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Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons.

Fleischman DA, Yu L, Arfanakis K, Han SD, Barnes LL, Arvanitakis Z, Boyle PA, Bennett DA - Front Aging Neurosci (2013)

Bottom Line: Results showed that there was significant variability in the trajectories of cognitive change prior to imaging and that faster cognitive decline was associated with smaller hippocampal volumes.Domain-specific analyses suggested that this association was primarily driven by decline in working memory.The results emphasize the importance of closely examining cognitive change and its association with brain structure during the years in which older persons are considered cognitively healthy.

View Article: PubMed Central - PubMed

Affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center Chicago, IL, USA ; Department of Neurological Sciences, Rush University Medical Center Chicago, IL, USA ; Department of Behavioral Sciences, Rush University Medical Center Chicago, IL, USA.

ABSTRACT
Early identification of persons at risk for cognitive decline in aging is critical to optimizing treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD). To accomplish early identification, it is essential that trajectories of cognitive change be characterized and associations with established biomarkers of MCI and AD be examined during the phase in which older persons are considered cognitively healthy. Here we examined the association of rate of cognitive decline in the years leading up to structural magnetic resonance imaging with an established biomarker, hippocampal volume. The sample comprised 211 participants of the Rush Memory and Aging Project who had an average of 5.5 years of cognitive data prior to structural scanning. Results showed that there was significant variability in the trajectories of cognitive change prior to imaging and that faster cognitive decline was associated with smaller hippocampal volumes. Domain-specific analyses suggested that this association was primarily driven by decline in working memory. The results emphasize the importance of closely examining cognitive change and its association with brain structure during the years in which older persons are considered cognitively healthy.

No MeSH data available.


Related in: MedlinePlus

Mean difference in hippocampal volume between cognitive decliners and cognitive maintainers.
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Figure 3: Mean difference in hippocampal volume between cognitive decliners and cognitive maintainers.

Mentions: To illustrate the difference in hippocampal volumes between cognitively healthy persons with declining slopes (cognitive decliners, 57.8% of the sample) and cognitively healthy persons with non-negative slopes (cognitive maintainers, 42.2% of the sample), we present a prism-like plot showing the mean difference in hippocampal volume between the groups. Figure 3 shows that persons who declined in cognitive function prior to time of scan had on average smaller hippocampal volumes.


Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons.

Fleischman DA, Yu L, Arfanakis K, Han SD, Barnes LL, Arvanitakis Z, Boyle PA, Bennett DA - Front Aging Neurosci (2013)

Mean difference in hippocampal volume between cognitive decliners and cognitive maintainers.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672675&req=5

Figure 3: Mean difference in hippocampal volume between cognitive decliners and cognitive maintainers.
Mentions: To illustrate the difference in hippocampal volumes between cognitively healthy persons with declining slopes (cognitive decliners, 57.8% of the sample) and cognitively healthy persons with non-negative slopes (cognitive maintainers, 42.2% of the sample), we present a prism-like plot showing the mean difference in hippocampal volume between the groups. Figure 3 shows that persons who declined in cognitive function prior to time of scan had on average smaller hippocampal volumes.

Bottom Line: Results showed that there was significant variability in the trajectories of cognitive change prior to imaging and that faster cognitive decline was associated with smaller hippocampal volumes.Domain-specific analyses suggested that this association was primarily driven by decline in working memory.The results emphasize the importance of closely examining cognitive change and its association with brain structure during the years in which older persons are considered cognitively healthy.

View Article: PubMed Central - PubMed

Affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center Chicago, IL, USA ; Department of Neurological Sciences, Rush University Medical Center Chicago, IL, USA ; Department of Behavioral Sciences, Rush University Medical Center Chicago, IL, USA.

ABSTRACT
Early identification of persons at risk for cognitive decline in aging is critical to optimizing treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD). To accomplish early identification, it is essential that trajectories of cognitive change be characterized and associations with established biomarkers of MCI and AD be examined during the phase in which older persons are considered cognitively healthy. Here we examined the association of rate of cognitive decline in the years leading up to structural magnetic resonance imaging with an established biomarker, hippocampal volume. The sample comprised 211 participants of the Rush Memory and Aging Project who had an average of 5.5 years of cognitive data prior to structural scanning. Results showed that there was significant variability in the trajectories of cognitive change prior to imaging and that faster cognitive decline was associated with smaller hippocampal volumes. Domain-specific analyses suggested that this association was primarily driven by decline in working memory. The results emphasize the importance of closely examining cognitive change and its association with brain structure during the years in which older persons are considered cognitively healthy.

No MeSH data available.


Related in: MedlinePlus