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View Article: PubMed Central

ABSTRACT

The fundamental role of actin in transcription

Cancer immunotherapy: mRNA as an off-the-shelf vaccine 

DNA methylation contributes to altered miRNA expression profiles in cervical cancer

miRNAs contribute to autophagy in cancer

No MeSH data available.


Figure 1. Nucleus 2013; 4(1).
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Figure 1: Figure 1. Nucleus 2013; 4(1).

Mentions: Nuclear actin participates in chromatin remodeling and histone modifications. Moreover, it is involved in different phases of gene transcription by all three eukaryotic RNA polymerases. Actin is co-transcriptionally assembled into nascent ribonucleoproteins (RNPs), it is potentially involved in RNA processing and it is a component of ribosomes. In addition, nuclear actin interacts with certain transcription factors and determines their subcellular localization. Nuclear actin performs its multitask activities through tight interactions with different sets of proteins. This high degree of promiscuity in the spectrum of protein-to-protein interactions correlates well with the conformational plasticity of actin and the ability to undergo regulated changes in its polymerization states. A recent review by Dr Piergiorgio Percipalle discusses the fundamental role of actin in transcription. By focusing on the multiple tasks performed by actin and actin-binding proteins, possible models of how actin dynamics controls the different phases of the RNA polymerase II transcription cycle are being identified.1Figure 1.


Landes Highlights
Figure 1. Nucleus 2013; 4(1).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672273&req=5

Figure 1: Figure 1. Nucleus 2013; 4(1).
Mentions: Nuclear actin participates in chromatin remodeling and histone modifications. Moreover, it is involved in different phases of gene transcription by all three eukaryotic RNA polymerases. Actin is co-transcriptionally assembled into nascent ribonucleoproteins (RNPs), it is potentially involved in RNA processing and it is a component of ribosomes. In addition, nuclear actin interacts with certain transcription factors and determines their subcellular localization. Nuclear actin performs its multitask activities through tight interactions with different sets of proteins. This high degree of promiscuity in the spectrum of protein-to-protein interactions correlates well with the conformational plasticity of actin and the ability to undergo regulated changes in its polymerization states. A recent review by Dr Piergiorgio Percipalle discusses the fundamental role of actin in transcription. By focusing on the multiple tasks performed by actin and actin-binding proteins, possible models of how actin dynamics controls the different phases of the RNA polymerase II transcription cycle are being identified.1Figure 1.

View Article: PubMed Central

ABSTRACT

The fundamental role of actin in transcription

Cancer immunotherapy: mRNA as an off-the-shelf vaccine 

DNA methylation contributes to altered miRNA expression profiles in cervical cancer

miRNAs contribute to autophagy in cancer

No MeSH data available.