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n-3 fatty acids, γ-linolenic acid, and antioxidants in sepsis.

Das UN - Crit Care (2013)

Bottom Line: The usefulness of n-3 fatty acids, γ-linolenic acid and antioxidants in the critically ill is controversial.I propose that adverse outcome in the critically ill is due to excess production of proinflammatory cytokines and eicosanoids from polyunsaturated fatty acids (PUFAs), while generation of anti-inflammatory products of PUFAs may lead to a favorable outcome.Hence, I suggest that measurement of plasma levels of various cytokines, free radicals, and proinflammatory and anti-inflammatory products of PUFAs and correlating them to the clinical picture may pave the way to identify prognostic markers and develop newer therapeutic strategies to prevent and manage critical illness.

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ABSTRACT
The usefulness of n-3 fatty acids, γ-linolenic acid and antioxidants in the critically ill is controversial. I propose that adverse outcome in the critically ill is due to excess production of proinflammatory cytokines and eicosanoids from polyunsaturated fatty acids (PUFAs), while generation of anti-inflammatory products of PUFAs may lead to a favorable outcome. Hence, I suggest that measurement of plasma levels of various cytokines, free radicals, and proinflammatory and anti-inflammatory products of PUFAs and correlating them to the clinical picture may pave the way to identify prognostic markers and develop newer therapeutic strategies to prevent and manage critical illness.

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Related in: MedlinePlus

Formation of resolvin E1 from eicosapentaenoic acid. COX, cyclooxygenase; EPE, eicosapentaenoic acid; LOX, lipoxygenase; LT, leukotriene; Rv, resolvin.
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Figure 3: Formation of resolvin E1 from eicosapentaenoic acid. COX, cyclooxygenase; EPE, eicosapentaenoic acid; LOX, lipoxygenase; LT, leukotriene; Rv, resolvin.


n-3 fatty acids, γ-linolenic acid, and antioxidants in sepsis.

Das UN - Crit Care (2013)

Formation of resolvin E1 from eicosapentaenoic acid. COX, cyclooxygenase; EPE, eicosapentaenoic acid; LOX, lipoxygenase; LT, leukotriene; Rv, resolvin.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3672630&req=5

Figure 3: Formation of resolvin E1 from eicosapentaenoic acid. COX, cyclooxygenase; EPE, eicosapentaenoic acid; LOX, lipoxygenase; LT, leukotriene; Rv, resolvin.
Bottom Line: The usefulness of n-3 fatty acids, γ-linolenic acid and antioxidants in the critically ill is controversial.I propose that adverse outcome in the critically ill is due to excess production of proinflammatory cytokines and eicosanoids from polyunsaturated fatty acids (PUFAs), while generation of anti-inflammatory products of PUFAs may lead to a favorable outcome.Hence, I suggest that measurement of plasma levels of various cytokines, free radicals, and proinflammatory and anti-inflammatory products of PUFAs and correlating them to the clinical picture may pave the way to identify prognostic markers and develop newer therapeutic strategies to prevent and manage critical illness.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
The usefulness of n-3 fatty acids, γ-linolenic acid and antioxidants in the critically ill is controversial. I propose that adverse outcome in the critically ill is due to excess production of proinflammatory cytokines and eicosanoids from polyunsaturated fatty acids (PUFAs), while generation of anti-inflammatory products of PUFAs may lead to a favorable outcome. Hence, I suggest that measurement of plasma levels of various cytokines, free radicals, and proinflammatory and anti-inflammatory products of PUFAs and correlating them to the clinical picture may pave the way to identify prognostic markers and develop newer therapeutic strategies to prevent and manage critical illness.

Show MeSH
Related in: MedlinePlus