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Primary malignant fibrous histiocytoma of the pleura.

Cho KH, Park C, Hwang KE, Hwang YR, Seol CH, Choi KH, Lee MK, Choi SH, Kim HR, Jeong ET - Tuberc Respir Dis (Seoul) (2013)

Bottom Line: Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm with uncertain origin that arises in both the soft tissues and the bone.The occurrence of primary malignant fibrous histiocytoma of the pleura is extremely rare.We report a case of a 65-year-old Korean man who is being diagnosed with primary malignant fibrous histiocytoma of the pleura.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.

ABSTRACT
Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm with uncertain origin that arises in both the soft tissues and the bone. The occurrence of primary malignant fibrous histiocytoma of the pleura is extremely rare. We report a case of a 65-year-old Korean man who is being diagnosed with primary malignant fibrous histiocytoma of the pleura.

No MeSH data available.


Related in: MedlinePlus

Histopathological examination of the biopsy specimen showed anaplastic cytomorphology, with marked nuclear pleomorphism and atypical mitoses (A, H&E stain, ×100). These tumor cells stained positively for vimentin (B, ×400) and CD68 (C, ×400).
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Figure 2: Histopathological examination of the biopsy specimen showed anaplastic cytomorphology, with marked nuclear pleomorphism and atypical mitoses (A, H&E stain, ×100). These tumor cells stained positively for vimentin (B, ×400) and CD68 (C, ×400).

Mentions: A 63-year-old man presented with dry cough of a 2-week duration. He had a history of pulmonary tuberculosis that had been treated with anti-tuberculosis medication 10 years ago. He was a farmer and former smoker, with 30 pack-years. Physical examination at the time of admission did not indicate any abnormality in the patient. Chest radiograph showed thickening in the right side of the apical pleura (Figure 1A). Chest computed tomography (CT) scans showed diffuse pleural thickening and a mass-like lesion with heterogenous enhancement (Figure 1B). Trans-thoracic needle biopsy was performed to rule out malignancy. Histopathological examination of the biopsy specimen showed anaplastic cytomorphology, with marked nuclear pleomorphism and atypical mitoses. Immunohistochemistry staining was performed. The panel of monoclonal antibodies consisted of CD68, vimentin, calretinin, cytokeratin 5/6 (CK 5/6), CK 7, thyroid transcription factor-1 (TTF-1), CD56, leukocyte common antigen (LCA), CD34, human melanoma black 45, and S-100. The tumor cells were positive for vimentin and CD68 (Figure 2). These cells were immunonegative for all other markers tested, ruling out carcinoma (cytokeratin), sarcomatous mesothelioma (calretinin), solitary fibrous tumor (CD34), and neurogenic sarcoma (S-100 protein).


Primary malignant fibrous histiocytoma of the pleura.

Cho KH, Park C, Hwang KE, Hwang YR, Seol CH, Choi KH, Lee MK, Choi SH, Kim HR, Jeong ET - Tuberc Respir Dis (Seoul) (2013)

Histopathological examination of the biopsy specimen showed anaplastic cytomorphology, with marked nuclear pleomorphism and atypical mitoses (A, H&E stain, ×100). These tumor cells stained positively for vimentin (B, ×400) and CD68 (C, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672414&req=5

Figure 2: Histopathological examination of the biopsy specimen showed anaplastic cytomorphology, with marked nuclear pleomorphism and atypical mitoses (A, H&E stain, ×100). These tumor cells stained positively for vimentin (B, ×400) and CD68 (C, ×400).
Mentions: A 63-year-old man presented with dry cough of a 2-week duration. He had a history of pulmonary tuberculosis that had been treated with anti-tuberculosis medication 10 years ago. He was a farmer and former smoker, with 30 pack-years. Physical examination at the time of admission did not indicate any abnormality in the patient. Chest radiograph showed thickening in the right side of the apical pleura (Figure 1A). Chest computed tomography (CT) scans showed diffuse pleural thickening and a mass-like lesion with heterogenous enhancement (Figure 1B). Trans-thoracic needle biopsy was performed to rule out malignancy. Histopathological examination of the biopsy specimen showed anaplastic cytomorphology, with marked nuclear pleomorphism and atypical mitoses. Immunohistochemistry staining was performed. The panel of monoclonal antibodies consisted of CD68, vimentin, calretinin, cytokeratin 5/6 (CK 5/6), CK 7, thyroid transcription factor-1 (TTF-1), CD56, leukocyte common antigen (LCA), CD34, human melanoma black 45, and S-100. The tumor cells were positive for vimentin and CD68 (Figure 2). These cells were immunonegative for all other markers tested, ruling out carcinoma (cytokeratin), sarcomatous mesothelioma (calretinin), solitary fibrous tumor (CD34), and neurogenic sarcoma (S-100 protein).

Bottom Line: Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm with uncertain origin that arises in both the soft tissues and the bone.The occurrence of primary malignant fibrous histiocytoma of the pleura is extremely rare.We report a case of a 65-year-old Korean man who is being diagnosed with primary malignant fibrous histiocytoma of the pleura.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.

ABSTRACT
Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm with uncertain origin that arises in both the soft tissues and the bone. The occurrence of primary malignant fibrous histiocytoma of the pleura is extremely rare. We report a case of a 65-year-old Korean man who is being diagnosed with primary malignant fibrous histiocytoma of the pleura.

No MeSH data available.


Related in: MedlinePlus