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Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing.

Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, Schott BH - Front Hum Neurosci (2013)

Bottom Line: Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards.Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both).Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Behavioral Neurology and Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany.

ABSTRACT
Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards. This dual function of dopamine suggests that dopamine might be involved in the generation of active motivated behavior. The DRD2 TaqIA polymorphism of the dopamine D2 receptor gene (rs1800497) has previously been suggested to affect striatal function with carriers of the less common A1 allele exhibiting reduced striatal D2 receptor density and increased risk for addiction. Here we aimed to investigate the influences of DRD2 TaqIA genotype on the modulation of interference processing by reward and punishment. Forty-six young, healthy volunteers participated in a behavioral experiment, and 32 underwent functional magnetic resonance imaging (fMRI). Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both). Reaction times (RTs) were shorter in motivated flanker trials, irrespective of congruency. In the fMRI experiment motivation was associated with reduced prefrontal activation during incongruent vs. congruent flanker trials, possibly reflecting increased processing efficiency. DRD2 TaqIA genotype did not affect overall RTs, but interacted with motivation on the congruency-related RT differences, with A1 carriers showing smaller interference effects to reward alone and A2 homozygotes exhibiting a specific interference reduction during combined reward (REW) and punishment trials (PUN). In fMRI, anterior cingulate activity showed a similar pattern of genotype-related modulation. Additionally, A1 carriers showed increased anterior insula activation relative to A2 homozygotes. Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

No MeSH data available.


Related in: MedlinePlus

Neural correlates of congruency and motivation. (A) Effect of congruency. Incongruent trials elicited higher activity in dACC relative to congruent trials. Bar plots depict the corresponding parameter estimates of the parametric regressors at the ACC peak coordinate of the contrast incongruent vs. congruent trials are shown, separated by motivation conditions (± standard errors). (B) Neural correlates of motivational salience. Brain regions exhibiting motivation-related activation differences include the striatum, the anterior insula, and the ACC. All activation maps are superimposed on the MNI template brain provided by MRIcron. Contrasts were significant at p < 0.05, FWE-corrected. Coordinates are in MNI space. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition.
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Figure 3: Neural correlates of congruency and motivation. (A) Effect of congruency. Incongruent trials elicited higher activity in dACC relative to congruent trials. Bar plots depict the corresponding parameter estimates of the parametric regressors at the ACC peak coordinate of the contrast incongruent vs. congruent trials are shown, separated by motivation conditions (± standard errors). (B) Neural correlates of motivational salience. Brain regions exhibiting motivation-related activation differences include the striatum, the anterior insula, and the ACC. All activation maps are superimposed on the MNI template brain provided by MRIcron. Contrasts were significant at p < 0.05, FWE-corrected. Coordinates are in MNI space. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition.

Mentions: In line with previous studies (Ridderinkhof et al., 2004; Ullsperger and Von Cramon, 2004), a one-tailed T-test comparing BOLD responses of incongruent and congruent trials revealed increased activity in distributed regions of the DLPFC and in the dorsal anterior cingulate cortex (dACC; see Figure 3A, Table 4).


Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing.

Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, Schott BH - Front Hum Neurosci (2013)

Neural correlates of congruency and motivation. (A) Effect of congruency. Incongruent trials elicited higher activity in dACC relative to congruent trials. Bar plots depict the corresponding parameter estimates of the parametric regressors at the ACC peak coordinate of the contrast incongruent vs. congruent trials are shown, separated by motivation conditions (± standard errors). (B) Neural correlates of motivational salience. Brain regions exhibiting motivation-related activation differences include the striatum, the anterior insula, and the ACC. All activation maps are superimposed on the MNI template brain provided by MRIcron. Contrasts were significant at p < 0.05, FWE-corrected. Coordinates are in MNI space. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672681&req=5

Figure 3: Neural correlates of congruency and motivation. (A) Effect of congruency. Incongruent trials elicited higher activity in dACC relative to congruent trials. Bar plots depict the corresponding parameter estimates of the parametric regressors at the ACC peak coordinate of the contrast incongruent vs. congruent trials are shown, separated by motivation conditions (± standard errors). (B) Neural correlates of motivational salience. Brain regions exhibiting motivation-related activation differences include the striatum, the anterior insula, and the ACC. All activation maps are superimposed on the MNI template brain provided by MRIcron. Contrasts were significant at p < 0.05, FWE-corrected. Coordinates are in MNI space. NEU, neutral condition; REW, reward condition; PUN, punishment condition; COM, combined reward and punishment condition.
Mentions: In line with previous studies (Ridderinkhof et al., 2004; Ullsperger and Von Cramon, 2004), a one-tailed T-test comparing BOLD responses of incongruent and congruent trials revealed increased activity in distributed regions of the DLPFC and in the dorsal anterior cingulate cortex (dACC; see Figure 3A, Table 4).

Bottom Line: Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards.Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both).Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

View Article: PubMed Central - PubMed

Affiliation: Department of Behavioral Neurology and Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany.

ABSTRACT
Dopamine has been implicated in the fine-tuning of complex cognitive and motor function and also in the anticipation of future rewards. This dual function of dopamine suggests that dopamine might be involved in the generation of active motivated behavior. The DRD2 TaqIA polymorphism of the dopamine D2 receptor gene (rs1800497) has previously been suggested to affect striatal function with carriers of the less common A1 allele exhibiting reduced striatal D2 receptor density and increased risk for addiction. Here we aimed to investigate the influences of DRD2 TaqIA genotype on the modulation of interference processing by reward and punishment. Forty-six young, healthy volunteers participated in a behavioral experiment, and 32 underwent functional magnetic resonance imaging (fMRI). Participants performed a flanker task with a motivation manipulation (monetary reward, monetary loss, neither, or both). Reaction times (RTs) were shorter in motivated flanker trials, irrespective of congruency. In the fMRI experiment motivation was associated with reduced prefrontal activation during incongruent vs. congruent flanker trials, possibly reflecting increased processing efficiency. DRD2 TaqIA genotype did not affect overall RTs, but interacted with motivation on the congruency-related RT differences, with A1 carriers showing smaller interference effects to reward alone and A2 homozygotes exhibiting a specific interference reduction during combined reward (REW) and punishment trials (PUN). In fMRI, anterior cingulate activity showed a similar pattern of genotype-related modulation. Additionally, A1 carriers showed increased anterior insula activation relative to A2 homozygotes. Our results point to a role for genetic variations of the dopaminergic system in individual differences of cognition-motivation interaction.

No MeSH data available.


Related in: MedlinePlus