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View Article: PubMed Central

ABSTRACT

The fundamental role of actin in transcription

Cancer immunotherapy: mRNA as an off-the-shelf vaccine 

DNA methylation contributes to altered miRNA expression profiles in cervical cancer

miRNAs contribute to autophagy in cancer

No MeSH data available.


Figure 3. Epigenetics 2013; 8(2).
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Figure 3: Figure 3. Epigenetics 2013; 8(2).

Mentions: Cervical cancer is initiated by a persistent infection with high-risk (hr) types of the human papilloma virus (HPV) and represents the third most common cancer in women worldwide. The development of cervical squamous cell carcinoma (SCC) is characterized by well-defined precursor lesions, called cervical intraepithelial neoplasia (CIN), graded 1–3. Both chromosomal alterations and epigenetic changes are known to contribute to the necessary changes in gene expression during hrHPV-mediated transformation. Both mechanisms have recently been shown to be involved in the deregulation of microRNA (miR) expression in cervical cancer. Due to their ability to alter the expression of protein-coding oncogenes and tumor suppressor genes, miRs are now widely accepted as crucial players in cancer development. A previous study identified 32 miRs showing decreased expression in high-grade CIN and carcinomas not associated with a chromosomal loss, six of which were located within a CpG island. In a follow-up study, Dr Renske Steenbergen and colleagues investigated to what extent these miRs (hsa-miR-149, -203, -210, -375, -572 and -638) are subject to DNA methylation-mediated transcriptional repression in cervical carcinogenesis. The authors found evidence for methylation-mediated transcriptional repression of hsa-miR-149, -203 and -375 in cervical cancer. Methylation of the latter two was already apparent in precancerous lesions and represent functionally relevant events in HPV-mediated transformation. Increased hsa-miR-203 methylation was detectable in scrapes of women with high-grade CIN, indicating that methylated miRs may provide putative markers to assess the presence of (pre)cancerous lesions.1Figure 3.


Landes Highlights
Figure 3. Epigenetics 2013; 8(2).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672273&req=5

Figure 3: Figure 3. Epigenetics 2013; 8(2).
Mentions: Cervical cancer is initiated by a persistent infection with high-risk (hr) types of the human papilloma virus (HPV) and represents the third most common cancer in women worldwide. The development of cervical squamous cell carcinoma (SCC) is characterized by well-defined precursor lesions, called cervical intraepithelial neoplasia (CIN), graded 1–3. Both chromosomal alterations and epigenetic changes are known to contribute to the necessary changes in gene expression during hrHPV-mediated transformation. Both mechanisms have recently been shown to be involved in the deregulation of microRNA (miR) expression in cervical cancer. Due to their ability to alter the expression of protein-coding oncogenes and tumor suppressor genes, miRs are now widely accepted as crucial players in cancer development. A previous study identified 32 miRs showing decreased expression in high-grade CIN and carcinomas not associated with a chromosomal loss, six of which were located within a CpG island. In a follow-up study, Dr Renske Steenbergen and colleagues investigated to what extent these miRs (hsa-miR-149, -203, -210, -375, -572 and -638) are subject to DNA methylation-mediated transcriptional repression in cervical carcinogenesis. The authors found evidence for methylation-mediated transcriptional repression of hsa-miR-149, -203 and -375 in cervical cancer. Methylation of the latter two was already apparent in precancerous lesions and represent functionally relevant events in HPV-mediated transformation. Increased hsa-miR-203 methylation was detectable in scrapes of women with high-grade CIN, indicating that methylated miRs may provide putative markers to assess the presence of (pre)cancerous lesions.1Figure 3.

View Article: PubMed Central

ABSTRACT

The fundamental role of actin in transcription

Cancer immunotherapy: mRNA as an off-the-shelf vaccine 

DNA methylation contributes to altered miRNA expression profiles in cervical cancer

miRNAs contribute to autophagy in cancer

No MeSH data available.