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A case of locally advanced well-differentiated fetal adenocarcinoma of the lung treated with concurrent chemoradiation therapy.

Kyung C, Kim SY, Lim BJ, Cha JJ, Kim HJ, Ahn CM, Park H, Cho EN, Chang YS - Tuberc Respir Dis (Seoul) (2013)

Bottom Line: A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus.The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage.The followed-up image studies represent a partial response and the patient is currently under further observations.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Fetal adenocarcinoma is a rare adenocarcinoma subtype of pulmonary blastoma. A 48-year-old male patient is being referred to our hospital due to progressive dyspnea. A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus. After relieving the airway obstruction with stent insertion via bronchoscopy, a diagnosis of fetal adenocarcinoma is being confirmed through thoracoscopic biopsy. Due to the locally advanced state of the lung cancer, it seemed to be inoperable, and concurrent chemo-radiation therapy was being administered with docetaxel. The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage. Comparing to other contexts which describe fetal adenocarcinoma as lower grade malignancy with low-associated mortality, herein, we describe a case of locally-advanced fetal adenocarcinoma (T4N3M0). This is the first documented case being treated with concurrent chemoradiation therapy. The followed-up image studies represent a partial response and the patient is currently under further observations.

No MeSH data available.


Related in: MedlinePlus

(A) Flexible bronchoscopy allowed for the placement of a stent from the carina to the left main bronchus, extending to the second left carina. (B) Three-month followed-up flexible bronchoscopy showed relief of the airway obstruction of both the right and left main bronchi, which improved the ease of passing the scope.
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Figure 3: (A) Flexible bronchoscopy allowed for the placement of a stent from the carina to the left main bronchus, extending to the second left carina. (B) Three-month followed-up flexible bronchoscopy showed relief of the airway obstruction of both the right and left main bronchi, which improved the ease of passing the scope.

Mentions: Chest X-ray (Figure 1A) showed a large mass in the right paratracheal area, causing tracheal deviation to the left with mild bronchopneumonia in the right lower lobe. The stent in the left main bronchus remained patent. Computed tomography (CT) revealed a 7.7×6.4 cm lobulated, heterogeneous enhancing mass abutting the trachea, carina, and both main bronchi, as well as multiple enlarged lymph nodes in the subclavian, right hilar, subcarinal, upper and lower paratracheal areas (Figure 2A). A metallic stent was placed in the left main bronchus and irregular narrowing of the right main bronchial wall was also observed. Flexible bronchoscopy (FBS) showed the placement of a stent from the carina to the left main bronchus, extending to the left second carina (Figure 3A). The left upper and lower bronchi appeared normal. A white fungating mass obstructing the right main bronchus and a pin-point opening due to a mass-like lesion were detected.


A case of locally advanced well-differentiated fetal adenocarcinoma of the lung treated with concurrent chemoradiation therapy.

Kyung C, Kim SY, Lim BJ, Cha JJ, Kim HJ, Ahn CM, Park H, Cho EN, Chang YS - Tuberc Respir Dis (Seoul) (2013)

(A) Flexible bronchoscopy allowed for the placement of a stent from the carina to the left main bronchus, extending to the second left carina. (B) Three-month followed-up flexible bronchoscopy showed relief of the airway obstruction of both the right and left main bronchi, which improved the ease of passing the scope.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672415&req=5

Figure 3: (A) Flexible bronchoscopy allowed for the placement of a stent from the carina to the left main bronchus, extending to the second left carina. (B) Three-month followed-up flexible bronchoscopy showed relief of the airway obstruction of both the right and left main bronchi, which improved the ease of passing the scope.
Mentions: Chest X-ray (Figure 1A) showed a large mass in the right paratracheal area, causing tracheal deviation to the left with mild bronchopneumonia in the right lower lobe. The stent in the left main bronchus remained patent. Computed tomography (CT) revealed a 7.7×6.4 cm lobulated, heterogeneous enhancing mass abutting the trachea, carina, and both main bronchi, as well as multiple enlarged lymph nodes in the subclavian, right hilar, subcarinal, upper and lower paratracheal areas (Figure 2A). A metallic stent was placed in the left main bronchus and irregular narrowing of the right main bronchial wall was also observed. Flexible bronchoscopy (FBS) showed the placement of a stent from the carina to the left main bronchus, extending to the left second carina (Figure 3A). The left upper and lower bronchi appeared normal. A white fungating mass obstructing the right main bronchus and a pin-point opening due to a mass-like lesion were detected.

Bottom Line: A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus.The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage.The followed-up image studies represent a partial response and the patient is currently under further observations.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Fetal adenocarcinoma is a rare adenocarcinoma subtype of pulmonary blastoma. A 48-year-old male patient is being referred to our hospital due to progressive dyspnea. A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus. After relieving the airway obstruction with stent insertion via bronchoscopy, a diagnosis of fetal adenocarcinoma is being confirmed through thoracoscopic biopsy. Due to the locally advanced state of the lung cancer, it seemed to be inoperable, and concurrent chemo-radiation therapy was being administered with docetaxel. The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage. Comparing to other contexts which describe fetal adenocarcinoma as lower grade malignancy with low-associated mortality, herein, we describe a case of locally-advanced fetal adenocarcinoma (T4N3M0). This is the first documented case being treated with concurrent chemoradiation therapy. The followed-up image studies represent a partial response and the patient is currently under further observations.

No MeSH data available.


Related in: MedlinePlus