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A case of locally advanced well-differentiated fetal adenocarcinoma of the lung treated with concurrent chemoradiation therapy.

Kyung C, Kim SY, Lim BJ, Cha JJ, Kim HJ, Ahn CM, Park H, Cho EN, Chang YS - Tuberc Respir Dis (Seoul) (2013)

Bottom Line: A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus.The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage.The followed-up image studies represent a partial response and the patient is currently under further observations.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Fetal adenocarcinoma is a rare adenocarcinoma subtype of pulmonary blastoma. A 48-year-old male patient is being referred to our hospital due to progressive dyspnea. A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus. After relieving the airway obstruction with stent insertion via bronchoscopy, a diagnosis of fetal adenocarcinoma is being confirmed through thoracoscopic biopsy. Due to the locally advanced state of the lung cancer, it seemed to be inoperable, and concurrent chemo-radiation therapy was being administered with docetaxel. The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage. Comparing to other contexts which describe fetal adenocarcinoma as lower grade malignancy with low-associated mortality, herein, we describe a case of locally-advanced fetal adenocarcinoma (T4N3M0). This is the first documented case being treated with concurrent chemoradiation therapy. The followed-up image studies represent a partial response and the patient is currently under further observations.

No MeSH data available.


Related in: MedlinePlus

The mass was composed of numerous glands showing endometrioid morphology, occasional squamoid morules, and relatively clear cytoplasm (H&E stain; A, ×100; B-D, ×400).
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Figure 4: The mass was composed of numerous glands showing endometrioid morphology, occasional squamoid morules, and relatively clear cytoplasm (H&E stain; A, ×100; B-D, ×400).

Mentions: Thoracoscopic biopsy of the mediastinal lymph node was performed. Gross examination revealed a single, 2 cm, white, well-defined mass that bled easily. Histopathologically, the mass was composed of numerous glands showing an endometrioid morphology, occasional squamoid morules (×400), and relatively clear cytoplasm (Figure 4). Based on these histopathological findings, we finalized the diagnosis as fetal adenocarcinoma.


A case of locally advanced well-differentiated fetal adenocarcinoma of the lung treated with concurrent chemoradiation therapy.

Kyung C, Kim SY, Lim BJ, Cha JJ, Kim HJ, Ahn CM, Park H, Cho EN, Chang YS - Tuberc Respir Dis (Seoul) (2013)

The mass was composed of numerous glands showing endometrioid morphology, occasional squamoid morules, and relatively clear cytoplasm (H&E stain; A, ×100; B-D, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672415&req=5

Figure 4: The mass was composed of numerous glands showing endometrioid morphology, occasional squamoid morules, and relatively clear cytoplasm (H&E stain; A, ×100; B-D, ×400).
Mentions: Thoracoscopic biopsy of the mediastinal lymph node was performed. Gross examination revealed a single, 2 cm, white, well-defined mass that bled easily. Histopathologically, the mass was composed of numerous glands showing an endometrioid morphology, occasional squamoid morules (×400), and relatively clear cytoplasm (Figure 4). Based on these histopathological findings, we finalized the diagnosis as fetal adenocarcinoma.

Bottom Line: A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus.The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage.The followed-up image studies represent a partial response and the patient is currently under further observations.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Fetal adenocarcinoma is a rare adenocarcinoma subtype of pulmonary blastoma. A 48-year-old male patient is being referred to our hospital due to progressive dyspnea. A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus. After relieving the airway obstruction with stent insertion via bronchoscopy, a diagnosis of fetal adenocarcinoma is being confirmed through thoracoscopic biopsy. Due to the locally advanced state of the lung cancer, it seemed to be inoperable, and concurrent chemo-radiation therapy was being administered with docetaxel. The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage. Comparing to other contexts which describe fetal adenocarcinoma as lower grade malignancy with low-associated mortality, herein, we describe a case of locally-advanced fetal adenocarcinoma (T4N3M0). This is the first documented case being treated with concurrent chemoradiation therapy. The followed-up image studies represent a partial response and the patient is currently under further observations.

No MeSH data available.


Related in: MedlinePlus