron. Coordinates are in MNI space. Bar plots depict contrasts of parameter estimates at the peak coordinate separated by genotypes and motivation conditions. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition; INC, incongruent; CON, congruent.
Mentions: In addition to the main effect of genotype in the anterior insula, we observed a three-way interaction (congruency × motivation × genotype) in the ACC [x, y, z = 9, 38, 28; F(3, 240) = 8.44; p = 0.006, FWE-corrected for ROI volume; see Figure 6, top]. Post-hoc two-sample T-tests over the contrasts of parameter estimates (incongruent vs. congruent) at the peak voxel in the right ACC revealed that A2 homozygotes showed higher activation in the trials with potential reward when compared to A1 carriers [ACC: t(30) = −2.87; p = 0.007] while A1 carriers as compared to A2 homozygotes exhibited increased activation of the right ACC in the combined reward and punishment condition [t(30) = 3.12; p = 0.004]. We also observed a trend for a three-way interaction in the right striatum [x, y, z = 21, −1, −2; F(3, 240) = 6.02; p = 0.050, FWE-corrected for ROI volume; see Figure 6, bottom], but this did not survive Bonferroni correction for multiple ROIs.

Bottom Line: Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards.Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both).Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Behavioral Neurology and Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany.

ABSTRACT
Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards. This dual function of dopamine suggests that dopamine might be involved in the generation of active motivated behavior. The DRD2 TaqIA polymorphism of the dopamine D2 receptor gene (rs1800497) has previously been suggested to affect striatal function with carriers of the less common A1 allele exhibiting reduced striatal D2 receptor density and increased risk for addiction. Here we aimed to investigate the influences of DRD2 TaqIA genotype on the modulation of interference processing by reward and punishment. Forty-six young, healthy volunteers participated in a behavioral experiment, and 32 underwent functional magnetic resonance imaging (fMRI). Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both). Reaction times (RTs) were shorter in motivated flanker trials, irrespective of congruency. In the fMRI experiment motivation was associated with reduced prefrontal activation during incongruent vs. congruent flanker trials, possibly reflecting increased processing efficiency. DRD2 TaqIA genotype did not affect overall RTs, but interacted with motivation on the congruency-related RT differences, with A1 carriers showing smaller interference effects to reward alone and A2 homozygotes exhibiting a specific interference reduction during combined reward (REW) and punishment trials (PUN). In fMRI, anterior cingulate activity showed a similar pattern of genotype-related modulation. Additionally, A1 carriers showed increased anterior insula activation relative to A2 homozygotes. Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

No MeSH data available.


Related in: MedlinePlus